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The map label for this gene is folX [H]

Identifier: 157961489

GI number: 157961489

Start: 2016548

End: 2016919

Strand: Reverse

Name: folX [H]

Synonym: Spea_1664

Alternate gene names: 157961489

Gene position: 2016919-2016548 (Counterclockwise)

Preceding gene: 157961492

Following gene: 157961488

Centisome position: 38.98

GC content: 40.86

Gene sequence:

>372_bases
ATGAAACCAGAAATCGCCGTGATCCGTATAAAAAACCTAAGGCTACGCACCTACATTGGGATCAAAGAAGACGAAATACA
AAATAAGCAAGATGTCACCATAAATACTGTTATTCATTACTGTGCAGATAAGGCCAGAAACAGTGACAATATGGATGATG
CTCTGAATTATCGCACGATTACGAAAAAGATCATTGCTTTAGTTGAAAACAACCGCTTTTCTTTACTTGAAAACCTGACA
GGCCAAGTATTGGAGATCGCAAGTGAACATCCGTGGGTTGATTTTGCCAAGGTCGAAATTGACAAGCCATACGCGCTGCG
GTTTGCAGATTCTGTCTCACTAGAGCTGTGCTATCAAAAAGCACCGCTTTAA

Upstream 100 bases:

>100_bases
AATCGTCTCATTACAATAAAATCCTTCTTGATTCACTATAATATTGATAGGGTTATATAAACTGCTTCTAACATACACTG
CAATAGGGACATCGTTTTAT

Downstream 100 bases:

>100_bases
CAGTCACAATCTAGCGTGCTGACAGCAAGACCTTTAACTTACATTGTATCTATTTGAGCCTATGAATATATTAATGACTG
GCGCCAGTGGATTTATCGGT

Product: D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase

Products: L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

Alternate protein names: Dihydroneopterin triphosphate 2'-epimerase [H]

Number of amino acids: Translated: 123; Mature: 123

Protein sequence:

>123_residues
MKPEIAVIRIKNLRLRTYIGIKEDEIQNKQDVTINTVIHYCADKARNSDNMDDALNYRTITKKIIALVENNRFSLLENLT
GQVLEIASEHPWVDFAKVEIDKPYALRFADSVSLELCYQKAPL

Sequences:

>Translated_123_residues
MKPEIAVIRIKNLRLRTYIGIKEDEIQNKQDVTINTVIHYCADKARNSDNMDDALNYRTITKKIIALVENNRFSLLENLT
GQVLEIASEHPWVDFAKVEIDKPYALRFADSVSLELCYQKAPL
>Mature_123_residues
MKPEIAVIRIKNLRLRTYIGIKEDEIQNKQDVTINTVIHYCADKARNSDNMDDALNYRTITKKIIALVENNRFSLLENLT
GQVLEIASEHPWVDFAKVEIDKPYALRFADSVSLELCYQKAPL

Specific function: Catalyzes the epimerization of carbon 2' of the side chain of dihydroneopterin triphosphate (H2NTP) to form dihydromonapterin triphosphate (H2MTP) [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI1788641, Length=120, Percent_Identity=66.6666666666667, Blast_Score=166, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: 5.-.-.- [C]

Molecular weight: Translated: 14195; Mature: 14195

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPEIAVIRIKNLRLRTYIGIKEDEIQNKQDVTINTVIHYCADKARNSDNMDDALNYRTI
CCCCEEEEEEECEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TKKIIALVENNRFSLLENLTGQVLEIASEHPWVDFAKVEIDKPYALRFADSVSLELCYQK
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCEEEEEEC
APL
CCC
>Mature Secondary Structure
MKPEIAVIRIKNLRLRTYIGIKEDEIQNKQDVTINTVIHYCADKARNSDNMDDALNYRTI
CCCCEEEEEEECEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TKKIIALVENNRFSLLENLTGQVLEIASEHPWVDFAKVEIDKPYALRFADSVSLELCYQK
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCEEEEEEC
APL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Erythro-7,8-Dihydroneopterin Triphosphate [C]

Specific reaction: D-Erythro-7,8-Dihydroneopterin Triphosphate = L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]