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The map label for this gene is adk [H]

Identifier: 157961354

GI number: 157961354

Start: 1857059

End: 1857742

Strand: Direct

Name: adk [H]

Synonym: Spea_1528

Alternate gene names: 157961354

Gene position: 1857059-1857742 (Clockwise)

Preceding gene: 157961353

Following gene: 157961355

Centisome position: 35.89

GC content: 46.49

Gene sequence:

>684_bases
ATGTTGGTATCACAGTGCGAAATTAAGAGGAAGATTCAGATGCGCATTATGCTATTAGGTGCCCCAGGTGCCGGTAAAGG
TACCCAAGCCCAATTCATCATGGAAAAGTACGGTATTCCTCAAATTTCAACTGGCGACATGCTACGTGCAGCGGTTAAAG
CGGGCACACCACTAGGCTTAGAAGCTAAGAAAGTGATGGATGCTGGTCAGTTGGTTTCTGATGAGCTAATTATTGGCCTA
GTAAAAGAGCGCGTTGCACAAGATGATTGCGCTGCTGGTTTCCTATTAGACGGTTTCCCACGCACTATCCCACAAGCCGA
TGCTATGGCTTCAAGCGGTATCGCTCTTGATCACGTGATTGAAATCGATGTGCCAGACGAAGAGATCGTTAAGCGTATGA
GCGGTCGTCGTGTTCACCCAGGTTCTGGCCGTGTTTACCACATCGTTTTCAACCAGCCTAAGGTTGAAGGTAAAGATGAC
GTGACTGGTGAAGACTTAGCAATCCGTCCAGATGATGAAGAGTCTACTGTACGTAAACGTCTTGATATCTACCATGAGCA
AACTAAGCCACTAGTAGAATACTACGGCGCGGTTGCAGCTAAAGGCGATGTGACTTACAACAAGTTCGACGGTACAAAGT
CTGTAGCAAGTGTAAGCGAAGAGATTGTTACAGTACTAAGCTAA

Upstream 100 bases:

>100_bases
AATGAAAATAACTTCAAAATAGCGGCTATTTGTGCGAAGATCGCCGCCCTAAACAGAATAATACCCATCATCTAGGCGGC
TTTAGGGTCGCCCACGAGAG

Downstream 100 bases:

>100_bases
ATTAGTACTAAGCTATCTTTAAGTCGCTTGATACTTGGCTAAATAAAGCCTAAGTAACAATGTGTTTATGAGCTAGTTCT
CATATTTTAAAAAGCCCATG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MLVSQCEIKRKIQMRIMLLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGL
VKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDD
VTGEDLAIRPDDEESTVRKRLDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTKSVASVSEEIVTVLS

Sequences:

>Translated_227_residues
MLVSQCEIKRKIQMRIMLLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGL
VKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDD
VTGEDLAIRPDDEESTVRKRLDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTKSVASVSEEIVTVLS
>Mature_227_residues
MLVSQCEIKRKIQMRIMLLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGL
VKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDD
VTGEDLAIRPDDEESTVRKRLDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTKSVASVSEEIVTVLS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=50.5376344086022, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=50.5376344086022, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=44.5054945054945, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=31.1320754716981, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI22749187, Length=206, Percent_Identity=28.6407766990291, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI7706497, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI28144899, Length=187, Percent_Identity=27.807486631016, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=27.807486631016, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.8115942028986, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=69.4835680751174, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=47.3118279569892, Blast_Score=180, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=184, Percent_Identity=33.695652173913, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=34.0659340659341, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320432, Length=218, Percent_Identity=45.4128440366972, Blast_Score=198, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=41.8367346938776, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=28.2608695652174, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026816, Length=190, Percent_Identity=49.4736842105263, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17737899, Length=207, Percent_Identity=41.5458937198068, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24645822, Length=207, Percent_Identity=41.5458937198068, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=29.2817679558011, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=29.2817679558011, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=26.6304347826087, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=26.6304347826087, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24672; Mature: 24672

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSQCEIKRKIQMRIMLLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGTPLGL
CCCCHHHHHHEEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
EAKKVMDAGQLVSDELIIGLVKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHCCCEEEEEE
EIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDEESTVRKR
EECCCHHHHHHHHHCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHH
LDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTKSVASVSEEIVTVLS
HHHHHHHCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLVSQCEIKRKIQMRIMLLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGTPLGL
CCCCHHHHHHEEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
EAKKVMDAGQLVSDELIIGLVKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHCCCEEEEEE
EIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDEESTVRKR
EECCCHHHHHHHHHCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHH
LDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTKSVASVSEEIVTVLS
HHHHHHHCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA