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The map label for this gene is uppS [H]

Identifier: 157962700

GI number: 157962700

Start: 3519854

End: 3520654

Strand: Reverse

Name: uppS [H]

Synonym: Spea_2881

Alternate gene names: 157962700

Gene position: 3520654-3519854 (Counterclockwise)

Preceding gene: 157962701

Following gene: 157962699

Centisome position: 68.04

GC content: 45.07

Gene sequence:

>801_bases
ATGTCAATCGATTCCCAGTCTGACACTGAAGTGACACAGACCTTACCAAGCGAAATATCCGCCTTGGTAAAACAGTCGAT
CCCTAAACATGTTGCTATCATCATGGATGGTAACGGGCGTTGGGCACAGGCTCAGGGAAAGCCTCGAGTTATTGGCCATA
AAGCTGGTGTGAAGGCTGTTAGACGAGCAGTAAGTACGGCCCGTAATTTAGGGGTTGAATCATTAACTTTGTTTGCGTTT
TCTAGCGAAAACTGGCGCAGACCTGACAAAGAAGTCAGTTTGTTAATGGAACTATTTTTTACCGTGTTGCAGCGTGAACT
TAAGTTGCTGCACAACAATGGGGTTCGCCTCAATATTATCGGTGATATCAGTCGATTTTCTCCGCGTTTGCAAAAGCAAA
TTGCTGCGGCAGAAGAGAAAACGGCCGACAATAAAGATTTAGTGCTTAACGTGGCAGCCAACTATGGTGGCCGTTGGGAC
ATTATGCAAGCGGCACAAAAATTGGCTGCGAAGGTTGAATCTGGCGAAATGAGCAGCACTCAGTTTACCGAAGAGGCCTT
AAGTGAGCATTTGTGCATGCAAAATCAAGCCGAAGTTGATTTAATGATCCGTACCGGTGGTGACTATCGCATAAGTAATT
TTGTCTTGTGGCAAGCTGCTTATGCTGAGTTAGTCTTTACTGACACCTTGTGGCCGGATTTTGATGAGGATGCGTTTAAA
GACGCGATTGCTATTTTTGCTAATCGTCAGCGTCGATTCGGTTTGACAGGAACTCAAATCGATACCATCCGATCTTTGTA
A

Upstream 100 bases:

>100_bases
TGAGTAAAAATTGAACTCGAATAGTCAACATGCCCTAGAGTTAAGACGCCGTGTAGAGGTATACTACACGGCGTTTGTCT
ATTTTTAAGGGTTGTAATAG

Downstream 100 bases:

>100_bases
TAATTTGTGAGGGAAGTTTTTTGCTAAAACAACGAATAATAACAGCAATTTGGTTAATCCCCTTAGTTTTTGGTGCCATC
TTCGGTCTACCTACTGAGTA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSIDSQSDTEVTQTLPSEISALVKQSIPKHVAIIMDGNGRWAQAQGKPRVIGHKAGVKAVRRAVSTARNLGVESLTLFAF
SSENWRRPDKEVSLLMELFFTVLQRELKLLHNNGVRLNIIGDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWD
IMQAAQKLAAKVESGEMSSTQFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEDAFK
DAIAIFANRQRRFGLTGTQIDTIRSL

Sequences:

>Translated_266_residues
MSIDSQSDTEVTQTLPSEISALVKQSIPKHVAIIMDGNGRWAQAQGKPRVIGHKAGVKAVRRAVSTARNLGVESLTLFAF
SSENWRRPDKEVSLLMELFFTVLQRELKLLHNNGVRLNIIGDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWD
IMQAAQKLAAKVESGEMSSTQFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEDAFK
DAIAIFANRQRRFGLTGTQIDTIRSL
>Mature_265_residues
SIDSQSDTEVTQTLPSEISALVKQSIPKHVAIIMDGNGRWAQAQGKPRVIGHKAGVKAVRRAVSTARNLGVESLTLFAFS
SENWRRPDKEVSLLMELFFTVLQRELKLLHNNGVRLNIIGDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWDI
MQAAQKLAAKVESGEMSSTQFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEDAFKD
AIAIFANRQRRFGLTGTQIDTIRSL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=211, Percent_Identity=35.5450236966825, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI45580742, Length=211, Percent_Identity=35.5450236966825, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=63.5964912280702, Blast_Score=303, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI71993029, Length=215, Percent_Identity=32.5581395348837, Blast_Score=120, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=33.6322869955157, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=34.4186046511628, Blast_Score=118, Evalue=9e-28,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=35.8851674641148, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29746; Mature: 29615

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDSQSDTEVTQTLPSEISALVKQSIPKHVAIIMDGNGRWAQAQGKPRVIGHKAGVKAV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCEECCHHHHHHH
RRAVSTARNLGVESLTLFAFSSENWRRPDKEVSLLMELFFTVLQRELKLLHNNGVRLNII
HHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
GDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWDIMQAAQKLAAKVESGEMSST
CCHHHHCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHH
QFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEDAFK
HHHHHHHHHHHHCCCCCCEEEEEECCCCEEEHHEEHHHHHHHHHHEECCCCCCCCHHHHH
DAIAIFANRQRRFGLTGTQIDTIRSL
HHHHHHHCCCHHCCCCCCHHHHHHCC
>Mature Secondary Structure 
SIDSQSDTEVTQTLPSEISALVKQSIPKHVAIIMDGNGRWAQAQGKPRVIGHKAGVKAV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCEECCHHHHHHH
RRAVSTARNLGVESLTLFAFSSENWRRPDKEVSLLMELFFTVLQRELKLLHNNGVRLNII
HHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
GDISRFSPRLQKQIAAAEEKTADNKDLVLNVAANYGGRWDIMQAAQKLAAKVESGEMSST
CCHHHHCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHH
QFTEEALSEHLCMQNQAEVDLMIRTGGDYRISNFVLWQAAYAELVFTDTLWPDFDEDAFK
HHHHHHHHHHHHCCCCCCEEEEEECCCCEEEHHEEHHHHHHHHHHEECCCCCCCCHHHHH
DAIAIFANRQRRFGLTGTQIDTIRSL
HHHHHHHCCCHHCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]