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The map label for this gene is serS [H]

Identifier: 157962050

GI number: 157962050

Start: 2701154

End: 2702440

Strand: Reverse

Name: serS [H]

Synonym: Spea_2229

Alternate gene names: 157962050

Gene position: 2702440-2701154 (Counterclockwise)

Preceding gene: 157962051

Following gene: 157962049

Centisome position: 52.23

GC content: 44.76

Gene sequence:

>1287_bases
ATGTTAGATCCAAAATTTTTACGCAGTGAATTAGAAATGACCGCCGAGCGCCTTGCGACTCGTGGTTTTATTTTAGACGT
TGAGCGTCTAAGCAAACTTGAAGAAACTCGCAAGTCTTTGCAGGTTGCAACCGAAGAGCTACAAGCGTCGCGTAACGCTA
TCTCTAAGTCGATTGGCCAAGCTAAAGCTAAAGGCGAAGATGTTGCACCTATCATGGCTCAAGTTGGTTCCCTAGGCGAA
GAGCTTGATGCTAAGAAGACTGAATTAGCTGCACTACTTGAAGAGCTAAACGCTATCGCAATGAGCGTGCCGAACTTACC
TGATGAGTCAGTACCAACGGGTGCAGATGAGTCTGAAAACGTCGAAGTTCGCCGTTGGGGCACACCAAAAGAGTTCGATT
TCGCAGTCAAAGATCATGTTGAACTTGGTGAAAATATTGGTGGTTTAGACTTTAAAAACGCCGTGAAGATTACAGGTTCG
CGCTTTATCGTGATGAAGGGGCAAATTGCTCGCATGCACCGTGCTTTAGCACAATTCATGTTAGACCTTCATACAACAGA
ACATGGTTACACTGAAGCGTATGTACCTTTGCTAGTGAATGAAGACAGTTTATTAGGAACGGGTCAGTTACCTAAATTTG
GTGAAGACTTATTTCATACCAAACCTGCGACTGAAGAAGGCCAAGGTCTAAGTCTAATTCCAACAGCTGAAGTGCCACTG
ACTAACTTAGTTCGTGACACTATCGTTGAAGAAGATAATTTACCAATCAAACTGACTGCACATACACCTTGTTTTAGAAG
TGAAGCGGGCTCTTATGGCCGTGATACTCGTGGTTTGATCCGCCAACATCAGTTTGACAAAGTTGAAATGGTTCAGCTTG
TTAAGCCCGAAGATTCAATGCAGGCCTTAGAAGACTTAACGGGCCATGCTGAAGTCGTTCTGCAGAAGCTAGGTCTACCA
TACCGTACAATGGTTTTATGTACTGGTGACATGGGCTTTGGCTCTGCGAAAACTTACGACATCGAAGTTTGGTTGCCAGC
GCAGGATACTTACCGTGAGATTTCATCTTGCAGTAACATGCAAGACTTCCAAGCGCGTCGTATGCAAGCGCGCTACAAAG
GTAAAACTGACAAGAAGCCAAGCTTACTACACACATTGAATGGTTCAGGCTTAGCTGTTGGCCGTACGTTAGTGGCTGTA
CTTGAAAACTACCAGAATGCAGATGGTTCTATCACAGTGCCAGAAGCATTACGCGGTTACATGGGCGGCCTAAAAAAAAT
CGGTTAA

Upstream 100 bases:

>100_bases
CGTATTCAATGTTGTTGTTAATGTCGGCGTTTGTATTTTTGTCGTTTATCTGGGACAGCAATTGGTGTTTTCTCGTTTTT
AACTATTAAGATAATAAAAT

Downstream 100 bases:

>100_bases
TCCCTGTTATTTCTAGTCGTTATCGATAAAAAGCCTTCACTTTTGTGAAGGCTTTTTGTTTTGCTCTAACGATAGAGTTC
CGCAATTATATTATTGTTAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDPKFLRSELEMTAERLATRGFILDVERLSKLEETRKSLQVATEELQASRNAISKSIGQAKAKGEDVAPIMAQVGSLGE
ELDAKKTELAALLEELNAIAMSVPNLPDESVPTGADESENVEVRRWGTPKEFDFAVKDHVELGENIGGLDFKNAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTTEHGYTEAYVPLLVNEDSLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDTIVEEDNLPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQLVKPEDSMQALEDLTGHAEVVLQKLGLP
YRTMVLCTGDMGFGSAKTYDIEVWLPAQDTYREISSCSNMQDFQARRMQARYKGKTDKKPSLLHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEALRGYMGGLKKIG

Sequences:

>Translated_428_residues
MLDPKFLRSELEMTAERLATRGFILDVERLSKLEETRKSLQVATEELQASRNAISKSIGQAKAKGEDVAPIMAQVGSLGE
ELDAKKTELAALLEELNAIAMSVPNLPDESVPTGADESENVEVRRWGTPKEFDFAVKDHVELGENIGGLDFKNAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTTEHGYTEAYVPLLVNEDSLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDTIVEEDNLPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQLVKPEDSMQALEDLTGHAEVVLQKLGLP
YRTMVLCTGDMGFGSAKTYDIEVWLPAQDTYREISSCSNMQDFQARRMQARYKGKTDKKPSLLHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEALRGYMGGLKKIG
>Mature_428_residues
MLDPKFLRSELEMTAERLATRGFILDVERLSKLEETRKSLQVATEELQASRNAISKSIGQAKAKGEDVAPIMAQVGSLGE
ELDAKKTELAALLEELNAIAMSVPNLPDESVPTGADESENVEVRRWGTPKEFDFAVKDHVELGENIGGLDFKNAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTTEHGYTEAYVPLLVNEDSLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDTIVEEDNLPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQLVKPEDSMQALEDLTGHAEVVLQKLGLP
YRTMVLCTGDMGFGSAKTYDIEVWLPAQDTYREISSCSNMQDFQARRMQARYKGKTDKKPSLLHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEALRGYMGGLKKIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=464, Percent_Identity=31.8965517241379, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI225579074, Length=403, Percent_Identity=30.0248138957816, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI8923421, Length=402, Percent_Identity=30.0995024875622, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=71.8604651162791, Blast_Score=651, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=436, Percent_Identity=30.9633027522936, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=30.3030303030303, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=31.4070351758794, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=406, Percent_Identity=30.0492610837438, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24581334, Length=432, Percent_Identity=32.8703703703704, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17737985, Length=353, Percent_Identity=33.4277620396601, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47190; Mature: 47190

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPKFLRSELEMTAERLATRGFILDVERLSKLEETRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGEDVAPIMAQVGSLGEELDAKKTELAALLEELNAIAMSVPNLPDESVPTGADESEN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGTPKEFDFAVKDHVELGENIGGLDFKNAVKITGSRFIVMKGQIARMHRALAQFM
EEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEDSLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDTIVEEDNLPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQLVKPEDSM
HHHHHHHHHCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCHHH
QALEDLTGHAEVVLQKLGLPYRTMVLCTGDMGFGSAKTYDIEVWLPAQDTYREISSCSNM
HHHHHHCCHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHCCH
QDFQARRMQARYKGKTDKKPSLLHTLNGSGLAVGRTLVAVLENYQNADGSITVPEALRGY
HHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLKKIG
HHHHHHCC
>Mature Secondary Structure
MLDPKFLRSELEMTAERLATRGFILDVERLSKLEETRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGEDVAPIMAQVGSLGEELDAKKTELAALLEELNAIAMSVPNLPDESVPTGADESEN
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGTPKEFDFAVKDHVELGENIGGLDFKNAVKITGSRFIVMKGQIARMHRALAQFM
EEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEDSLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDTIVEEDNLPIKLTAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQLVKPEDSM
HHHHHHHHHCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCCCHHH
QALEDLTGHAEVVLQKLGLPYRTMVLCTGDMGFGSAKTYDIEVWLPAQDTYREISSCSNM
HHHHHHCCHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHCCH
QDFQARRMQARYKGKTDKKPSLLHTLNGSGLAVGRTLVAVLENYQNADGSITVPEALRGY
HHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLKKIG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA