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The map label for this gene is deoA [H]

Identifier: 157962865

GI number: 157962865

Start: 3737259

End: 3738590

Strand: Reverse

Name: deoA [H]

Synonym: Spea_3047

Alternate gene names: 157962865

Gene position: 3738590-3737259 (Counterclockwise)

Preceding gene: 157962866

Following gene: 157962864

Centisome position: 72.25

GC content: 47.0

Gene sequence:

>1332_bases
ATGTTTTTAGCTCAAGAAATTATTCGTAAAAAACGTAATGCTGAGACTCTTTCGACTGAAGAAATTCAATTCTTCGTTAA
AGGGATCACCAACAATACAGTTTCAGAAGGTCAGATCGCAGCCTTAGGCATGGCGGTCTATTTCAATGACATGAACATGG
ATGAACGTATTGCGTTAACTACGGCGATGCGTGACTCCGGCACAGTTCTCAACTGGCAATCACTGGATCTTAATGGTCCA
ATTATCGATAAGCACTCAACTGGCGGAGTGGGGGATGTCATTAGTTTGATGTTAGGCCCTATGGCGGCTGCGTGTGGTGG
TTATGTACCCATGATCTCGGGTCGTGGCCTTGGCCATACCGGTGGTACTCTCGATAAGTTTGATGCCATTCCAGGTTATA
ATACCGAGCCGGACAGCGCACTGTTTCGCAAGGTAGTAAAAGAGGCTGGCGTGGCCATTATTGGTCAAACTGGCGATCTG
GTTCCTGCCGATAAACGTTTCTATTCTATTCGCGATAATACCGCAACGGTTGAGTCCATCTCTTTAATCACAGCTTCCAT
TCTTTCTAAAAAGCTCGCCGCAGGTTTAGATGCATTAGCCATGGACGTTAAAGTCGGTACTGGCGCATTTATGCCAACCT
ATGAAGCGTCAGAAGAGTTAGCGCGCAGTATTACTGCCGTTGCTAATGGTGCAGGCACTAAGACAACAGCATTACTCACC
GACATGAACCAGGTATTGGCATCATGTGCCGGTAACGCATTAGAAGTTAAAGAAGCAGTCGACTTTATGACTGGTGCATA
TCGCAACCCACGCCTTTACGAAGTGACTATGGGCTTGTGTGCAGAAATGCTGGTATTAGGTGGCCTTGCAAGCAACGAGA
GCGAAGCTCGCGTTAAGTTAAATACCGTACTTGATAACGGTAAGGCGGCTGAGATATTCGGCCGTATGGTTTCAGGTTTA
GGTGGTCCAGCTGATTTCGTTGAGAACTACAGCAAGTACCTGCCTGATTCGCAAATTATTCGTCCTGTTTACGCGGATAG
ATCCGGTTTTGCTTCGGCAATGGATACCCGTGAACTTGGACTTGCAGTAGTGACCTTGGGCGGTGGTCGCCGCAAGCCTG
GGGATGCTCTCGATTACAGTGTTGGACTTTCTAAAGTTTGCGCACTAGGTGACGAGATTAACCCTGAGCAACCTATTGCA
TTTATTCACGCCCAATCTGAAAGCGCCTTTGCTGAAGCGGAAGCTGCAGTGAAAAAAGCGATTCATATTGGCGACAGCAA
ACCAGAGAAAACTCCGGAAATATATCGTTATATCCGCGAGTCAGATCTGTAA

Upstream 100 bases:

>100_bases
GTTAGTATGTAACAATATTACGACTTTTGATTCGCTTTAGCGGATTGATAACTGAAAATACTATTTAATAGAAATTCAGT
TACACTCTTGGAGGTAGTAC

Downstream 100 bases:

>100_bases
CGGAGCACCGTTTATGAAACGTACTATAATCATGATGCTGGATTCTTTCGGCGTTGGCGCAGCGCACGATGCCGAAGCTT
TCGGTGATGTGGGTTCTAAC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLAQEIIRKKRNAETLSTEEIQFFVKGITNNTVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLDLNGP
IIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGTGAFMPTYEASEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNALEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGLASNESEARVKLNTVLDNGKAAEIFGRMVSGL
GGPADFVENYSKYLPDSQIIRPVYADRSGFASAMDTRELGLAVVTLGGGRRKPGDALDYSVGLSKVCALGDEINPEQPIA
FIHAQSESAFAEAEAAVKKAIHIGDSKPEKTPEIYRYIRESDL

Sequences:

>Translated_443_residues
MFLAQEIIRKKRNAETLSTEEIQFFVKGITNNTVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLDLNGP
IIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGTGAFMPTYEASEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNALEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGLASNESEARVKLNTVLDNGKAAEIFGRMVSGL
GGPADFVENYSKYLPDSQIIRPVYADRSGFASAMDTRELGLAVVTLGGGRRKPGDALDYSVGLSKVCALGDEINPEQPIA
FIHAQSESAFAEAEAAVKKAIHIGDSKPEKTPEIYRYIRESDL
>Mature_443_residues
MFLAQEIIRKKRNAETLSTEEIQFFVKGITNNTVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLDLNGP
IIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLAAGLDALAMDVKVGTGAFMPTYEASEELARSITAVANGAGTKTTALLT
DMNQVLASCAGNALEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGLASNESEARVKLNTVLDNGKAAEIFGRMVSGL
GGPADFVENYSKYLPDSQIIRPVYADRSGFASAMDTRELGLAVVTLGGGRRKPGDALDYSVGLSKVCALGDEINPEQPIA
FIHAQSESAFAEAEAAVKKAIHIGDSKPEKTPEIYRYIRESDL

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=442, Percent_Identity=37.7828054298643, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI4503445, Length=442, Percent_Identity=37.7828054298643, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI166158922, Length=442, Percent_Identity=37.7828054298643, Blast_Score=269, Evalue=4e-72,
Organism=Escherichia coli, GI1790842, Length=440, Percent_Identity=67.5, Blast_Score=620, Evalue=1e-179,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 47077; Mature: 47077

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRNAETLSTEEIQFFVKGITNNTVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLDLNGPIIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLAAGLDALAMDVKVGTGAFMPTYEASEELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNALEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGLASNESEARVKL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEEE
NTVLDNGKAAEIFGRMVSGLGGPADFVENYSKYLPDSQIIRPVYADRSGFASAMDTRELG
EEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCC
LAVVTLGGGRRKPGDALDYSVGLSKVCALGDEINPEQPIAFIHAQSESAFAEAEAAVKKA
EEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IHIGDSKPEKTPEIYRYIRESDL
HHCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFLAQEIIRKKRNAETLSTEEIQFFVKGITNNTVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLDLNGPIIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYNTEPDSALFRKVVKEAGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLAAGLDALAMDVKVGTGAFMPTYEASEELARSITAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNALEVKEAVDFMTGAYRNPRLYEVTMGLCAEMLVLGGLASNESEARVKL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEEE
NTVLDNGKAAEIFGRMVSGLGGPADFVENYSKYLPDSQIIRPVYADRSGFASAMDTRELG
EEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCC
LAVVTLGGGRRKPGDALDYSVGLSKVCALGDEINPEQPIAFIHAQSESAFAEAEAAVKKA
EEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
IHIGDSKPEKTPEIYRYIRESDL
HHCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA