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The map label for this gene is phoQ [H]

Identifier: 157961569

GI number: 157961569

Start: 2122127

End: 2123479

Strand: Reverse

Name: phoQ [H]

Synonym: Spea_1745

Alternate gene names: 157961569

Gene position: 2123479-2122127 (Counterclockwise)

Preceding gene: 157961570

Following gene: 157961558

Centisome position: 41.04

GC content: 45.31

Gene sequence:

>1353_bases
ATGCAATTAAAATTTAAGCCTAAGAAGCGTCTGCTAACGCGGATGTTTCTCACCTCTTTATCCATTATTGCTCTCGTAGG
CTTTGGCTTAGCGTGGATGGTTAATATTCTCCACGCCCAAAATAGCTATAACGAAGAGACAGCTGAACTTATCTCTGAGA
TCCCAAAAGTAGCAGCCGAGCTTAGGGAACACGATCTTATTCCCGACACCAGTGATGAATGGCTAGAAGAGAATAATGCC
GCCCAGCGTTATATCATCGCCAGCTGTGATAACACCTTTAATCAAGTCTGGACCTCATCCTTAGCGGTAGACCGTGGTTT
ATTCGACACCTGCGAACGCTTTAACGAGATAAGAAATAGCTCTCCTCCTTACTACCTGTCACTGGCGGACAACAAAGGCT
ACTTCATCTATCTGTTATCGTTAGATATCGCCAGTAATAAGTACAATCTACTGGTATTGAAAGATGCTGAGAAACTCGAA
GAAGAATACAGTAAGTTCAGTCGCCTAACCTATATACGTTTAGCCTTCGTTCTAGCCTTGGCTCTAGTGCTTTTAATCAG
TGCCGCCTATTGGGGAATGAGACCCTTGGTACGACTTAAAAACGAACTCCAATCGGTCAACAATGGTAAAGCCAAATCAC
TTTCTGATGGCTACCCAGTTGAGCTAGAAGGGGTGACTCAGGCACTCAACCAACTACTGAATCAATCCAGTGCTCAGCAG
CAACGCTATCAAAACGCAATGAATGATTTGGCTCACAGCCTTAAAACACGCCTAGCGGCGGTACATGCGATTACCGATGA
CAGAACGCTTGATAAAGATGCCTGCAGCGAGAAAATCATGGAGCAAGTAAGCCAGATGGATCAATTGGTGAAATACCAAT
TGAAGCGCGCCATGTTAGGCCGTAAAGGTCTAAAGCAGGAGCAAACCCAAATTGCACCTTTGGTCGATCAACTGGCGCAG
ATGTTATTCAAAGTTTATCGTGACAAACAAGTTCAATTTGAAGCCGTGATCCCTAAAGAGCATGTGTTCCCGGGTGATAA
AGGCGACTTGATGGAACTTTGCGGCAACTTGATGGAAAATGCCTTTAAGCTGTGTATTTCAACAGTCAGAGTGTCGTCAT
ACTATAACGATGCCGGAGAGTTTGAACTTCTAGTTGAAGATGATGGTCCGGGTGTAGAAGAAAGCATTCGCCAAAACATC
ATTGAGCGAGGTGTACGCGCCGACACTCAAAAAGCCGGTCAGGGCATTGGCCTCGCGGTCTGTAATGAGATTGTCATCAG
TTATGGCGGACGACTCAGTATCGAAACTTCCGAGCTTGAAGGCGCCTGCTTTAGGATCTCCATTCCGATTTAA

Upstream 100 bases:

>100_bases
TCGAAGTCATGGTCAGCCGCCTACGTAAGAAACTCACCAAAGGCGGTATCGAAAACCCTATTGTAACCATTCGAGGCCAA
GGGTATAAATTCAATCTGCC

Downstream 100 bases:

>100_bases
ATCGGACTCGAGTCTCAGCATTCACTTAACACACGGGGATAACATCGGCACTGAATGCGTGTTCTCCCTGCTTCAATTGC
CTTAATATTATTTAGCAGCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MQLKFKPKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAELISEIPKVAAELREHDLIPDTSDEWLEENNA
AQRYIIASCDNTFNQVWTSSLAVDRGLFDTCERFNEIRNSSPPYYLSLADNKGYFIYLLSLDIASNKYNLLVLKDAEKLE
EEYSKFSRLTYIRLAFVLALALVLLISAAYWGMRPLVRLKNELQSVNNGKAKSLSDGYPVELEGVTQALNQLLNQSSAQQ
QRYQNAMNDLAHSLKTRLAAVHAITDDRTLDKDACSEKIMEQVSQMDQLVKYQLKRAMLGRKGLKQEQTQIAPLVDQLAQ
MLFKVYRDKQVQFEAVIPKEHVFPGDKGDLMELCGNLMENAFKLCISTVRVSSYYNDAGEFELLVEDDGPGVEESIRQNI
IERGVRADTQKAGQGIGLAVCNEIVISYGGRLSIETSELEGACFRISIPI

Sequences:

>Translated_450_residues
MQLKFKPKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAELISEIPKVAAELREHDLIPDTSDEWLEENNA
AQRYIIASCDNTFNQVWTSSLAVDRGLFDTCERFNEIRNSSPPYYLSLADNKGYFIYLLSLDIASNKYNLLVLKDAEKLE
EEYSKFSRLTYIRLAFVLALALVLLISAAYWGMRPLVRLKNELQSVNNGKAKSLSDGYPVELEGVTQALNQLLNQSSAQQ
QRYQNAMNDLAHSLKTRLAAVHAITDDRTLDKDACSEKIMEQVSQMDQLVKYQLKRAMLGRKGLKQEQTQIAPLVDQLAQ
MLFKVYRDKQVQFEAVIPKEHVFPGDKGDLMELCGNLMENAFKLCISTVRVSSYYNDAGEFELLVEDDGPGVEESIRQNI
IERGVRADTQKAGQGIGLAVCNEIVISYGGRLSIETSELEGACFRISIPI
>Mature_450_residues
MQLKFKPKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAELISEIPKVAAELREHDLIPDTSDEWLEENNA
AQRYIIASCDNTFNQVWTSSLAVDRGLFDTCERFNEIRNSSPPYYLSLADNKGYFIYLLSLDIASNKYNLLVLKDAEKLE
EEYSKFSRLTYIRLAFVLALALVLLISAAYWGMRPLVRLKNELQSVNNGKAKSLSDGYPVELEGVTQALNQLLNQSSAQQ
QRYQNAMNDLAHSLKTRLAAVHAITDDRTLDKDACSEKIMEQVSQMDQLVKYQLKRAMLGRKGLKQEQTQIAPLVDQLAQ
MLFKVYRDKQVQFEAVIPKEHVFPGDKGDLMELCGNLMENAFKLCISTVRVSSYYNDAGEFELLVEDDGPGVEESIRQNI
IERGVRADTQKAGQGIGLAVCNEIVISYGGRLSIETSELEGACFRISIPI

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=293, Percent_Identity=35.1535836177474, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787894, Length=290, Percent_Identity=27.2413793103448, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=25.2066115702479, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=25.9124087591241, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=28.4552845528455, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=283, Percent_Identity=22.6148409893993, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50792; Mature: 50792

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKFKPKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAELISEIPKVAAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LREHDLIPDTSDEWLEENNAAQRYIIASCDNTFNQVWTSSLAVDRGLFDTCERFNEIRNS
HHHCCCCCCCCHHHHHCCCCHHEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
SPPYYLSLADNKGYFIYLLSLDIASNKYNLLVLKDAEKLEEEYSKFSRLTYIRLAFVLAL
CCCEEEEEECCCCEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ALVLLISAAYWGMRPLVRLKNELQSVNNGKAKSLSDGYPVELEGVTQALNQLLNQSSAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCHHHH
QRYQNAMNDLAHSLKTRLAAVHAITDDRTLDKDACSEKIMEQVSQMDQLVKYQLKRAMLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKGLKQEQTQIAPLVDQLAQMLFKVYRDKQVQFEAVIPKEHVFPGDKGDLMELCGNLMEN
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHH
AFKLCISTVRVSSYYNDAGEFELLVEDDGPGVEESIRQNIIERGVRADTQKAGQGIGLAV
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHCCCCHHHH
CNEIVISYGGRLSIETSELEGACFRISIPI
HHHHHHHCCCEEEEECCCCCCEEEEEECCC
>Mature Secondary Structure
MQLKFKPKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAELISEIPKVAAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LREHDLIPDTSDEWLEENNAAQRYIIASCDNTFNQVWTSSLAVDRGLFDTCERFNEIRNS
HHHCCCCCCCCHHHHHCCCCHHEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
SPPYYLSLADNKGYFIYLLSLDIASNKYNLLVLKDAEKLEEEYSKFSRLTYIRLAFVLAL
CCCEEEEEECCCCEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ALVLLISAAYWGMRPLVRLKNELQSVNNGKAKSLSDGYPVELEGVTQALNQLLNQSSAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCHHHH
QRYQNAMNDLAHSLKTRLAAVHAITDDRTLDKDACSEKIMEQVSQMDQLVKYQLKRAMLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKGLKQEQTQIAPLVDQLAQMLFKVYRDKQVQFEAVIPKEHVFPGDKGDLMELCGNLMEN
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHH
AFKLCISTVRVSSYYNDAGEFELLVEDDGPGVEESIRQNIIERGVRADTQKAGQGIGLAV
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHCCCCHHHH
CNEIVISYGGRLSIETSELEGACFRISIPI
HHHHHHHCCCEEEEECCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA