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The map label for this gene is hemH [H]

Identifier: 157961355

GI number: 157961355

Start: 1857913

End: 1858908

Strand: Direct

Name: hemH [H]

Synonym: Spea_1529

Alternate gene names: 157961355

Gene position: 1857913-1858908 (Clockwise)

Preceding gene: 157961354

Following gene: 157961356

Centisome position: 35.9

GC content: 46.79

Gene sequence:

>996_bases
GTGAGTGACTTAGCCCCGCCGTTTGGTGTGTTACTAGTAAACCTAGGTACCCCTGATTCACCTACCGCTCCAGATGTTAA
AAAATTCCTTAAGCAGTTCTTGAGCGACCCCCGAGTGGTCGACCTTTCGCCTTGGATCTGGAAGCCGATTTTGAACGGTA
TCATTCTTAATACCCGTCCAGCCAAAGTCGCTAAACTCTATCAGTCTATCTGGTGGGATGAAGGTTCACCTTTGATGGTA
ATAAGCCAAAAACAGCGCGATAAACTTAAAACGTCATTACATGAGTCACTCGGACAAGCCATTCCAGTGGAACTTGGCAT
GAGCTATGGCAATCCGTCATTGCAATCGGGGCTCGACAGCTTAAAGTCTCAAGGGGCTGAAAAGATCTTCGTTCTGCCAC
TTTACGCACAATACTCATGCTCTACCGTTGCCCCAGTTTATGATGCAATTGCACAGCTTTTAAAGTCTGAACGCAACATC
CCAGAAATGCGCATTAACAAGCAGTATTTTGATCATCCAGCCTACATTAAGGCGTTAGCTGAGTCGGTTAAGACCCATTG
GCAACTCAAAGGTCAGGCTGATGTGCTGCTGATGTCGTTTCATGGTGTGCCGCTTAGATACATTACTGAGGGCGATCCTT
ATCAGGCTCAGTGTCAATCGACTGCTGAGCTGGTGGCAAAGGAGTTGGGGTTAACACCTGAGCAGTGGCGAGTCTGCTTC
CAATCTCAGTTCGGTAAAGAGGAATGGATAAAGCCCGCTACTGATGAGTTGCTAGAGTCTTTGCCTAAACAAGGGGTTAA
GTCAGTGGATATCATGTGTCCTGCATTTTCATCCGATTGCTTAGAAACCTTGGAGGAGATCTCTCAAGAGGGCAAAGCTG
AGTTCTTATCGGCAGGGGGAGAGCGCTATGAATTTATTGATTGTCTCAACGATGCACCGGCTCACATTAAGCTATTAGCT
AAGCTGGTTGAAGAGCAAACTAGAGGCTGGTATTAA

Upstream 100 bases:

>100_bases
AGCTAGTTCTCATATTTTAAAAAGCCCATGTAAATGGGCTTTTTTTATGCTTTTTGCGGTGATAGCCTGACCTGAATATC
TTGCCAAAAAGAGAATTCAT

Downstream 100 bases:

>100_bases
ATATTCTGACTTCTATAGTGATTTCAGCTAGCGAAAGAGGTGGGGTGTGGTAAAATCCCCCACCTTTTTTGGCATCTAGC
CCTTTAAATTCACTATTTTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSDLAPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMV
ISQKQRDKLKTSLHESLGQAIPVELGMSYGNPSLQSGLDSLKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKSERNI
PEMRINKQYFDHPAYIKALAESVKTHWQLKGQADVLLMSFHGVPLRYITEGDPYQAQCQSTAELVAKELGLTPEQWRVCF
QSQFGKEEWIKPATDELLESLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGGERYEFIDCLNDAPAHIKLLA
KLVEEQTRGWY

Sequences:

>Translated_331_residues
MSDLAPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMV
ISQKQRDKLKTSLHESLGQAIPVELGMSYGNPSLQSGLDSLKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKSERNI
PEMRINKQYFDHPAYIKALAESVKTHWQLKGQADVLLMSFHGVPLRYITEGDPYQAQCQSTAELVAKELGLTPEQWRVCF
QSQFGKEEWIKPATDELLESLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGGERYEFIDCLNDAPAHIKLLA
KLVEEQTRGWY
>Mature_330_residues
SDLAPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMVI
SQKQRDKLKTSLHESLGQAIPVELGMSYGNPSLQSGLDSLKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKSERNIP
EMRINKQYFDHPAYIKALAESVKTHWQLKGQADVLLMSFHGVPLRYITEGDPYQAQCQSTAELVAKELGLTPEQWRVCFQ
SQFGKEEWIKPATDELLESLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGGERYEFIDCLNDAPAHIKLLAK
LVEEQTRGWY

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=333, Percent_Identity=27.9279279279279, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=27.9279279279279, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=49.8412698412698, Blast_Score=321, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6324750, Length=332, Percent_Identity=26.5060240963855, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17864156, Length=345, Percent_Identity=26.0869565217391, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24651774, Length=275, Percent_Identity=25.4545454545455, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45552018, Length=163, Percent_Identity=28.8343558282209, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37075; Mature: 36944

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRP
CCCCCCCHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEECCCH
AKVAKLYQSIWWDEGSPLMVISQKQRDKLKTSLHESLGQAIPVELGMSYGNPSLQSGLDS
HHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHH
LKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKSERNIPEMRINKQYFDHPAYIKALA
HHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHCCHHHHHHHH
ESVKTHWQLKGQADVLLMSFHGVPLRYITEGDPYQAQCQSTAELVAKELGLTPEQWRVCF
HHHHHHEEECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
QSQFGKEEWIKPATDELLESLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGG
HHHCCHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
ERYEFIDCLNDAPAHIKLLAKLVEEQTRGWY
CHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDLAPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRP
CCCCCCHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEECCCH
AKVAKLYQSIWWDEGSPLMVISQKQRDKLKTSLHESLGQAIPVELGMSYGNPSLQSGLDS
HHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHH
LKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKSERNIPEMRINKQYFDHPAYIKALA
HHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHCCHHHHHHHH
ESVKTHWQLKGQADVLLMSFHGVPLRYITEGDPYQAQCQSTAELVAKELGLTPEQWRVCF
HHHHHHEEECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
QSQFGKEEWIKPATDELLESLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGG
HHHCCHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
ERYEFIDCLNDAPAHIKLLAKLVEEQTRGWY
CHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]