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The map label for this gene is pip [H]

Identifier: 157961460

GI number: 157961460

Start: 1979104

End: 1980405

Strand: Reverse

Name: pip [H]

Synonym: Spea_1634

Alternate gene names: 157961460

Gene position: 1980405-1979104 (Counterclockwise)

Preceding gene: 157961464

Following gene: 157961459

Centisome position: 38.27

GC content: 46.08

Gene sequence:

>1302_bases
ATGACTTCTGAATTTTCTGCATCACTTACTTTTTCTGGCATGATTGCCCGTAAACACCAATTTAGTTTACCTCTTGATTA
TCAAAATCCTGATGGCGAGCAAATTTCAATATTTGTCCGCGAGATCTCAAGCCCTGAAAATCAAGATAAAGCCCTACCTT
TTATTGTGTTCTTTCAAGGCGGCCCTGGGTTTGGAGCGGTCCGTCCTGCGGCAAACGGCGGCTGGATAAAGCGAGCCCTC
AAAGAGTACCGTGTATTGCTACTCGATCAACGCGGCACTGGACTGTCGACACCGGTGAGTTTTGCTAGTTTGGCGCACTT
ACCTGCCAGCGAGCAAGCCGAGTACCTAAGCCATTTTAGAGCCGACAATATCATTCGTGATGCAGAGACTATTCGAAAAC
AGCTCACCAATGACGAAAAGTGGACGATTCTCGGACAAAGTTTTGGTGGTTTTTGCGTACTCAAATACTTAAATGATGCA
CCCGAAGGATTAGCGGAAGCCTATATAACCGGTGGTATTCCGTCACTAACCCGCAGCGCAGATGAGGTATATCAAGCAAC
TTACAAGCGCGTACAGGCAAAAAACCAAGACTTTTTTAACCGTTTTAGCGATGCTCAGGATTTGGTTAAAGCACTAGCAA
GCCATATCCAAGACAACGAAGTTTTCCTTGCCACTGGCGAACGTCTAACGGTTGAGATGTTGCAATTGCTTGGGATCAAT
ATCGGTATGGAGCAAGGTCCTGAAAGCGTCTATTACCTACTAGAACAAGCGTTAATCGAAACGGCGACTGGGACACAAGT
TAATCCTCTTTTCTTGGCGCACTTCTGCCAACTACTCGATTTCAACACTAACCCCATATTTGCCCTGTTGCATGAATCTA
TCTATTGCCAACAATCGGCGTCTAACTGGGCGGCGCATCGCGTTAGGCAGCAGTATCCTGAATTTAATTATCAAACCGAT
AAGCCATTCCTGTTTACCGGCGAAATGGTCTATCCGTGGATGTTCGAGCAATTCAATAATCTCAAGCCGCTACAGCAAGC
AGCGAAGAAACTGGCCGAGAAACAGGACTGGCCGAACCTATATCAAGTCGACAAACTTGCCGATAATCAGGTGCCTGTTG
CCGCCGCGATATACAGTGAAGATATGTTCGTTGAGATGCAGTACAGCCTAGAAACGACGGCACAAGTCGGTAAGCTCAAA
TATTGGCTAACCTCTGAATATGAACACAACGGGATCCGCATGGATGGCGAGCATATTCTTGATAGATTAATTGCAATTAA
TCGCGGGGAAAAGCTGCGTTAA

Upstream 100 bases:

>100_bases
GTTGTTATTCGTTCGCTGTCATTGGGGCAAGTGATTGTCCGACTGATGCCGCAACCTTAAGTTGCAACCTAACAAGAACT
CCTAATAAAAGGTCGACTCT

Downstream 100 bases:

>100_bases
TTAATAAACTCTTAAGCTTAATGGGACATTATGTAATCTGTTCCTCACCTGTATCACTTTCGCAAGCCTTATCAAGGCTT
GCTTTTTTTTGCCTCAAAAT

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTSEFSASLTFSGMIARKHQFSLPLDYQNPDGEQISIFVREISSPENQDKALPFIVFFQGGPGFGAVRPAANGGWIKRAL
KEYRVLLLDQRGTGLSTPVSFASLAHLPASEQAEYLSHFRADNIIRDAETIRKQLTNDEKWTILGQSFGGFCVLKYLNDA
PEGLAEAYITGGIPSLTRSADEVYQATYKRVQAKNQDFFNRFSDAQDLVKALASHIQDNEVFLATGERLTVEMLQLLGIN
IGMEQGPESVYYLLEQALIETATGTQVNPLFLAHFCQLLDFNTNPIFALLHESIYCQQSASNWAAHRVRQQYPEFNYQTD
KPFLFTGEMVYPWMFEQFNNLKPLQQAAKKLAEKQDWPNLYQVDKLADNQVPVAAAIYSEDMFVEMQYSLETTAQVGKLK
YWLTSEYEHNGIRMDGEHILDRLIAINRGEKLR

Sequences:

>Translated_433_residues
MTSEFSASLTFSGMIARKHQFSLPLDYQNPDGEQISIFVREISSPENQDKALPFIVFFQGGPGFGAVRPAANGGWIKRAL
KEYRVLLLDQRGTGLSTPVSFASLAHLPASEQAEYLSHFRADNIIRDAETIRKQLTNDEKWTILGQSFGGFCVLKYLNDA
PEGLAEAYITGGIPSLTRSADEVYQATYKRVQAKNQDFFNRFSDAQDLVKALASHIQDNEVFLATGERLTVEMLQLLGIN
IGMEQGPESVYYLLEQALIETATGTQVNPLFLAHFCQLLDFNTNPIFALLHESIYCQQSASNWAAHRVRQQYPEFNYQTD
KPFLFTGEMVYPWMFEQFNNLKPLQQAAKKLAEKQDWPNLYQVDKLADNQVPVAAAIYSEDMFVEMQYSLETTAQVGKLK
YWLTSEYEHNGIRMDGEHILDRLIAINRGEKLR
>Mature_432_residues
TSEFSASLTFSGMIARKHQFSLPLDYQNPDGEQISIFVREISSPENQDKALPFIVFFQGGPGFGAVRPAANGGWIKRALK
EYRVLLLDQRGTGLSTPVSFASLAHLPASEQAEYLSHFRADNIIRDAETIRKQLTNDEKWTILGQSFGGFCVLKYLNDAP
EGLAEAYITGGIPSLTRSADEVYQATYKRVQAKNQDFFNRFSDAQDLVKALASHIQDNEVFLATGERLTVEMLQLLGINI
GMEQGPESVYYLLEQALIETATGTQVNPLFLAHFCQLLDFNTNPIFALLHESIYCQQSASNWAAHRVRQQYPEFNYQTDK
PFLFTGEMVYPWMFEQFNNLKPLQQAAKKLAEKQDWPNLYQVDKLADNQVPVAAAIYSEDMFVEMQYSLETTAQVGKLKY
WLTSEYEHNGIRMDGEHILDRLIAINRGEKLR

Specific function: Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 49134; Mature: 49003

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEFSASLTFSGMIARKHQFSLPLDYQNPDGEQISIFVREISSPENQDKALPFIVFFQG
CCCCCCCCEEEHHHHECCCCCCCCCCCCCCCCCEEEEEEEHHCCCCCCCCCCCEEEEEEC
GPGFGAVRPAANGGWIKRALKEYRVLLLDQRGTGLSTPVSFASLAHLPASEQAEYLSHFR
CCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
ADNIIRDAETIRKQLTNDEKWTILGQSFGGFCVLKYLNDAPEGLAEAYITGGIPSLTRSA
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHCCCCHHHHHHHHCCCCCHHHHHH
DEVYQATYKRVQAKNQDFFNRFSDAQDLVKALASHIQDNEVFLATGERLTVEMLQLLGIN
HHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCC
IGMEQGPESVYYLLEQALIETATGTQVNPLFLAHFCQLLDFNTNPIFALLHESIYCQQSA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SNWAAHRVRQQYPEFNYQTDKPFLFTGEMVYPWMFEQFNNLKPLQQAAKKLAEKQDWPNL
HHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCH
YQVDKLADNQVPVAAAIYSEDMFVEMQYSLETTAQVGKLKYWLTSEYEHNGIRMDGEHIL
HHHHHHCCCCCCEEEEEECCCEEEEEEECHHHHHHHHHEEEEEECCCCCCCEEECHHHHH
DRLIAINRGEKLR
HHHHHHCCCCCCC
>Mature Secondary Structure 
TSEFSASLTFSGMIARKHQFSLPLDYQNPDGEQISIFVREISSPENQDKALPFIVFFQG
CCCCCCCEEEHHHHECCCCCCCCCCCCCCCCCEEEEEEEHHCCCCCCCCCCCEEEEEEC
GPGFGAVRPAANGGWIKRALKEYRVLLLDQRGTGLSTPVSFASLAHLPASEQAEYLSHFR
CCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
ADNIIRDAETIRKQLTNDEKWTILGQSFGGFCVLKYLNDAPEGLAEAYITGGIPSLTRSA
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHCCCCHHHHHHHHCCCCCHHHHHH
DEVYQATYKRVQAKNQDFFNRFSDAQDLVKALASHIQDNEVFLATGERLTVEMLQLLGIN
HHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCC
IGMEQGPESVYYLLEQALIETATGTQVNPLFLAHFCQLLDFNTNPIFALLHESIYCQQSA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SNWAAHRVRQQYPEFNYQTDKPFLFTGEMVYPWMFEQFNNLKPLQQAAKKLAEKQDWPNL
HHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCH
YQVDKLADNQVPVAAAIYSEDMFVEMQYSLETTAQVGKLKYWLTSEYEHNGIRMDGEHIL
HHHHHHCCCCCCEEEEEECCCEEEEEEECHHHHHHHHHEEEEEECCCCCCCEEECHHHHH
DRLIAINRGEKLR
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883756 [H]