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The map label for this gene is mepA [H]

Identifier: 157962818

GI number: 157962818

Start: 3676168

End: 3677544

Strand: Reverse

Name: mepA [H]

Synonym: Spea_3000

Alternate gene names: 157962818

Gene position: 3677544-3676168 (Counterclockwise)

Preceding gene: 157962819

Following gene: 157962817

Centisome position: 71.07

GC content: 48.66

Gene sequence:

>1377_bases
ATGACCATGAGCCAACCTATGCCACCGGCGGGAACTAATCGAGTCGCAACCGACTCGCCAATGATCACCGAGCCAATCGG
AAAACTGTTTTGGCGCTATTCACTCCCTACGATCCTCTCAATGTTAGTGACGGGAATATACGTCACCATCGACGGCATGT
TTATTGGGCACTACCTCGGGGAAGTCGGCTTAGCGGGCATGATTTTGGCTTACCCTATCGCTGCTGTGCTCTACGCGATT
GGCGCAACGCTGGGAATGGGCGGCGCTGCTTTAGTGTCGATTCATCTGGGGCAAGGTGAAACTAGCATTGCTCGGCGCAT
ATTGGGCAATACTTTTAGTCTGTGCCTTATCTCGGGCCTTATCACCACAGTACTCGGTTGCTACTTTTCTAGAGATATCT
TGATGATGCTCGGCGCTGAAGGTGAGATCCTAAATAGCGCCGACGACTATCTTTTTTGGTATTTTGCCCTAGGCACTTTC
CCCATAGTGTCGATGGCATTTACTGCATTGCTGCGTAATGATGGTCGGCCCGGATTCGTGACTTTCGTTTTGATCTTAGG
TGGCGTGCTAAATACAGTGCTCGATTGGTTGTTAATCGTGGTGTTCCCTTATGGGTTAATGGGCGCAGCGATAGCCACCA
TGATTTCCCAAGCGGTGACGGGGGCCCTGTGTTTACAGCATTTCTTCAGTAGTAAAACCGAGATAGGCATCAACCTTGAG
CAGATGAAGCTCAAATGGGATCACTGCGCCAATATCATTCGTGTAGGTACCCCAAGTTTCTTGATGAACATGTACTTGAC
CGTGGTGCTGACGCTACACAATGTGGCATTTCTTACGGTAGGCACGCCGCTGCATGTTGCTGCCTATGGGGTCGTGAGTT
ATACCGAAGCCTTCTTTTACCTCTTATTTGAAGGTATCGCTTTTGGCGTACAGCCTATTTTGAGTTTTAATGCTGGTGCC
AAACGCTTCGATAGGGTTAAACAGGCACTTAAAATGGCCTTCTCTGTGACCTTAGTGTGCGCCGCCTTAGGTCTCGTCTT
TATCTATTCTGTGCCGCAACTTTTTGTCTATATCTTTGCCGGTGACAACGACTTACTCACGCCGATAGCCATCGAGGGAA
TGCGTTGGTATTTCTGGGGCTTACCTATGGAAGGCTTGTTATTAGTGGGTGCATCATTTTTCCAAGCAATTAATTACTCA
AAAGAAGCATCGATTTTAACCGGGGCCAAGCTGATCCTGTTTAGCGCTATCTTGTGTGTGTTTGCCTGGGCATTTGGTGT
GACAGGGGTGTGGATCTCACTGGCTACTTGTAGCACGGTATTAGCCATCTGGATGGGCTGGATAATGAAGCGTACTCATA
GCAAGCTGTTAGCCTAA

Upstream 100 bases:

>100_bases
CGCGACTATTTTAAGTATTTTATAAGCGATTAAGCTGTAGAGCTGTCATTTGTAAATCTGTAATCCGTAAGCCAGTGAAA
AAAATAACAATAATAAGAGA

Downstream 100 bases:

>100_bases
TATTGACTTGTAGAACATAGGTACACGGCGTAACCCGTTAATTTTAATTTAATTGTTACTAAATTAACGGGGGCTGCTCA
GCTTGCTTATAAGTTAGTCG

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTMSQPMPPAGTNRVATDSPMITEPIGKLFWRYSLPTILSMLVTGIYVTIDGMFIGHYLGEVGLAGMILAYPIAAVLYAI
GATLGMGGAALVSIHLGQGETSIARRILGNTFSLCLISGLITTVLGCYFSRDILMMLGAEGEILNSADDYLFWYFALGTF
PIVSMAFTALLRNDGRPGFVTFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSKTEIGINLE
QMKLKWDHCANIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFYLLFEGIAFGVQPILSFNAGA
KRFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFAGDNDLLTPIAIEGMRWYFWGLPMEGLLLVGASFFQAINYS
KEASILTGAKLILFSAILCVFAWAFGVTGVWISLATCSTVLAIWMGWIMKRTHSKLLA

Sequences:

>Translated_458_residues
MTMSQPMPPAGTNRVATDSPMITEPIGKLFWRYSLPTILSMLVTGIYVTIDGMFIGHYLGEVGLAGMILAYPIAAVLYAI
GATLGMGGAALVSIHLGQGETSIARRILGNTFSLCLISGLITTVLGCYFSRDILMMLGAEGEILNSADDYLFWYFALGTF
PIVSMAFTALLRNDGRPGFVTFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSKTEIGINLE
QMKLKWDHCANIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFYLLFEGIAFGVQPILSFNAGA
KRFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFAGDNDLLTPIAIEGMRWYFWGLPMEGLLLVGASFFQAINYS
KEASILTGAKLILFSAILCVFAWAFGVTGVWISLATCSTVLAIWMGWIMKRTHSKLLA
>Mature_457_residues
TMSQPMPPAGTNRVATDSPMITEPIGKLFWRYSLPTILSMLVTGIYVTIDGMFIGHYLGEVGLAGMILAYPIAAVLYAIG
ATLGMGGAALVSIHLGQGETSIARRILGNTFSLCLISGLITTVLGCYFSRDILMMLGAEGEILNSADDYLFWYFALGTFP
IVSMAFTALLRNDGRPGFVTFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSKTEIGINLEQ
MKLKWDHCANIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFYLLFEGIAFGVQPILSFNAGAK
RFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFAGDNDLLTPIAIEGMRWYFWGLPMEGLLLVGASFFQAINYSK
EASILTGAKLILFSAILCVFAWAFGVTGVWISLATCSTVLAIWMGWIMKRTHSKLLA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49824; Mature: 49693

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TMSQPMPPAGTNRVATDSPMITEPIGKLFWRYSLPTILSMLVTGIYVTIDGMFIGHYLG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVGLAGMILAYPIAAVLYAIGATLGMGGAALVSIHLGQGETSIARRILGNTFSLCLISGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHH
ITTVLGCYFSRDILMMLGAEGEILNSADDYLFWYFALGTFPIVSMAFTALLRNDGRPGFV
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TFVLILGGVLNTVLDWLLIVVFPYGLMGAAIATMISQAVTGALCLQHFFSSKTEIGINLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
QMKLKWDHCANIIRVGTPSFLMNMYLTVVLTLHNVAFLTVGTPLHVAAYGVVSYTEAFFY
HHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHH
LLFEGIAFGVQPILSFNAGAKRFDRVKQALKMAFSVTLVCAALGLVFIYSVPQLFVYIFA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
GDNDLLTPIAIEGMRWYFWGLPMEGLLLVGASFFQAINYSKEASILTGAKLILFSAILCV
CCCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FAWAFGVTGVWISLATCSTVLAIWMGWIMKRTHSKLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA