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The map label for this gene is parC [H]

Identifier: 157963370

GI number: 157963370

Start: 4342294

End: 4344561

Strand: Reverse

Name: parC [H]

Synonym: Spea_3556

Alternate gene names: 157963370

Gene position: 4344561-4342294 (Counterclockwise)

Preceding gene: 157963371

Following gene: 157963367

Centisome position: 83.96

GC content: 47.97

Gene sequence:

>2268_bases
ATGAGTGATGCGATAGATTTAAGCCTTGATGGCGTCGAGCAAATGCCTCTACGCCGCTTCACGGAAGAGGCATATCTGAA
CTATTCCATGTATGTCATCATGGATCGTGCGTTGCCACATATTGGCGATGGACTCAAGCCAGTTCAAAGACGTATTGTCT
ATGCCATGAGTGAGCTAGGCTTATCGGCTCAATCTAAACATAAGAAATCAGCGCGTACCGTCGGTGACGTGTTAGGTAAA
TATCACCCTCACGGTGATAGTGCCTGTTATGAAGCCATGGTATTGATGGCGCAGCCATTCTCGTATCGCTATCCACTGGT
TGATGGTCAAGGTAACTGGGGTGCTCCCGACGATCCTAAGTCCTTTGCTGCCATGCGTTACACCGAAGCTAGACTGTCTA
AGTTCTCGGAAGTACTACTTAGCGAGCTAGGTCAAGGTACAGTGGATTGGGGCGTTAACTTCGACGGCACCATGAAAGAG
CCGTTAGTGCTGCCTGCACGTTTGCCGCACATTTTACTCAATGGTATCACTGGCATCGCGGTGGGTATGGCAACAGATGT
ACCCCCACATAATGTTAAAGAGCTGGTGGGCGCCTGTGTTGAGTTACTGGATAACCCTAAAGCCGATTTAGCACGCCTGA
TGGAGTTTGTGCCTGGGCCAGATTATCCAACCGAAGCAGAGATTATTACGCCAGCGGCTGATATCACTAAAATCTACCAG
ACGGGTCGTGGTTCGATTAAGGCTCGTGCGGTTTATACCGTAGAAAATGGCGAAGTCGTGATTACTGCGCTGCCGCATCA
AGCCAGTAGCGGTAAGATTTTAGAGCAGATAGCCAGCCAGATGCAGGCAAAGAAGTTGCCTATGGTGACGGATCTGCGTG
ATGAATCCGATCACGAAAGCCCGGTTCGCATGGTGATTGTACCTCGCTCTAATCGCGTCGACTGTGAGCAGATGATGGCG
CATCTATTTGCGACAACAGATTTACAGAAAAGCTATCGAGTTAACTTAAACGTACTTGGGCTAAACGGTCGGCCGCAAGT
CAAAGGCCTACTAGAGTTATTAACTGAATGGCTCACGTTCAGAATGACTACGGTTAAGCGCCGTATAGAGTATCGATTAG
ACAAGATTTTATCGAGACTGCATATTCTAGATGCCTTGATGATTGCATTTTTGAATATCGATGAAGTGATTGAGATCATT
CGTTATAACGATGATCCCAAGGCTGAATTGATCTCACGCTTCAATCTGTCAGACAAGCAAGCCGATGCGATTCTTGATTT
AAAACTACGCCACTTAGCCAAGCTTGAAGAATTTAAGATCAAGGCTGAGCAGAGCGAGCTTGAAGCTGAGCGTGATAAGT
TACAACTATTGCTAAGTTCTGAGCGCCGTATGAAGACGCTGATCAAGAAAGAGCTTATCAAAGACAGTGAAGATTATGGT
GACGAGCGTCGTTCACCACTAGTTGAGCGTACAGAGTCTAGAGCGTTAACTGAGCAAGAGTTAGTGCCTGTTGAATCTGT
TACTGTCGTTTTATCAGAGAAAGGCTGGGTGCGTTGCGCTAAAGGCCATGAGGTTGATGGAAAGAGTCTGTCATATAAGG
CGGGCGATGGCTTCTTACGCTCCGCTCAAGGGCGTAGCAATCAACCGAGCGTGTTTATTGATACCTCGGGTCGAGCATTT
GCCACCGAAACCCATACCTTACCGTCTGCTCGTTCTCAAGGGGAACCAATTACCACTCGCTTCAATCTAGCTTCTGGAGC
GACCATGGAGCACCTACTGCTGTCTGATGAGGAGCAATGCTACCTACTCGCATCTGATGCAGGTTACGGCTTCATCTGTG
CTAATAAAGATATGGTATCGCGTAATAAGGCGGGTAAGGCACTTTTGAGCTTACCTGCTAATGCTAAGGTGTTGTTCCCG
CAGAGAGTCGATAAGTCTAAAGCTCAATCGATTCTAGCTATCACTAATGAAGGTCGAATGCTGCTGTTTTCTCTCGATGC
GCTGCCGCAGCTATCGAAGGGCAAAGGTAATAAGATTATCGGTATTCCAGGTGAACGAGCTAAGAATCGTGAAGAGTTGT
TATTGCACCTGAATGTTATCCCTGAAGACACTTCGGTAACCCTGTGGGCGGGTAAGCGCAAGCTAACCTTGAAGCCGAGT
GATCTTGAGCATTATCGAGGTGAGCGTGGCCGCCGTGGTGCCAAGTTACCGCGTGGTCTGCAACGTGTAGACAGTGTAGA
GCTAGGCGATGGTGAGCCTGTTCTCTAA

Upstream 100 bases:

>100_bases
CACCCGATGGTGCTATGTATATTTCTGATGATCTAAAGGGCAACGTCTACCGTTTGTTTTATAAAGAATCAGCAAAAAAT
CAGTCACAGGATAATGATTA

Downstream 100 bases:

>100_bases
GCTCTTACGAGGTTAAGTTACAACAAGACTAAGTCCATATAAGAGTAAGTAAAACAAAAAATGCAGCCAAGTGGCTGCAT
TTTTTTAGATGTAATTCGGG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKE
PLVLPARLPHILLNGITGIAVGMATDVPPHNVKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
TGRGSIKARAVYTVENGEVVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHESPVRMVIVPRSNRVDCEQMMA
HLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTFRMTTVKRRIEYRLDKILSRLHILDALMIAFLNIDEVIEII
RYNDDPKAELISRFNLSDKQADAILDLKLRHLAKLEEFKIKAEQSELEAERDKLQLLLSSERRMKTLIKKELIKDSEDYG
DERRSPLVERTESRALTEQELVPVESVTVVLSEKGWVRCAKGHEVDGKSLSYKAGDGFLRSAQGRSNQPSVFIDTSGRAF
ATETHTLPSARSQGEPITTRFNLASGATMEHLLLSDEEQCYLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLFP
QRVDKSKAQSILAITNEGRMLLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTSVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL

Sequences:

>Translated_755_residues
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKE
PLVLPARLPHILLNGITGIAVGMATDVPPHNVKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
TGRGSIKARAVYTVENGEVVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHESPVRMVIVPRSNRVDCEQMMA
HLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTFRMTTVKRRIEYRLDKILSRLHILDALMIAFLNIDEVIEII
RYNDDPKAELISRFNLSDKQADAILDLKLRHLAKLEEFKIKAEQSELEAERDKLQLLLSSERRMKTLIKKELIKDSEDYG
DERRSPLVERTESRALTEQELVPVESVTVVLSEKGWVRCAKGHEVDGKSLSYKAGDGFLRSAQGRSNQPSVFIDTSGRAF
ATETHTLPSARSQGEPITTRFNLASGATMEHLLLSDEEQCYLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLFP
QRVDKSKAQSILAITNEGRMLLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTSVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL
>Mature_754_residues
SDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLSAQSKHKKSARTVGDVLGKY
HPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKEP
LVLPARLPHILLNGITGIAVGMATDVPPHNVKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQT
GRGSIKARAVYTVENGEVVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHESPVRMVIVPRSNRVDCEQMMAH
LFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTFRMTTVKRRIEYRLDKILSRLHILDALMIAFLNIDEVIEIIR
YNDDPKAELISRFNLSDKQADAILDLKLRHLAKLEEFKIKAEQSELEAERDKLQLLLSSERRMKTLIKKELIKDSEDYGD
ERRSPLVERTESRALTEQELVPVESVTVVLSEKGWVRCAKGHEVDGKSLSYKAGDGFLRSAQGRSNQPSVFIDTSGRAFA
TETHTLPSARSQGEPITTRFNLASGATMEHLLLSDEEQCYLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLFPQ
RVDKSKAQSILAITNEGRMLLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTSVTLWAGKRKLTLKPSD
LEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=65.8998646820027, Blast_Score=1031, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=609, Percent_Identity=37.2742200328407, Blast_Score=378, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI212645845, Length=500, Percent_Identity=21.4, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84075; Mature: 83944

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELG
CCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKEPLVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECCHHHHHHHHHCHHHHE
VGMATDVPPHNVKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
EEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
TGRGSIKARAVYTVENGEVVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHES
CCCCCEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRMVIVPRSNRVDCEQMMAHLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTF
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
RMTTVKRRIEYRLDKILSRLHILDALMIAFLNIDEVIEIIRYNDDPKAELISRFNLSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHCCCCCHH
ADAILDLKLRHLAKLEEFKIKAEQSELEAERDKLQLLLSSERRMKTLIKKELIKDSEDYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
DERRSPLVERTESRALTEQELVPVESVTVVLSEKGWVRCAKGHEVDGKSLSYKAGDGFLR
HHHCCCHHHHHHHHCCCHHHCCCCCCEEEEEECCCCEEECCCCCCCCCCEEEECCCCHHC
SAQGRSNQPSVFIDTSGRAFATETHTLPSARSQGEPITTRFNLASGATMEHLLLSDEEQC
CCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCE
YLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLFPQRVDKSKAQSILAITNEGRM
EEEECCCCCEEEECCCHHHHCCCCCCEEEECCCCCEEECCCCCCHHHHCEEEEEECCCCE
LLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTSVTLWAGKRKLTLKPS
EEEECCCCCCCCCCCCCEEEECCCCCCCCHHHEEEEEEECCCCCEEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL
HHHHHCCCCCCCCCCCHHHHHHHCCEECCCCCCCC
>Mature Secondary Structure 
SDAIDLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELG
CCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVDWGVNFDGTMKEPLVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECCHHHHHHHHHCHHHHE
VGMATDVPPHNVKELVGACVELLDNPKADLARLMEFVPGPDYPTEAEIITPAADITKIYQ
EEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
TGRGSIKARAVYTVENGEVVITALPHQASSGKILEQIASQMQAKKLPMVTDLRDESDHES
CCCCCEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRMVIVPRSNRVDCEQMMAHLFATTDLQKSYRVNLNVLGLNGRPQVKGLLELLTEWLTF
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
RMTTVKRRIEYRLDKILSRLHILDALMIAFLNIDEVIEIIRYNDDPKAELISRFNLSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHCCCCCHH
ADAILDLKLRHLAKLEEFKIKAEQSELEAERDKLQLLLSSERRMKTLIKKELIKDSEDYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
DERRSPLVERTESRALTEQELVPVESVTVVLSEKGWVRCAKGHEVDGKSLSYKAGDGFLR
HHHCCCHHHHHHHHCCCHHHCCCCCCEEEEEECCCCEEECCCCCCCCCCEEEECCCCHHC
SAQGRSNQPSVFIDTSGRAFATETHTLPSARSQGEPITTRFNLASGATMEHLLLSDEEQC
CCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCE
YLLASDAGYGFICANKDMVSRNKAGKALLSLPANAKVLFPQRVDKSKAQSILAITNEGRM
EEEECCCCCEEEECCCHHHHCCCCCCEEEECCCCCEEECCCCCCHHHHCEEEEEECCCCE
LLFSLDALPQLSKGKGNKIIGIPGERAKNREELLLHLNVIPEDTSVTLWAGKRKLTLKPS
EEEECCCCCCCCCCCCCEEEECCCCCCCCHHHEEEEEEECCCCCEEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGEPVL
HHHHHCCCCCCCCCCCHHHHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]