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The map label for this gene is phhA [H]

Identifier: 157961274

GI number: 157961274

Start: 1762393

End: 1763184

Strand: Direct

Name: phhA [H]

Synonym: Spea_1448

Alternate gene names: 157961274

Gene position: 1762393-1763184 (Clockwise)

Preceding gene: 157961269

Following gene: 157961275

Centisome position: 34.06

GC content: 45.33

Gene sequence:

>792_bases
ATGAGTAAACCGCAAAACTATACAGCACGCTTGCCTGATGCAAATGGGTATATTGACTACCCTCAAGCTGAGCATGAAAT
TTGGTCAGAACTTTATCAAAGACAGAAAATCAATCTACCTGGGCGCGCCTGTCAAGAATATCTCGATGGGCTAAATAAGC
TTGGACTTGCGAGCGATAGAGTCCCGCAACTCTCTGAGGTTGACGATGTCTTACTACAAACAACGGGGTGGAAGACTGCC
GCGGTTCCTGCGCTGATCTCATTTGCTAAGTTCTTTGAGCTTCTGGCTAATAAGTCATTTCCGGTGGCAACTTTTATTCG
CAGCCGCGAAGAGCTTGATTACCTACAAGAGCCCGATATTTTTCATGAGGTATTTGGGCACTGTCCATTACTGACTAACC
CATCTTTCGCTCACTTTTCTCACCTTTATGGTCAGTTAGGGCTTGCTGCGAGTAAAGAGCAGCGGGTCTTCTTAGCAAGG
CTATACTGGTTTACTGTGGAGTTTGGCCTCCTAAAGTCTAAGAGCGATGAACTGAGGATTTACGGCGGAGGGATTTTAAG
CTCTCCTGGTGAGACTCTGTATGTTATGGGCACTGAGCCTGATATTAGGCCATTTGATTTAATCGATGTGCTACGTACAC
CTTACCGAATAGATATTATGCAGCCAATCTACTACGCCATTGAAGAGATTAGCGACCTAGGCGCAATAGCCGAGATGGAT
ATTATGGCTGCAGTAAACAAGGCACAAGAATTAGGATTATTTATAGCGACATTCCCAGCTAAAGCGGGTTAG

Upstream 100 bases:

>100_bases
TGCTTTAGTTAAGTATGAAGTAAGCACTCTTTTATCAGTTGTCGAGCATTTGTTTGAACTTTTGTTCTGCGTTACTGGTT
AGAATCATGAGTAAATAACT

Downstream 100 bases:

>100_bases
CTAAATCGGAGAGCGAAAGCCGGTTTAGTATTAAAAATAGAGTAACTAATAGCGTATTAGTAGCAATAATTAAGGAAGAG
AGATGACTGAATTAGCGCAA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSKPQNYTARLPDANGYIDYPQAEHEIWSELYQRQKINLPGRACQEYLDGLNKLGLASDRVPQLSEVDDVLLQTTGWKTA
AVPALISFAKFFELLANKSFPVATFIRSREELDYLQEPDIFHEVFGHCPLLTNPSFAHFSHLYGQLGLAASKEQRVFLAR
LYWFTVEFGLLKSKSDELRIYGGGILSSPGETLYVMGTEPDIRPFDLIDVLRTPYRIDIMQPIYYAIEEISDLGAIAEMD
IMAAVNKAQELGLFIATFPAKAG

Sequences:

>Translated_263_residues
MSKPQNYTARLPDANGYIDYPQAEHEIWSELYQRQKINLPGRACQEYLDGLNKLGLASDRVPQLSEVDDVLLQTTGWKTA
AVPALISFAKFFELLANKSFPVATFIRSREELDYLQEPDIFHEVFGHCPLLTNPSFAHFSHLYGQLGLAASKEQRVFLAR
LYWFTVEFGLLKSKSDELRIYGGGILSSPGETLYVMGTEPDIRPFDLIDVLRTPYRIDIMQPIYYAIEEISDLGAIAEMD
IMAAVNKAQELGLFIATFPAKAG
>Mature_262_residues
SKPQNYTARLPDANGYIDYPQAEHEIWSELYQRQKINLPGRACQEYLDGLNKLGLASDRVPQLSEVDDVLLQTTGWKTAA
VPALISFAKFFELLANKSFPVATFIRSREELDYLQEPDIFHEVFGHCPLLTNPSFAHFSHLYGQLGLAASKEQRVFLARL
YWFTVEFGLLKSKSDELRIYGGGILSSPGETLYVMGTEPDIRPFDLIDVLRTPYRIDIMQPIYYAIEEISDLGAIAEMDI
MAAVNKAQELGLFIATFPAKAG

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=219, Percent_Identity=37.4429223744292, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI88900505, Length=219, Percent_Identity=37.4429223744292, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI88900501, Length=219, Percent_Identity=37.4429223744292, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4557819, Length=219, Percent_Identity=36.5296803652968, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4759248, Length=219, Percent_Identity=34.703196347032, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI31795563, Length=219, Percent_Identity=33.7899543378995, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71980736, Length=227, Percent_Identity=32.15859030837, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17531391, Length=218, Percent_Identity=36.697247706422, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI115533973, Length=223, Percent_Identity=30.0448430493274, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115532103, Length=223, Percent_Identity=30.0448430493274, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71980731, Length=158, Percent_Identity=31.0126582278481, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136774, Length=220, Percent_Identity=35.9090909090909, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17136776, Length=220, Percent_Identity=35.9090909090909, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24660393, Length=216, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI62472054, Length=216, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24654994, Length=187, Percent_Identity=37.9679144385027, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 29650; Mature: 29519

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPQNYTARLPDANGYIDYPQAEHEIWSELYQRQKINLPGRACQEYLDGLNKLGLASDR
CCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
VPQLSEVDDVLLQTTGWKTAAVPALISFAKFFELLANKSFPVATFIRSREELDYLQEPDI
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
FHEVFGHCPLLTNPSFAHFSHLYGQLGLAASKEQRVFLARLYWFTVEFGLLKSKSDELRI
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
YGGGILSSPGETLYVMGTEPDIRPFDLIDVLRTPYRIDIMQPIYYAIEEISDLGAIAEMD
EECCEECCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IMAAVNKAQELGLFIATFPAKAG
HHHHHHHHHHCCEEEEECCCCCC
>Mature Secondary Structure 
SKPQNYTARLPDANGYIDYPQAEHEIWSELYQRQKINLPGRACQEYLDGLNKLGLASDR
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
VPQLSEVDDVLLQTTGWKTAAVPALISFAKFFELLANKSFPVATFIRSREELDYLQEPDI
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
FHEVFGHCPLLTNPSFAHFSHLYGQLGLAASKEQRVFLARLYWFTVEFGLLKSKSDELRI
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
YGGGILSSPGETLYVMGTEPDIRPFDLIDVLRTPYRIDIMQPIYYAIEEISDLGAIAEMD
EECCEECCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IMAAVNKAQELGLFIATFPAKAG
HHHHHHHHHHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]