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The map label for this gene is ppiB [H]

Identifier: 157963459

GI number: 157963459

Start: 4434861

End: 4435352

Strand: Reverse

Name: ppiB [H]

Synonym: Spea_3647

Alternate gene names: 157963459

Gene position: 4435352-4434861 (Counterclockwise)

Preceding gene: 157963461

Following gene: 157963456

Centisome position: 85.71

GC content: 45.53

Gene sequence:

>492_bases
ATGATTATTTTTACTACCAATTTAGGTGATATCGAGATTGAACTCGATCTGGAAAAGGCGCCAGTTAGCGCTAAGAACTT
TATCAAGTACTGCCAAGATGGCTTTTTTGAGGGCACGATTTTTCATCGCGTCATAAAAGGTTTTATGATCCAAGGTGGCG
GTTTTACTGCTGAGATGGAAGAGAAGCCGACTCGAGCGGCTATCGTTAACGAAGCTAATCGAGGCCTTAAGAATGTGCGT
GGCAGTATCGCCATGGCGCGCACCGATGCGCCGCATTCTGCTACCGGGCAATTTTTTATCAACTTAGCCGACAATAACTT
TTTAGATCATACCGCAACGACCAATGCGGGCTGGGGTTATGCGGTATTTGGTCAAGTCACTAAAGGTATGGATGTGGTCA
CTAAGATTGGCCGCGCGAAAACGACCTCTAAAGGCGACCATGATGATGTACCAAGAGAAACTATCATCATCGAAAAAGTC
ACCATCTGTTAG

Upstream 100 bases:

>100_bases
TCTAAGAAACTAGCGGGTGAGCTAACAATATATTTTCCTCTTAACTAAGAGTAAAATGTTGCCTTGGCCGCATTAAGCGC
ATGATGAGAGTGTGAGTACT

Downstream 100 bases:

>100_bases
TCGATAGAGTGGCTTATCTTAGATATTTAAAAAGCGCTTTAGGCGCTTTTTTAGTATCTATTGATAATGATTTTAGGGCT
TCGGGCGATTTAATGCTTTA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEMEEKPTRAAIVNEANRGLKNVR
GSIAMARTDAPHSATGQFFINLADNNFLDHTATTNAGWGYAVFGQVTKGMDVVTKIGRAKTTSKGDHDDVPRETIIIEKV
TIC

Sequences:

>Translated_163_residues
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEMEEKPTRAAIVNEANRGLKNVR
GSIAMARTDAPHSATGQFFINLADNNFLDHTATTNAGWGYAVFGQVTKGMDVVTKIGRAKTTSKGDHDDVPRETIIIEKV
TIC
>Mature_163_residues
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEMEEKPTRAAIVNEANRGLKNVR
GSIAMARTDAPHSATGQFFINLADNNFLDHTATTNAGWGYAVFGQVTKGMDVVTKIGRAKTTSKGDHDDVPRETIIIEKV
TIC

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=33.5365853658537, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI22547212, Length=160, Percent_Identity=33.125, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7657473, Length=160, Percent_Identity=33.125, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI19557636, Length=164, Percent_Identity=31.0975609756098, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=31.7647058823529, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI7706339, Length=145, Percent_Identity=31.7241379310345, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=35.6589147286822, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5174637, Length=155, Percent_Identity=32.258064516129, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310110104, Length=134, Percent_Identity=33.5820895522388, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=58.0246913580247, Blast_Score=197, Evalue=3e-52,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=54.4871794871795, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17539496, Length=176, Percent_Identity=32.9545454545455, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=28.7425149700599, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.2465753424658, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.2465753424658, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=133, Percent_Identity=33.0827067669173, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=30.6748466257669, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=159, Percent_Identity=32.7044025157233, Blast_Score=64, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=30.0613496932515, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19922376, Length=162, Percent_Identity=30.8641975308642, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922912, Length=153, Percent_Identity=32.0261437908497, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24652460, Length=146, Percent_Identity=28.0821917808219, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17860; Mature: 17860

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEME
CEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCEECCC
EKPTRAAIVNEANRGLKNVRGSIAMARTDAPHSATGQFFINLADNNFLDHTATTNAGWGY
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCEECCCCCCCCCCCE
AVFGQVTKGMDVVTKIGRAKTTSKGDHDDVPRETIIIEKVTIC
EEEHHHHCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEME
CEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCEECCC
EKPTRAAIVNEANRGLKNVRGSIAMARTDAPHSATGQFFINLADNNFLDHTATTNAGWGY
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCEECCCCCCCCCCCE
AVFGQVTKGMDVVTKIGRAKTTSKGDHDDVPRETIIIEKVTIC
EEEHHHHCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]