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The map label for this gene is phoP [H]

Identifier: 157961570

GI number: 157961570

Start: 2123470

End: 2124144

Strand: Reverse

Name: phoP [H]

Synonym: Spea_1746

Alternate gene names: 157961570

Gene position: 2124144-2123470 (Counterclockwise)

Preceding gene: 157961574

Following gene: 157961569

Centisome position: 41.05

GC content: 46.22

Gene sequence:

>675_bases
ATGCGAATATTAGTTGTTGAAGATGACCCGATTCTATCTCACCACCTAAAAGTGCAACTCAGCGAATTAGGCAATCAAGT
TCAAGTTGCGCTAACAGCGAAAGAGGGATTTTATCAAGCCACTAACTATCCTATCGATGTGGCTATCGTCGACTTAGGCC
TTCCAGACCAAGACGGTATAAGCCTAATTCAAAGTCTTCGTGACGAGGGTTTAAAAGCCCCGGTATTGATCTTAACCGCT
CGGGTTAATTGGCAAGATAAGGTAGAAGGACTGAATGCTGGCGCCGATGACTACCTAGTTAAACCTTTCCAGAAAGAAGA
GTTAGTCGCTCGCTTAGATGCCCTCGTGCGTCGTAGTGCTGGCTTTGTAAAACCCCAAATCACCAGCGGTGCACTTGAGC
TTGATCTTGCAGCCAAGCAAGTCAGCCTCAACGAGCAACCTATGGAAGTGACAGCATTTGAATATTTGATTCTTGAGTAC
CTGATGCGACACTGCCATGAGGTAGTGGCTAAACAGCGCCTGCTGGATGTGATCTATGGCGATAAGGAAGGTGACCCCAA
TACTATCGAAGTCATGGTCAGCCGCCTACGTAAGAAACTCACCAAAGGCGGTATCGAAAACCCTATTGTAACCATTCGAG
GCCAAGGGTATAAATTCAATCTGCCATGCAATTAA

Upstream 100 bases:

>100_bases
GTTTCTTGAGCGTAAACTTCCTCTATTTAGAAACACTTAGTTGGCAGGAGTGTTAATTCTGCGTAAACTAATCTGTATTG
AATTCAAGGATATTGTGACT

Downstream 100 bases:

>100_bases
AATTTAAGCCTAAGAAGCGTCTGCTAACGCGGATGTTTCTCACCTCTTTATCCATTATTGCTCTCGTAGGCTTTGGCTTA
GCGTGGATGGTTAATATTCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRILVVEDDPILSHHLKVQLSELGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGISLIQSLRDEGLKAPVLILTA
RVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPQITSGALELDLAAKQVSLNEQPMEVTAFEYLILEY
LMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTKGGIENPIVTIRGQGYKFNLPCN

Sequences:

>Translated_224_residues
MRILVVEDDPILSHHLKVQLSELGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGISLIQSLRDEGLKAPVLILTA
RVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPQITSGALELDLAAKQVSLNEQPMEVTAFEYLILEY
LMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTKGGIENPIVTIRGQGYKFNLPCN
>Mature_224_residues
MRILVVEDDPILSHHLKVQLSELGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGISLIQSLRDEGLKAPVLILTA
RVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPQITSGALELDLAAKQVSLNEQPMEVTAFEYLILEY
LMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTKGGIENPIVTIRGQGYKFNLPCN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=48.1981981981982, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.10407239819, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=39.0909090909091, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=34.375, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=35.8744394618834, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=34.5454545454545, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=34.2105263157895, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=32.034632034632, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.4801762114537, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=27.6785714285714, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=28.2511210762332, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=29.1304347826087, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=36.2745098039216, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24989; Mature: 24989

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDDPILSHHLKVQLSELGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGI
CEEEEECCCCCHHHHHEEEHHHCCCEEEEEEEECCCCEECCCCCEEEEEEEECCCCCHHH
SLIQSLRDEGLKAPVLILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSA
HHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHC
GFVKPQITSGALELDLAAKQVSLNEQPMEVTAFEYLILEYLMRHCHEVVAKQRLLDVIYG
CCCCCCCCCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DKEGDPNTIEVMVSRLRKKLTKGGIENPIVTIRGQGYKFNLPCN
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
>Mature Secondary Structure
MRILVVEDDPILSHHLKVQLSELGNQVQVALTAKEGFYQATNYPIDVAIVDLGLPDQDGI
CEEEEECCCCCHHHHHEEEHHHCCCEEEEEEEECCCCEECCCCCEEEEEEEECCCCCHHH
SLIQSLRDEGLKAPVLILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSA
HHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHC
GFVKPQITSGALELDLAAKQVSLNEQPMEVTAFEYLILEYLMRHCHEVVAKQRLLDVIYG
CCCCCCCCCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DKEGDPNTIEVMVSRLRKKLTKGGIENPIVTIRGQGYKFNLPCN
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA