Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 157961324

GI number: 157961324

Start: 1817514

End: 1817945

Strand: Direct

Name: ndk [H]

Synonym: Spea_1498

Alternate gene names: 157961324

Gene position: 1817514-1817945 (Clockwise)

Preceding gene: 157961323

Following gene: 157961325

Centisome position: 35.12

GC content: 46.76

Gene sequence:

>432_bases
ATGGCTATCGAACGTACTTTTTCTATCATTAAGCCTGATGCAGTTGCAAAAAACCACATTGGCGCTATCTACAACCGTTT
TGAAACGGCTGGCCTGAAAATCATCGCTTCTAAAATGATTCACCTAAGCAAAGAACAAGCTGAAGGTTTCTACGCTGAGC
ACAGCGAGCGTCCATTCTTTGGTGCACTAGTTGCATTCATGACGTCTGGTCCAATCATGGTGCAAACTCTTGAAGGCGAA
AACGCCGTTCTAGCTCACCGTGAAATCTTAGGTGCAACTAACCCTGCTGAAGCGGCTGAAGGTACTATCCGTGCTGATTT
CGCAGAAAGCATCGATGAGAACGCTGCTCATGGTTCTGATTCTGTAGCATCTGCAGAGCGTGAAGTTGCTTACTTCTTCA
GCGCTGAAGAGCTATGCCCACGCACTCGTTAA

Upstream 100 bases:

>100_bases
TATCTCAACTAGTTTGCGGCTTAAGGGTAGGCAATGGGGCTTTAATTTCGTATAATCCGCGCGAAAATTAAAACCCGTTT
ATATAAGAAGGAAGCTTTTC

Downstream 100 bases:

>100_bases
TTCGAACGCGTAAAAAAGGAGCCGAATGGCTCCTTTTTTTTGCTTTAAATTCTGCAAACTCTCCTTAATCCAATCGTTAT
CATTAACACTTAATTGTCCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIIASKMIHLSKEQAEGFYAEHSERPFFGALVAFMTSGPIMVQTLEGE
NAVLAHREILGATNPAEAAEGTIRADFAESIDENAAHGSDSVASAEREVAYFFSAEELCPRTR

Sequences:

>Translated_143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIIASKMIHLSKEQAEGFYAEHSERPFFGALVAFMTSGPIMVQTLEGE
NAVLAHREILGATNPAEAAEGTIRADFAESIDENAAHGSDSVASAEREVAYFFSAEELCPRTR
>Mature_142_residues
AIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIIASKMIHLSKEQAEGFYAEHSERPFFGALVAFMTSGPIMVQTLEGEN
AVLAHREILGATNPAEAAEGTIRADFAESIDENAAHGSDSVASAEREVAYFFSAEELCPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=48.1481481481481, Blast_Score=139, Evalue=6e-34,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=45.5882352941176, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=45.5882352941176, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=45.5882352941176, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=45.5882352941176, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=45.5882352941176, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=43.8848920863309, Blast_Score=129, Evalue=7e-31,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=43.8848920863309, Blast_Score=129, Evalue=8e-31,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=39.7058823529412, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=39.568345323741, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=39.568345323741, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=38.2352941176471, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=35.5555555555556, Blast_Score=83, Evalue=8e-17,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=30.6569343065693, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=28.4671532846715, Blast_Score=63, Evalue=7e-11,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=69.2307692307692, Blast_Score=210, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=44.4444444444444, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=47.7941176470588, Blast_Score=137, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=48.2014388489209, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=34.3283582089552, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15547; Mature: 15415

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIIASKMIHLSKEQAEGFYAEHSERPFF
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHH
GALVAFMTSGPIMVQTLEGENAVLAHREILGATNPAEAAEGTIRADFAESIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCCCC
SVASAEREVAYFFSAEELCPRTR
HHHHHHHHHHHEECHHHHCCCCC
>Mature Secondary Structure 
AIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIIASKMIHLSKEQAEGFYAEHSERPFF
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHH
GALVAFMTSGPIMVQTLEGENAVLAHREILGATNPAEAAEGTIRADFAESIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCCCC
SVASAEREVAYFFSAEELCPRTR
HHHHHHHHHHHEECHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA