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The map label for this gene is cvrA [H]

Identifier: 157962221

GI number: 157962221

Start: 2926979

End: 2928856

Strand: Reverse

Name: cvrA [H]

Synonym: Spea_2400

Alternate gene names: 157962221

Gene position: 2928856-2926979 (Counterclockwise)

Preceding gene: 157962222

Following gene: 157962220

Centisome position: 56.6

GC content: 46.22

Gene sequence:

>1878_bases
ATGCTGGAGCAGATCACTGCGATGCTTGCTTTGCTAGGTGTGTTATCGTTGTTTTGTCAGTGGATAGGGTGGAAATTGAG
ACTACCTGCCATTTTACCCCTGTTACTATGCGGCCTCCTGCTTGGACCAGGTCTTGGTTTCTTACAGCCAGATGTTATTT
TTGGCGACTTGTTGTTCCCTATCATCTCTCTTGGTGTTGCGGTCATTCTTTTTGAAGGTGCATTAACCCTTAACTTCAAA
GAAATAAAAGAGCACGGTGTTATGGTGACCCGCTTGGTGACACTCGGCACTGTGATCACTTGGGCCTGTATTACGGTCGG
CACCTTCTATCTACTCGATTTCGAATGGTCAATGGCGCTTTTATTTGGTGCCTTGGTCGTGGTAACTGGTCCGACTGTTA
TTGTGCCTATGCTTCGAAGTGTAAGACCAAAAACTGAACTTGCGAGTATATTGCGCTGGGAAGGGATAGTCATCGACCCA
ATAGGTGCGCTGCTTGCCGTGTTGGTGTTTGAATATATCGCGGTTGCGGCCGACCCAACCACACATGTTCTGCATGCTTT
AAGTGCCATGTTGGCCGTTGGTCTTGGCTTTGGTGTGATAAGTGGCTATTTAGTTGGCCTCGTTTTGCGTAATAATCTAT
TGCCACACTATTTGCGTAATACGGCTGTTCTCACCCTAATGCTAGCGGTTTTCGTTGGCTCAAACCTATTACAAGAAGAA
GCCGGTTTGCTCTCGGTGACCGTGATGGGCATTTGGCTGGCGAACATGAAAGGCGTGGATATTGCCGATATTCTCGAGTT
TAAAGAGACCCTGACGGTATTACTTATTTCTGCGTTGTTTATATTACTTGCGGCAAGACTCAATGCCGATGCGCTGTTAA
GCCTAGGCTGGGAAGGCTTAGCACTACTCGCGGTGGTGATGTTAATTGCACGTCCCTTAAGTATCTGGTGTTGTGGCATC
GGTACCTCGCTTTCAAAGGGGGATAAATGGTTTTTAAGCTGGGTCGCACCACGAGGTATTGTCGCAGCGGCCGTGTCATC
CTTATTTGCCATTAAATTGGAAGCTATCGGCATTAAAGGCGCGGAGCTTATCGTACCTTTAGTCTTCCTCATTATTATTG
GTACTGTAGTGATCCAAAGCTTAACTGCGGGGAGGTGGGCTAAGGTACTCGGCGTTACCGCAGACTCCTCTCAAGGGTTA
TTAATTTTCGGTGCATCCAAGTTTCCACGAGCACTGGCTAAAACATTGCAGTCAAAGGGGGTCACTGTGCTGCTTGCCGA
TAATAACTGGGATAATGTTCGCTTAGCCCGTATGGATAGCATTCCAGTATATTTCGGTAATCCAGCATCGGAACACGCCG
AGAATCATATGAATATGGCGGGAATAGGTCGAGTTCTGGTGATGTCGCCATATAGGCAGCTTAATCCTCTCGTAACTTTC
TATTTTCAAGATGTATTTGGTAGTAAAAAAGTTTTTGGACTCAATAATGGTGAAATCTCAAGTGCAAGGCATCAATTATC
TGAGTCTTACTTGGAACGCTTAAGTTTATTTGGTGATGATGTCTCTTACTCTAAGCTCGCAAGCTTAATGGCAAAGGGGG
CAACCATTAAAAGCACCCGTCTCACTGAGAACTTCAATTACGCTATGTTTATGAAGCAGTATGCAGAAGCTGCCATCCCG
CTTATTTACCTGCAAGAGGGGAAGGTGAGGTTGATTAGCGGTGAACTTGAGATACCGATAGGAGTCGAGTTAATCAGCTT
AATCCCCGTGGATGCAATCAAGTTAGACTGTAACAGTGACAACCATCCTGACACTGGGGAGACAAGTTCGACTGTTATAG
CTGATGAGAATCTGGCTGTCAGCAAGGCACCTGAGTGA

Upstream 100 bases:

>100_bases
GTTATCGTATTTTACTCAGGTTTGACTATAGTTTTTACACTCAACTGCATGTTTTAACAAACATCGTTTCAATAGAAACG
ATCAGATAAGGAAATAGGCT

Downstream 100 bases:

>100_bases
CAAGTGAGTGTGGTCGATTTAGTCAGGCATCTATCGATGTAGAGTTGATTTATTGAGTTAATTCGGTCTTCCTGTGAAGG
CCGAATCTAATTCTGTTAGT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLQPDVIFGDLLFPIISLGVAVILFEGALTLNFK
EIKEHGVMVTRLVTLGTVITWACITVGTFYLLDFEWSMALLFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDP
IGALLAVLVFEYIAVAADPTTHVLHALSAMLAVGLGFGVISGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
AGLLSVTVMGIWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGLALLAVVMLIARPLSIWCCGI
GTSLSKGDKWFLSWVAPRGIVAAAVSSLFAIKLEAIGIKGAELIVPLVFLIIIGTVVIQSLTAGRWAKVLGVTADSSQGL
LIFGASKFPRALAKTLQSKGVTVLLADNNWDNVRLARMDSIPVYFGNPASEHAENHMNMAGIGRVLVMSPYRQLNPLVTF
YFQDVFGSKKVFGLNNGEISSARHQLSESYLERLSLFGDDVSYSKLASLMAKGATIKSTRLTENFNYAMFMKQYAEAAIP
LIYLQEGKVRLISGELEIPIGVELISLIPVDAIKLDCNSDNHPDTGETSSTVIADENLAVSKAPE

Sequences:

>Translated_625_residues
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLQPDVIFGDLLFPIISLGVAVILFEGALTLNFK
EIKEHGVMVTRLVTLGTVITWACITVGTFYLLDFEWSMALLFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDP
IGALLAVLVFEYIAVAADPTTHVLHALSAMLAVGLGFGVISGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
AGLLSVTVMGIWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGLALLAVVMLIARPLSIWCCGI
GTSLSKGDKWFLSWVAPRGIVAAAVSSLFAIKLEAIGIKGAELIVPLVFLIIIGTVVIQSLTAGRWAKVLGVTADSSQGL
LIFGASKFPRALAKTLQSKGVTVLLADNNWDNVRLARMDSIPVYFGNPASEHAENHMNMAGIGRVLVMSPYRQLNPLVTF
YFQDVFGSKKVFGLNNGEISSARHQLSESYLERLSLFGDDVSYSKLASLMAKGATIKSTRLTENFNYAMFMKQYAEAAIP
LIYLQEGKVRLISGELEIPIGVELISLIPVDAIKLDCNSDNHPDTGETSSTVIADENLAVSKAPE
>Mature_625_residues
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLQPDVIFGDLLFPIISLGVAVILFEGALTLNFK
EIKEHGVMVTRLVTLGTVITWACITVGTFYLLDFEWSMALLFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDP
IGALLAVLVFEYIAVAADPTTHVLHALSAMLAVGLGFGVISGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
AGLLSVTVMGIWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGLALLAVVMLIARPLSIWCCGI
GTSLSKGDKWFLSWVAPRGIVAAAVSSLFAIKLEAIGIKGAELIVPLVFLIIIGTVVIQSLTAGRWAKVLGVTADSSQGL
LIFGASKFPRALAKTLQSKGVTVLLADNNWDNVRLARMDSIPVYFGNPASEHAENHMNMAGIGRVLVMSPYRQLNPLVTF
YFQDVFGSKKVFGLNNGEISSARHQLSESYLERLSLFGDDVSYSKLASLMAKGATIKSTRLTENFNYAMFMKQYAEAAIP
LIYLQEGKVRLISGELEIPIGVELISLIPVDAIKLDCNSDNHPDTGETSSTVIADENLAVSKAPE

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 67472; Mature: 67472

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLQPDVIFGDLLFP
CHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
IISLGVAVILFEGALTLNFKEIKEHGVMVTRLVTLGTVITWACITVGTFYLLDFEWSMAL
HHHHHHHHHHHHCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHH
LFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDPIGALLAVLVFEYIAVAADPT
HHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHCCCCH
THVLHALSAMLAVGLGFGVISGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
AGLLSVTVMGIWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHH
ALLAVVMLIARPLSIWCCGIGTSLSKGDKWFLSWVAPRGIVAAAVSSLFAIKLEAIGIKG
HHHHHHHHHHCCHHEEEECCCCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHEECCCC
AELIVPLVFLIIIGTVVIQSLTAGRWAKVLGVTADSSQGLLIFGASKFPRALAKTLQSKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHCC
VTVLLADNNWDNVRLARMDSIPVYFGNPASEHAENHMNMAGIGRVLVMSPYRQLNPLVTF
CEEEEECCCCCCEEEEEECCCCEEECCCHHHHHHHCCCHHHHCHHEEECCHHHHCHHHHH
YFQDVFGSKKVFGLNNGEISSARHQLSESYLERLSLFGDDVSYSKLASLMAKGATIKSTR
HHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCC
LTENFNYAMFMKQYAEAAIPLIYLQEGKVRLISGELEIPIGVELISLIPVDAIKLDCNSD
CCCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCHHHHHHCCCCEEEEECCCC
NHPDTGETSSTVIADENLAVSKAPE
CCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MLEQITAMLALLGVLSLFCQWIGWKLRLPAILPLLLCGLLLGPGLGFLQPDVIFGDLLFP
CHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
IISLGVAVILFEGALTLNFKEIKEHGVMVTRLVTLGTVITWACITVGTFYLLDFEWSMAL
HHHHHHHHHHHHCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHH
LFGALVVVTGPTVIVPMLRSVRPKTELASILRWEGIVIDPIGALLAVLVFEYIAVAADPT
HHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHCCCCH
THVLHALSAMLAVGLGFGVISGYLVGLVLRNNLLPHYLRNTAVLTLMLAVFVGSNLLQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
AGLLSVTVMGIWLANMKGVDIADILEFKETLTVLLISALFILLAARLNADALLSLGWEGL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHH
ALLAVVMLIARPLSIWCCGIGTSLSKGDKWFLSWVAPRGIVAAAVSSLFAIKLEAIGIKG
HHHHHHHHHHCCHHEEEECCCCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHEECCCC
AELIVPLVFLIIIGTVVIQSLTAGRWAKVLGVTADSSQGLLIFGASKFPRALAKTLQSKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCCCCCEEEEECCHHHHHHHHHHHHCC
VTVLLADNNWDNVRLARMDSIPVYFGNPASEHAENHMNMAGIGRVLVMSPYRQLNPLVTF
CEEEEECCCCCCEEEEEECCCCEEECCCHHHHHHHCCCHHHHCHHEEECCHHHHCHHHHH
YFQDVFGSKKVFGLNNGEISSARHQLSESYLERLSLFGDDVSYSKLASLMAKGATIKSTR
HHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCC
LTENFNYAMFMKQYAEAAIPLIYLQEGKVRLISGELEIPIGVELISLIPVDAIKLDCNSD
CCCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCHHHHHHCCCCEEEEECCCC
NHPDTGETSSTVIADENLAVSKAPE
CCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]