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The map label for this gene is hisC [H]

Identifier: 157963466

GI number: 157963466

Start: 4445229

End: 4446464

Strand: Reverse

Name: hisC [H]

Synonym: Spea_3654

Alternate gene names: 157963466

Gene position: 4446464-4445229 (Counterclockwise)

Preceding gene: 157963467

Following gene: 157963465

Centisome position: 85.93

GC content: 47.9

Gene sequence:

>1236_bases
ATGCAGTCAAATCTAATTGAACAAGAGTTAGTTAAACAAGAGTTAGTCAAACAAGAGCTAAATAAATCCGGGCTAAATAA
ACCAAAGCTGAATAAAATTAGCCGTCGTCAATTTCTCTATGCTGGCGCAGCTGTATCGAGCTTAGCCACCTTAGGTTGTA
GTTCGAGCTCTGTCTCTACAGCTGCTAGTTCGACAACAGCGACCGGGATGAGTGCGGATGAAGCGGTCCCGCTCAACTTT
AATGAAAATCCACTTGGTCTGGCACCTAAAGCGCAACAAGCCGTGCTTGATGCTCTACCTAATGCATGGCGCTATCCAGA
TGCTGCGCGCAGTCAGTTGATGGCAGCTATTGCAGAGAGTATCTCCGTAGCAGAATCGCAACTCATCTATGGAAATGGCT
CGTCAGAAGTATTGAAAATGGCACTGGATGCATTAGCGCAGACCAACAGTCAGCTAGTGATGCCAGACCCAAGCTATGGA
GTGGTCATCGATTATGCCATGGCGCGTGGGATCCCAGTTCTTAAGGTGAAACTCGACGGTCAGTGGCAAACCGATCTCGC
CAAAATGAAAGCGAAAGTGGCTGCACATAGTGGTCCGTCAATTGTGTATTTATGCAACCCTAATAACCCGACGGGTTTGT
TATTGCCGCAAAGTGAATTGAATCAATGGTTAGATCAGGCATCGAGTCAGCTGAGTTTTATCGTCGATGAGGCTTATGTG
GAATATGTCGCGCAAGCTGGGTTTGCATCGGCGGTTGAGCGGATTAAACAAGGCCAGCAGCATATCGTGGTCTGCAGAAC
CTTTTCAAAGATCTATGCCTTAGCAGGCTTACGTGTCGGTTACGGTGTCGCTCATGCTGATTTAATCAAACAAATGCAGG
CACAGGCCAGTATCGACAATGCCAACCTAATCGGTTGTGTTGCCGCTAAGGCCAGCCTTGAGAGCCCACAATGGTTAAGC
CTAAGTCTGCAATCCAATAACCAAGCTAAGGCACTGGTGTATCAGCAGTTAGCTAAACTCGGTTTAGACTATCTGCCGAG
CGAAACTAACTTTATCTTCCACAAGGTGAATGGTGACAGTGAGCTGTATATGCAGCGCATGGCAAAGGCGGGTATTTTAG
TCGGGCGTCCATTTAACCATGGTGAGGGATGGAACCGTCTGTCAATCGGCACACCAGCGCAGATGCAATACTTCAGCAAG
GCTTTAGCAAAGTTTCGCGAACTCGGCTGGGTGTAG

Upstream 100 bases:

>100_bases
TTTGTGATCTTGATTGCAAATCCCTCTCGCTTAACTAGCGGGAATGTTAGTTTCATATAATTATCTGTCGTAGGTAATAA
TTCAATAATAATAAATAAAT

Downstream 100 bases:

>100_bases
CTAAGAATAGTTTTTGAACCATTCCGCTCGCCTGTATTAAGTATTGCAATACTTAATACAGGCAGTGTGAGCTCGATAAA
AGCTACTTGTTACCTTAAAA

Product: class I/II aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MQSNLIEQELVKQELVKQELNKSGLNKPKLNKISRRQFLYAGAAVSSLATLGCSSSSVSTAASSTTATGMSADEAVPLNF
NENPLGLAPKAQQAVLDALPNAWRYPDAARSQLMAAIAESISVAESQLIYGNGSSEVLKMALDALAQTNSQLVMPDPSYG
VVIDYAMARGIPVLKVKLDGQWQTDLAKMKAKVAAHSGPSIVYLCNPNNPTGLLLPQSELNQWLDQASSQLSFIVDEAYV
EYVAQAGFASAVERIKQGQQHIVVCRTFSKIYALAGLRVGYGVAHADLIKQMQAQASIDNANLIGCVAAKASLESPQWLS
LSLQSNNQAKALVYQQLAKLGLDYLPSETNFIFHKVNGDSELYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFSK
ALAKFRELGWV

Sequences:

>Translated_411_residues
MQSNLIEQELVKQELVKQELNKSGLNKPKLNKISRRQFLYAGAAVSSLATLGCSSSSVSTAASSTTATGMSADEAVPLNF
NENPLGLAPKAQQAVLDALPNAWRYPDAARSQLMAAIAESISVAESQLIYGNGSSEVLKMALDALAQTNSQLVMPDPSYG
VVIDYAMARGIPVLKVKLDGQWQTDLAKMKAKVAAHSGPSIVYLCNPNNPTGLLLPQSELNQWLDQASSQLSFIVDEAYV
EYVAQAGFASAVERIKQGQQHIVVCRTFSKIYALAGLRVGYGVAHADLIKQMQAQASIDNANLIGCVAAKASLESPQWLS
LSLQSNNQAKALVYQQLAKLGLDYLPSETNFIFHKVNGDSELYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFSK
ALAKFRELGWV
>Mature_411_residues
MQSNLIEQELVKQELVKQELNKSGLNKPKLNKISRRQFLYAGAAVSSLATLGCSSSSVSTAASSTTATGMSADEAVPLNF
NENPLGLAPKAQQAVLDALPNAWRYPDAARSQLMAAIAESISVAESQLIYGNGSSEVLKMALDALAQTNSQLVMPDPSYG
VVIDYAMARGIPVLKVKLDGQWQTDLAKMKAKVAAHSGPSIVYLCNPNNPTGLLLPQSELNQWLDQASSQLSFIVDEAYV
EYVAQAGFASAVERIKQGQQHIVVCRTFSKIYALAGLRVGYGVAHADLIKQMQAQASIDNANLIGCVAAKASLESPQWLS
LSLQSNNQAKALVYQQLAKLGLDYLPSETNFIFHKVNGDSELYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFSK
ALAKFRELGWV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=370, Percent_Identity=25.1351351351351, Blast_Score=101, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6322075, Length=372, Percent_Identity=25.2688172043011, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 44455; Mature: 44455

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSNLIEQELVKQELVKQELNKSGLNKPKLNKISRRQFLYAGAAVSSLATLGCSSSSVST
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AASSTTATGMSADEAVPLNFNENPLGLAPKAQQAVLDALPNAWRYPDAARSQLMAAIAES
HCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ISVAESQLIYGNGSSEVLKMALDALAQTNSQLVMPDPSYGVVIDYAMARGIPVLKVKLDG
HHHHHCEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEHHHCCCEEEEEEECC
QWQTDLAKMKAKVAAHSGPSIVYLCNPNNPTGLLLPQSELNQWLDQASSQLSFIVDEAYV
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
EYVAQAGFASAVERIKQGQQHIVVCRTFSKIYALAGLRVGYGVAHADLIKQMQAQASIDN
HHHHHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
ANLIGCVAAKASLESPQWLSLSLQSNNQAKALVYQQLAKLGLDYLPSETNFIFHKVNGDS
CCEEEEEEHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCH
ELYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFSKALAKFRELGWV
HHHHHHHHHCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSNLIEQELVKQELVKQELNKSGLNKPKLNKISRRQFLYAGAAVSSLATLGCSSSSVST
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AASSTTATGMSADEAVPLNFNENPLGLAPKAQQAVLDALPNAWRYPDAARSQLMAAIAES
HCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ISVAESQLIYGNGSSEVLKMALDALAQTNSQLVMPDPSYGVVIDYAMARGIPVLKVKLDG
HHHHHCEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEHHHCCCEEEEEEECC
QWQTDLAKMKAKVAAHSGPSIVYLCNPNNPTGLLLPQSELNQWLDQASSQLSFIVDEAYV
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
EYVAQAGFASAVERIKQGQQHIVVCRTFSKIYALAGLRVGYGVAHADLIKQMQAQASIDN
HHHHHCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
ANLIGCVAAKASLESPQWLSLSLQSNNQAKALVYQQLAKLGLDYLPSETNFIFHKVNGDS
CCEEEEEEHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCH
ELYMQRMAKAGILVGRPFNHGEGWNRLSIGTPAQMQYFSKALAKFRELGWV
HHHHHHHHHCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA