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The map label for this gene is uraA [H]

Identifier: 157961788

GI number: 157961788

Start: 2390178

End: 2391434

Strand: Reverse

Name: uraA [H]

Synonym: Spea_1965

Alternate gene names: 157961788

Gene position: 2391434-2390178 (Counterclockwise)

Preceding gene: 157961791

Following gene: 157961786

Centisome position: 46.22

GC content: 45.35

Gene sequence:

>1257_bases
ATGAAAAACCTAACAATGCCTTTGCAGGGAGCGCAAATGCTGTTTGTCGCCTTTGGTTCCTTAGTATTGATGCCTTTACT
GACAGGCTTAGATACCAACGTTGCACTATTTACCGCTGGCATAGGTACCCTAATATTCCAATTGATCACTAAACGTCAAA
TCCCAATCTTTTTAGCGTCCTCTTTCGCTTTCATCGCGCCGATTATGTACGGCGTACAAACTTGGGGAATTCCATCTACC
ATGGGTGGCTTAATGGCTGCTGGTATTGTTTATGTAATTTTAGCTTCAGTAGTTAAAGTCAGAGGTGGTGGATTCATAAA
GCGCTTACTGCCTCCAGTTGTCGTAGGCCCCGTCATTATTGTTATTGGTTTAGGCTTAGCGCCTGTCGCCGTTAACATGG
CAGTCGGCAAGAGTGGCGATGGTGGCCTGGTTCTTGTTGAACAAAATGTGGCACTCTTTATATCACTAGCCTCACTTTTC
ACTACTATAGCCGTAGCCATTTTCGCTAAAGGAATACTGAGGTTGATGCCAATTCTTGCTGGTATTTCTGTCGGTTACGG
ATTAAGTCTCGCGTATGGTATTGTTGACTTTACCCCAGTAAGAGACGCGGCTTGGTTGGCGATGCCAAACTTCGTAGCTC
CAGAGTTTAACTGGCATGCCATTCTATTTATGATCCCTGTCGCAATAGCACCGGCAGTCGAGCACATTGGCGATATTCTC
GCTATCTCTAACGTAACAGGAAAAGATTATCTTAAAAAACCAGGATTACACCGCACTCTAGCGGGTGACGGCGTTGCGAC
GATTGCAGCTTCAGCGTTCGGTGGACCACCTAATACAACGTATAGTGAAGTCACCGGAGCCGTCACTCTGACCAAGAACT
TTAACCCTGTAGTCATGACTTGGACGGCGATTACAGCCATCCTATTCTCTTTCGTTGGTAAGCTTGGCGCGCTACTACAA
ACCATTCCTGTACCTGTTATGGGGGGTATCATGTGCCTACTGTTTGGTTCGATTGCAGCTGTAGGTCTTAATTCTTTAAT
TAAGAACAATGTTGACATGAATGAGCCACGAAACTTAAGTATTGTGGGTGTCACATTGGTATTCGGTATCGGTGGAATGG
CATTCGGTATCGGTTCATTCAGTCTAACGGGTATTAGCCTATGCGGTATCCTAGCGATCGTAATGAACCTGTTGCTACCT
GACAACGCCGCGTCACATGAAAAGATTATCAGTGAGAAAGTTAATCCTCCTTCATAA

Upstream 100 bases:

>100_bases
GGCCCGGCAAAACCACTTGACATATTTTTGAAGCAACTCACACACCCACACACCTAAACCAGTTAGTATTGATAGGTTTA
CTTAAAATAAGAGATAGATA

Downstream 100 bases:

>100_bases
TTAAGTCCTAAATATAGGACACATTTCTGGACGAGATATACCTAAAAAAAGCCCCTATTGGTAAACCAATAGGGGCTTTT
TATTCGCTAAAACTTTTACA

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKNLTMPLQGAQMLFVAFGSLVLMPLLTGLDTNVALFTAGIGTLIFQLITKRQIPIFLASSFAFIAPIMYGVQTWGIPST
MGGLMAAGIVYVILASVVKVRGGGFIKRLLPPVVVGPVIIVIGLGLAPVAVNMAVGKSGDGGLVLVEQNVALFISLASLF
TTIAVAIFAKGILRLMPILAGISVGYGLSLAYGIVDFTPVRDAAWLAMPNFVAPEFNWHAILFMIPVAIAPAVEHIGDIL
AISNVTGKDYLKKPGLHRTLAGDGVATIAASAFGGPPNTTYSEVTGAVTLTKNFNPVVMTWTAITAILFSFVGKLGALLQ
TIPVPVMGGIMCLLFGSIAAVGLNSLIKNNVDMNEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGILAIVMNLLLP
DNAASHEKIISEKVNPPS

Sequences:

>Translated_418_residues
MKNLTMPLQGAQMLFVAFGSLVLMPLLTGLDTNVALFTAGIGTLIFQLITKRQIPIFLASSFAFIAPIMYGVQTWGIPST
MGGLMAAGIVYVILASVVKVRGGGFIKRLLPPVVVGPVIIVIGLGLAPVAVNMAVGKSGDGGLVLVEQNVALFISLASLF
TTIAVAIFAKGILRLMPILAGISVGYGLSLAYGIVDFTPVRDAAWLAMPNFVAPEFNWHAILFMIPVAIAPAVEHIGDIL
AISNVTGKDYLKKPGLHRTLAGDGVATIAASAFGGPPNTTYSEVTGAVTLTKNFNPVVMTWTAITAILFSFVGKLGALLQ
TIPVPVMGGIMCLLFGSIAAVGLNSLIKNNVDMNEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGILAIVMNLLLP
DNAASHEKIISEKVNPPS
>Mature_418_residues
MKNLTMPLQGAQMLFVAFGSLVLMPLLTGLDTNVALFTAGIGTLIFQLITKRQIPIFLASSFAFIAPIMYGVQTWGIPST
MGGLMAAGIVYVILASVVKVRGGGFIKRLLPPVVVGPVIIVIGLGLAPVAVNMAVGKSGDGGLVLVEQNVALFISLASLF
TTIAVAIFAKGILRLMPILAGISVGYGLSLAYGIVDFTPVRDAAWLAMPNFVAPEFNWHAILFMIPVAIAPAVEHIGDIL
AISNVTGKDYLKKPGLHRTLAGDGVATIAASAFGGPPNTTYSEVTGAVTLTKNFNPVVMTWTAITAILFSFVGKLGALLQ
TIPVPVMGGIMCLLFGSIAAVGLNSLIKNNVDMNEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGILAIVMNLLLP
DNAASHEKIISEKVNPPS

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=432, Percent_Identity=26.1574074074074, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI44680143, Length=436, Percent_Identity=25.9174311926606, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI44680148, Length=390, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI40316845, Length=390, Percent_Identity=25.6410256410256, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1788843, Length=394, Percent_Identity=39.5939086294416, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87081818, Length=411, Percent_Identity=36.4963503649635, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082181, Length=435, Percent_Identity=28.5057471264368, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI87082178, Length=318, Percent_Identity=27.6729559748428, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790087, Length=372, Percent_Identity=25.5376344086022, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=217, Percent_Identity=26.7281105990783, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=418, Percent_Identity=22.9665071770335, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356175, Length=312, Percent_Identity=28.525641025641, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 43445; Mature: 43445

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTMPLQGAQMLFVAFGSLVLMPLLTGLDTNVALFTAGIGTLIFQLITKRQIPIFLAS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
SFAFIAPIMYGVQTWGIPSTMGGLMAAGIVYVILASVVKVRGGGFIKRLLPPVVVGPVII
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
VIGLGLAPVAVNMAVGKSGDGGLVLVEQNVALFISLASLFTTIAVAIFAKGILRLMPILA
HHHCCHHHHHEEHEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GISVGYGLSLAYGIVDFTPVRDAAWLAMPNFVAPEFNWHAILFMIPVAIAPAVEHIGDIL
HHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AISNVTGKDYLKKPGLHRTLAGDGVATIAASAFGGPPNTTYSEVTGAVTLTKNFNPVVMT
HCCCCCCHHHHHCCCCCEECCCCCHHHHHHHHCCCCCCCCHHHHCCEEEEECCCCCEEEH
WTAITAILFSFVGKLGALLQTIPVPVMGGIMCLLFGSIAAVGLNSLIKNNVDMNEPRNLS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
IVGVTLVFGIGGMAFGIGSFSLTGISLCGILAIVMNLLLPDNAASHEKIISEKVNPPS
EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKNLTMPLQGAQMLFVAFGSLVLMPLLTGLDTNVALFTAGIGTLIFQLITKRQIPIFLAS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHH
SFAFIAPIMYGVQTWGIPSTMGGLMAAGIVYVILASVVKVRGGGFIKRLLPPVVVGPVII
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHH
VIGLGLAPVAVNMAVGKSGDGGLVLVEQNVALFISLASLFTTIAVAIFAKGILRLMPILA
HHHCCHHHHHEEHEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GISVGYGLSLAYGIVDFTPVRDAAWLAMPNFVAPEFNWHAILFMIPVAIAPAVEHIGDIL
HHHHCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AISNVTGKDYLKKPGLHRTLAGDGVATIAASAFGGPPNTTYSEVTGAVTLTKNFNPVVMT
HCCCCCCHHHHHCCCCCEECCCCCHHHHHHHHCCCCCCCCHHHHCCEEEEECCCCCEEEH
WTAITAILFSFVGKLGALLQTIPVPVMGGIMCLLFGSIAAVGLNSLIKNNVDMNEPRNLS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
IVGVTLVFGIGGMAFGIGSFSLTGISLCGILAIVMNLLLPDNAASHEKIISEKVNPPS
EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]