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The map label for this gene is etfA [H]

Identifier: 157961955

GI number: 157961955

Start: 2585697

End: 2586650

Strand: Direct

Name: etfA [H]

Synonym: Spea_2134

Alternate gene names: 157961955

Gene position: 2585697-2586650 (Clockwise)

Preceding gene: 157961954

Following gene: 157961956

Centisome position: 49.97

GC content: 46.33

Gene sequence:

>954_bases
ATGAAATTGTTAGTTATAGCTGAACACGATAATACTCGAATAGCCGACGTAACATTTAATGCGATACAAGCCGCGGCGCA
ACTCGCATCGTTCTCAACAGATGCGAAAATTGAGTTACTCATTGCTGGAGATGATTGCCAAGCTGTCGCCAACGAGGCCG
TTACTTTAAGTCATGTGGATACAGTACGTTGTGTTGAAGCCGCTCACTATCAAGCAGGCTTAGCGGAAAACTTAGCGAGT
TTGGTTGTTGAGCAGACTGAAAAACATCAGTATCAAGCCATTATTGCAGCAAGCAGTAGTTTTGGTAAGAATGTGGCTCC
CCGCATCGCGGCATTATTGGATGTTTCACAGATATCTGATGTAACCGCCATCAATGGTCTAGGCCGATATACAAGACCAA
TCTATGCCGGCAACATCATGCTCAACTGTGAGACGCAAGATCCTGTACAGGTGCTAACGATTAGACCGACAGCTTTTGAT
AAGGTCACTAACCAAGGCCAAGCCGAATGTATTAGTGAGTCTCCAGCACAAGATCTCGGTTTATCTCGGCTGATTAAACG
TGAATTGTCTGAGTCAGACAGACCCGAACTTGGCGCGGCTAACATTATTATTTCAGGAGGGCGTGGCCTAGGAAGTGGCG
ATAATTACAAACAACTACTCGAACCTCTGGCTGATAAACTTGGGGCGGCTTTGGGGGCCTCTCGAGCTGCAGTTGATGCC
GGTTACGTACCTAACGACTATCAAGTCGGACAAACCGGTAAGATTGTTGCGCCGGAACTCTATATTGCGGTTGGGATCTC
CGGGGCAATACAACACCTTGCAGGTATGAGTGACTCGCAAATCATTGTTGCCATCAATAAAGATCCAGACGCACCTATAT
TTCAAGTCGCCGACTATGGCTTAGTTGGAGATTTATTTACTGCCATTCCAGAATTAACCGGAGCACTAACGTAA

Upstream 100 bases:

>100_bases
GTTCCCGGCGACACGCAGTGCAGGTGTTATGGTGGAAGACGTTGCAGAGTTAGTGAGTAAATTACGTGAAGAAGCACGAG
TACTATAAGGAGATAGTTAA

Downstream 100 bases:

>100_bases
GTTTAATGTTTTTCGTATAGGCTGGTAGTACAGCCTATACGCAACCAATTTAAAAATAACAAAAATTATAAAGTTAATTG
GAGGGGATTTTGCCTAATAT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKLLVIAEHDNTRIADVTFNAIQAAAQLASFSTDAKIELLIAGDDCQAVANEAVTLSHVDTVRCVEAAHYQAGLAENLAS
LVVEQTEKHQYQAIIAASSSFGKNVAPRIAALLDVSQISDVTAINGLGRYTRPIYAGNIMLNCETQDPVQVLTIRPTAFD
KVTNQGQAECISESPAQDLGLSRLIKRELSESDRPELGAANIIISGGRGLGSGDNYKQLLEPLADKLGAALGASRAAVDA
GYVPNDYQVGQTGKIVAPELYIAVGISGAIQHLAGMSDSQIIVAINKDPDAPIFQVADYGLVGDLFTAIPELTGALT

Sequences:

>Translated_317_residues
MKLLVIAEHDNTRIADVTFNAIQAAAQLASFSTDAKIELLIAGDDCQAVANEAVTLSHVDTVRCVEAAHYQAGLAENLAS
LVVEQTEKHQYQAIIAASSSFGKNVAPRIAALLDVSQISDVTAINGLGRYTRPIYAGNIMLNCETQDPVQVLTIRPTAFD
KVTNQGQAECISESPAQDLGLSRLIKRELSESDRPELGAANIIISGGRGLGSGDNYKQLLEPLADKLGAALGASRAAVDA
GYVPNDYQVGQTGKIVAPELYIAVGISGAIQHLAGMSDSQIIVAINKDPDAPIFQVADYGLVGDLFTAIPELTGALT
>Mature_317_residues
MKLLVIAEHDNTRIADVTFNAIQAAAQLASFSTDAKIELLIAGDDCQAVANEAVTLSHVDTVRCVEAAHYQAGLAENLAS
LVVEQTEKHQYQAIIAASSSFGKNVAPRIAALLDVSQISDVTAINGLGRYTRPIYAGNIMLNCETQDPVQVLTIRPTAFD
KVTNQGQAECISESPAQDLGLSRLIKRELSESDRPELGAANIIISGGRGLGSGDNYKQLLEPLADKLGAALGASRAAVDA
GYVPNDYQVGQTGKIVAPELYIAVGISGAIQHLAGMSDSQIIVAINKDPDAPIFQVADYGLVGDLFTAIPELTGALT

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=311, Percent_Identity=50.8038585209003, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI189181759, Length=268, Percent_Identity=52.6119402985075, Blast_Score=274, Evalue=7e-74,
Organism=Escherichia coli, GI1787990, Length=252, Percent_Identity=30.952380952381, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786226, Length=252, Percent_Identity=32.5396825396825, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87082157, Length=251, Percent_Identity=31.0756972111554, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17506929, Length=315, Percent_Identity=51.7460317460318, Blast_Score=320, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6325261, Length=288, Percent_Identity=43.75, Blast_Score=236, Evalue=3e-63,
Organism=Drosophila melanogaster, GI17136898, Length=318, Percent_Identity=53.7735849056604, Blast_Score=318, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24652801, Length=318, Percent_Identity=53.7735849056604, Blast_Score=318, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 33326; Mature: 33326

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVIAEHDNTRIADVTFNAIQAAAQLASFSTDAKIELLIAGDDCQAVANEAVTLSHVD
CEEEEEEECCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCEEEEHHH
TVRCVEAAHYQAGLAENLASLVVEQTEKHQYQAIIAASSSFGKNVAPRIAALLDVSQISD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
VTAINGLGRYTRPIYAGNIMLNCETQDPVQVLTIRPTAFDKVTNQGQAECISESPAQDLG
HHHHHCCCCCCCCEEECEEEEEECCCCCEEEEEECCHHHHHHCCCCHHHHHCCCCHHHHH
LSRLIKRELSESDRPELGAANIIISGGRGLGSGDNYKQLLEPLADKLGAALGASRAAVDA
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCC
GYVPNDYQVGQTGKIVAPELYIAVGISGAIQHLAGMSDSQIIVAINKDPDAPIFQVADYG
CCCCCCCEECCCCCEECCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEHHCCC
LVGDLFTAIPELTGALT
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLLVIAEHDNTRIADVTFNAIQAAAQLASFSTDAKIELLIAGDDCQAVANEAVTLSHVD
CEEEEEEECCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCEEEEHHH
TVRCVEAAHYQAGLAENLASLVVEQTEKHQYQAIIAASSSFGKNVAPRIAALLDVSQISD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
VTAINGLGRYTRPIYAGNIMLNCETQDPVQVLTIRPTAFDKVTNQGQAECISESPAQDLG
HHHHHCCCCCCCCEEECEEEEEECCCCCEEEEEECCHHHHHHCCCCHHHHHCCCCHHHHH
LSRLIKRELSESDRPELGAANIIISGGRGLGSGDNYKQLLEPLADKLGAALGASRAAVDA
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCC
GYVPNDYQVGQTGKIVAPELYIAVGISGAIQHLAGMSDSQIIVAINKDPDAPIFQVADYG
CCCCCCCEECCCCCEECCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEHHCCC
LVGDLFTAIPELTGALT
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8599534; 12597275 [H]