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The map label for this gene is gltP [H]

Identifier: 157961396

GI number: 157961396

Start: 1906487

End: 1907749

Strand: Direct

Name: gltP [H]

Synonym: Spea_1570

Alternate gene names: 157961396

Gene position: 1906487-1907749 (Clockwise)

Preceding gene: 157961391

Following gene: 157961399

Centisome position: 36.84

GC content: 45.84

Gene sequence:

>1263_bases
GTGTTGAACACAAAGAAAAAGTTTTATAAGAACATTGGATTCCAAGTGGTTGTCGCCATGGTGCTGGGTGCGCTCGTGGG
TGTGATGATGGGAGAAGATGCTTCTATCTTCGCTCCGCTAGGAACATTTTTTATCCATTTGATTAAGATGTTGGTGATCC
CGTTAGTTGCCGTTTCGATTATTGCCGGTGCTGCGAGTTTAGGTGCGGGTCCGTCGGCGGGTAAAGTCGGTATCGGTACT
ATCAGTTTCTTCATGGCAACTTCAGCATTGGCTGTGACCTTAGCACTTGTTATGGGTGAGTTTTTCCAGCCTGGTGTTGG
CATGGACTTCTCACAGCACAGTGTTGGCCTCGCTGCGGTCACTGCAGAGCAGGGCGCTTTGCCTGGTGTGGCTGATACCA
TTATTGGTATGATCCCTACTAACGTGTTTGAAGCGCTTACTGGCGGTAATATCTTACAGATCTTAGTGTTCTGTATCTTC
TTTGGTATCGCACTGACTAAAGTGAATCAAGAGGCTGCTAAGCCGATTACTTCAGCACTTAATACCATAGTTGAAGCCTT
TATTTGGATGATTAACATTGTGATGTTGATTGCTCCAATCGGCGTATTTGGTCTAATGGCAGATTCAGTGGGTACCTTCG
GCTTCCAGTCATTGACTGTTGTGTTGAACCTATTCCTAGTTTATGTCGCGGCTATCTTGATCTACGGCTTTATCTTCTTC
CCACTGATGGTTAAGTTCTTCTCAAATGTTCCGGTTGGCAAGTTCCTATCGGCAATGAAGAAGCCTCAAGCATTGGCTAT
GTCTACTGCTTCATCTATGGCGGCGTTGCCAGTTAACATCGAAGTGTGTGAGAAAGAGCTTGGCGTATCTAAGTCTACAG
CTGCATTTGTACTGCCTTTAGGTGCAACCATTAACATGAGCGGTAACGCGATCTATTACGGTCTAGTTGCGGTATTCTTC
GCTCAGATGTTCAATGTTGAGCTAGGTCTTGCGGCTTATGTAGCGATTATCTTCACCTCTACACTGGGCGCCATTGGCCA
AGCGGGTGTACCGGGTCCATCGTTCCTAGTGATTGCGGTATTAGTTGCGGCAGGTATTCCAATTGAAGGTCTACCATTAT
TGTTTGCACTTGACCGCGTGTTTGACATGATCAGAACCACGTTAAACATTACTGGCGATGCGGTTTGTGCTGTGGTTATC
GATAAATTTAACCCAGAAACAGAGATTGTAGCTGAGCCTGCTCAAGTAAAAGTTAACAGCTAA

Upstream 100 bases:

>100_bases
GTGAATCACATTAATTGCCAATTCAGCGTGATACTTTGTTACTAAATAATCAAAGGGGTATTTATGCCTCTTAATAAAAT
ATGTCTGTGATGGAGCTAGG

Downstream 100 bases:

>100_bases
CGCTTCACCTTTTACCGCTAAAAGCCCTCGATTATCTAGTGATAGTTGAGGGCTTTGTTGTATCTAGAGTTAGGGCTTTT
TGTCTTGTTTGCCTAGCACG

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLNTKKKFYKNIGFQVVVAMVLGALVGVMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSIIAGAASLGAGPSAGKVGIGT
ISFFMATSALAVTLALVMGEFFQPGVGMDFSQHSVGLAAVTAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIF
FGIALTKVNQEAAKPITSALNTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPLGATINMSGNAIYYGLVAVFF
AQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAVLVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVI
DKFNPETEIVAEPAQVKVNS

Sequences:

>Translated_420_residues
MLNTKKKFYKNIGFQVVVAMVLGALVGVMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSIIAGAASLGAGPSAGKVGIGT
ISFFMATSALAVTLALVMGEFFQPGVGMDFSQHSVGLAAVTAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIF
FGIALTKVNQEAAKPITSALNTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPLGATINMSGNAIYYGLVAVFF
AQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAVLVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVI
DKFNPETEIVAEPAQVKVNS
>Mature_420_residues
MLNTKKKFYKNIGFQVVVAMVLGALVGVMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSIIAGAASLGAGPSAGKVGIGT
ISFFMATSALAVTLALVMGEFFQPGVGMDFSQHSVGLAAVTAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIF
FGIALTKVNQEAAKPITSALNTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPLGATINMSGNAIYYGLVAVFF
AQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAVLVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVI
DKFNPETEIVAEPAQVKVNS

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=451, Percent_Identity=27.0509977827051, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI66773030, Length=477, Percent_Identity=28.3018867924528, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI21314632, Length=426, Percent_Identity=29.81220657277, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI4827012, Length=462, Percent_Identity=26.8398268398268, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI5032093, Length=407, Percent_Identity=30.2211302211302, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI40254478, Length=481, Percent_Identity=26.1954261954262, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI223468566, Length=283, Percent_Identity=31.095406360424, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI223468564, Length=277, Percent_Identity=31.4079422382672, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI194239697, Length=261, Percent_Identity=30.6513409961686, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI262359914, Length=392, Percent_Identity=27.0408163265306, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI301601644, Length=170, Percent_Identity=35.8823529411765, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=33.7349397590361, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1789947, Length=408, Percent_Identity=29.4117647058824, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789473, Length=378, Percent_Identity=27.2486772486773, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788024, Length=414, Percent_Identity=26.3285024154589, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=452, Percent_Identity=28.5398230088496, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71983106, Length=453, Percent_Identity=28.9183222958057, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI193206654, Length=416, Percent_Identity=31.0096153846154, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71996953, Length=418, Percent_Identity=28.2296650717703, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI193206505, Length=405, Percent_Identity=28.3950617283951, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=414, Percent_Identity=28.9855072463768, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=423, Percent_Identity=28.6052009456265, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583025, Length=425, Percent_Identity=24.4705882352941, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17137668, Length=425, Percent_Identity=24.4705882352941, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24583023, Length=425, Percent_Identity=24.4705882352941, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281360481, Length=477, Percent_Identity=24.7379454926625, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360483, Length=477, Percent_Identity=24.7379454926625, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137666, Length=477, Percent_Identity=24.7379454926625, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43877; Mature: 43877

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTKKKFYKNIGFQVVVAMVLGALVGVMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGAASLGAGPSAGKVGIGTISFFMATSALAVTLALVMGEFFQPGVGMDFSQHSVGLAAV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
TAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIFFGIALTKVNQEAAKPITSAL
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPL
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEC
GATINMSGNAIYYGLVAVFFAQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAV
CCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVIDKFNPETEIVAEPAQVKVNS
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHEECCCEEEECC
>Mature Secondary Structure
MLNTKKKFYKNIGFQVVVAMVLGALVGVMMGEDASIFAPLGTFFIHLIKMLVIPLVAVSI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGAASLGAGPSAGKVGIGTISFFMATSALAVTLALVMGEFFQPGVGMDFSQHSVGLAAV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
TAEQGALPGVADTIIGMIPTNVFEALTGGNILQILVFCIFFGIALTKVNQEAAKPITSAL
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NTIVEAFIWMINIVMLIAPIGVFGLMADSVGTFGFQSLTVVLNLFLVYVAAILIYGFIFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLMVKFFSNVPVGKFLSAMKKPQALAMSTASSMAALPVNIEVCEKELGVSKSTAAFVLPL
HHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEC
GATINMSGNAIYYGLVAVFFAQMFNVELGLAAYVAIIFTSTLGAIGQAGVPGPSFLVIAV
CCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LVAAGIPIEGLPLLFALDRVFDMIRTTLNITGDAVCAVVIDKFNPETEIVAEPAQVKVNS
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]