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The map label for this gene is proA [H]

Identifier: 157962902

GI number: 157962902

Start: 3783022

End: 3784287

Strand: Reverse

Name: proA [H]

Synonym: Spea_3084

Alternate gene names: 157962902

Gene position: 3784287-3783022 (Counterclockwise)

Preceding gene: 157962903

Following gene: 157962901

Centisome position: 73.13

GC content: 48.34

Gene sequence:

>1266_bases
ATGAATAACGACGAATATTTAACGGCTTTAGGACAGAATGCTAAGCAGGCGAGTTATGCTTTGGCCACGTTATCGGGTCA
GCAAAAATCTGCGCTACTTCGCTGTATCGCTAATAAACTGACGGCTGCAAAAGATGACATCGTCGCGGCCAATCAGCAAG
ATGTTGCCGACGCTAAGGCTAATGGCCTATCGGATGCGATGATCGATCGTCTGTTACTCGATGAAACTAGACTGATGGGC
GTGATTAGCGACATCGATAACGTGATTGGCTTAACCGATCCGGTTGGCTGTGAAATCGATAGCCGCTTGTTAGACAACGG
TTTACGTTTATCACGCAGAAGAGTACCACTTGGGGTTATAGGTGTTATTTATGAGGCGCGTCCAAATGTGACCGTGGATA
TTGCCGTATTGGCCCTTAAAACAGGTAATGCGGTTATTCTACGCGGCGGTAAAGAGACGCTGTCATCGAATAAGGCACTT
TGTAAGGTGATCCGCAGTGCCATGGTCGAGCAAGGCTTGTCAGAAGATTGCGTGCAGTTGATTGATAACCCAGATAGAGC
CTTAGTTTCAGGTCTGCTAAAACTCGATAAATATGTCGATATGATCGTGCCACGCGGTGGCCAGAACTTGCAGCGCTTAT
GCGCCGAGCAAGCCACCATACCGGTGATCCTAGGTGGTATTGGTATTTGTCATATTTACGTGGATGCTGCAGCTAATCTT
GAGAAAGCGGTTGCAGTAATTGAAAACGCCAAAGTGCAACGCCCAACTGTGTGTAACGCCCTTGATACTGTGTTGGTTCA
CGCAAGCCATGCCAAGGCTTTCATTCCTGTTTTAGCTAAACATCTTAGCGGTTTAGGTGTGAAGTTCTACGGCTGTGAGC
AGACACAAGCCATTCTTGGCGCTGAGAAGATTGAGGTTTCAGCGGCAGATGATGAAAGTTACTCGACTGAATGGTTATCC
CTGACCTTAGGGCTCAAGGTCGTTGCTGATCTTGAAAGCGCAGTAGAGCATATTCGCACCTTCTCAAGCGGTCATTCAGA
GTCGATCCTAACTGACAATATTCATACTGCCAGCGAGTTTATGAATGCGGTTGATTCGGCCGCCGTGTACGTCAACGCAA
GTACCCGCTTTACCGATGGTGGTGAGTTTGGCCTAGGCGCCGAAGTGGCTGTGAGTACGCAAAAATTGCATGCGCGAGGA
CCTATGGGTCTAGAAGCATTGACCACATACAAGTGGTTAGCCTGGGGTGATTACACAGTGCGCTAG

Upstream 100 bases:

>100_bases
ATGTGACTAAACTTGCTGGTAAGCACTCAGATAGCATCGAAGAGGTGCTCGGGTATGATTATGGTGATGCAGTAGTTCAC
CGCAACGACATGGTGGTGTT

Downstream 100 bases:

>100_bases
TGGCGTTTGAAGGCCGATTTAAAAAAACCGCCTTGTGCGGTTTTTTTATTTTCAGCTCCCTTTCTTCAGAAGGGGGATTG
TTCACTTTGGCCGAATAGGG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIANKLTAAKDDIVAANQQDVADAKANGLSDAMIDRLLLDETRLMG
VISDIDNVIGLTDPVGCEIDSRLLDNGLRLSRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLSSNKAL
CKVIRSAMVEQGLSEDCVQLIDNPDRALVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAAANL
EKAVAVIENAKVQRPTVCNALDTVLVHASHAKAFIPVLAKHLSGLGVKFYGCEQTQAILGAEKIEVSAADDESYSTEWLS
LTLGLKVVADLESAVEHIRTFSSGHSESILTDNIHTASEFMNAVDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARG
PMGLEALTTYKWLAWGDYTVR

Sequences:

>Translated_421_residues
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIANKLTAAKDDIVAANQQDVADAKANGLSDAMIDRLLLDETRLMG
VISDIDNVIGLTDPVGCEIDSRLLDNGLRLSRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLSSNKAL
CKVIRSAMVEQGLSEDCVQLIDNPDRALVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAAANL
EKAVAVIENAKVQRPTVCNALDTVLVHASHAKAFIPVLAKHLSGLGVKFYGCEQTQAILGAEKIEVSAADDESYSTEWLS
LTLGLKVVADLESAVEHIRTFSSGHSESILTDNIHTASEFMNAVDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARG
PMGLEALTTYKWLAWGDYTVR
>Mature_421_residues
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIANKLTAAKDDIVAANQQDVADAKANGLSDAMIDRLLLDETRLMG
VISDIDNVIGLTDPVGCEIDSRLLDNGLRLSRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLSSNKAL
CKVIRSAMVEQGLSEDCVQLIDNPDRALVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAAANL
EKAVAVIENAKVQRPTVCNALDTVLVHASHAKAFIPVLAKHLSGLGVKFYGCEQTQAILGAEKIEVSAADDESYSTEWLS
LTLGLKVVADLESAVEHIRTFSSGHSESILTDNIHTASEFMNAVDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARG
PMGLEALTTYKWLAWGDYTVR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=36.5384615384615, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=36.5384615384615, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=59.0361445783133, Blast_Score=487, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17569967, Length=412, Percent_Identity=37.1359223300971, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17569969, Length=412, Percent_Identity=37.1359223300971, Blast_Score=268, Evalue=6e-72,
Organism=Saccharomyces cerevisiae, GI6324899, Length=425, Percent_Identity=38.8235294117647, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI21357643, Length=410, Percent_Identity=34.6341463414634, Blast_Score=252, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44985; Mature: 44985

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIANKLTAAKDDIVAANQQDVADAKA
CCCCCEEHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHC
NGLSDAMIDRLLLDETRLMGVISDIDNVIGLTDPVGCEIDSRLLDNGLRLSRRRVPLGVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHCCCEEEE
GVIYEARPNVTVDIAVLALKTGNAVILRGGKETLSSNKALCKVIRSAMVEQGLSEDCVQL
EEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
IDNPDRALVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAAANL
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCEEEEEEEHHHCCH
EKAVAVIENAKVQRPTVCNALDTVLVHASHAKAFIPVLAKHLSGLGVKFYGCEQTQAILG
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHC
AEKIEVSAADDESYSTEWLSLTLGLKVVADLESAVEHIRTFSSGHSESILTDNIHTASEF
HHHEEEEECCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHH
MNAVDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTYKWLAWGDYTV
HHHHCCEEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHEEEECCEEC
R
C
>Mature Secondary Structure
MNNDEYLTALGQNAKQASYALATLSGQQKSALLRCIANKLTAAKDDIVAANQQDVADAKA
CCCCCEEHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHC
NGLSDAMIDRLLLDETRLMGVISDIDNVIGLTDPVGCEIDSRLLDNGLRLSRRRVPLGVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHCCCEEEE
GVIYEARPNVTVDIAVLALKTGNAVILRGGKETLSSNKALCKVIRSAMVEQGLSEDCVQL
EEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
IDNPDRALVSGLLKLDKYVDMIVPRGGQNLQRLCAEQATIPVILGGIGICHIYVDAAANL
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCEEEEEEEHHHCCH
EKAVAVIENAKVQRPTVCNALDTVLVHASHAKAFIPVLAKHLSGLGVKFYGCEQTQAILG
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHC
AEKIEVSAADDESYSTEWLSLTLGLKVVADLESAVEHIRTFSSGHSESILTDNIHTASEF
HHHEEEEECCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHH
MNAVDSAAVYVNASTRFTDGGEFGLGAEVAVSTQKLHARGPMGLEALTTYKWLAWGDYTV
HHHHCCEEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHEEEECCEEC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA