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The map label for this gene is tadA [H]

Identifier: 157961143

GI number: 157961143

Start: 1602580

End: 1603071

Strand: Direct

Name: tadA [H]

Synonym: Spea_1315

Alternate gene names: 157961143

Gene position: 1602580-1603071 (Clockwise)

Preceding gene: 157961142

Following gene: 157961145

Centisome position: 30.97

GC content: 48.17

Gene sequence:

>492_bases
ATGAAAATGGCGATGGATATGGCGATAAAAGCGGAAGAAAAGGGTGAAGTGCCTGTCGGAGCCGTGCTGGTTAAAGACGG
AGAAGTCGTCAGCGCCGGATTCAATTTTAGTATTGGTTTGCACGACCCAAGCGCACATGCAGAGATGCAGTGTTTGCGCC
AAGCAGGTCAGATAATGCAAAACTACCGCTTACTCGACACGACCTTGTATGTGACGCTGGAACCCTGTGCAATGTGCGCA
GGAGCTATTGTACACTCTCGAATTAATCGCTTGGTATTTGGCGCGAGAGATGAAAAAACCGGCGCAGCAGGCACTGTGAT
CGACATAGTGCGACACAGTGCTTTTAATCATCAGGTTGATGTTAGCTCTGGCGTGCTAGAAACTGAGTGTAGCGAACAGC
TCAGCGCATTTTTCAAGCGGAGAAGAAAAGAGAAAAAAGCCGCTAAAGCCTTGGCAAAGCAACAAGCCTTGTTATCGACT
CCTAAGAGTTAA

Upstream 100 bases:

>100_bases
AGGTGCTTCGGCACCTTTTTTATTGGCGCTAGCGTCAACATTATCTTTGGAGCTTGATTTGTCAAAGTTTGAATCATCAC
AACAGCAAGATATCCATTTC

Downstream 100 bases:

>100_bases
AAAAAAGCATCATCCGAAGGCTTAATAAATGCGAAGAACTGTTTGTGTCTGTTAAGTACTTTTAGGTGGCGTGTTTTCAA
TTGGCTACGACGACGCGCCG

Product: zinc-binding CMP/dCMP deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MKMAMDMAIKAEEKGEVPVGAVLVKDGEVVSAGFNFSIGLHDPSAHAEMQCLRQAGQIMQNYRLLDTTLYVTLEPCAMCA
GAIVHSRINRLVFGARDEKTGAAGTVIDIVRHSAFNHQVDVSSGVLETECSEQLSAFFKRRRKEKKAAKALAKQQALLST
PKS

Sequences:

>Translated_163_residues
MKMAMDMAIKAEEKGEVPVGAVLVKDGEVVSAGFNFSIGLHDPSAHAEMQCLRQAGQIMQNYRLLDTTLYVTLEPCAMCA
GAIVHSRINRLVFGARDEKTGAAGTVIDIVRHSAFNHQVDVSSGVLETECSEQLSAFFKRRRKEKKAAKALAKQQALLST
PKS
>Mature_163_residues
MKMAMDMAIKAEEKGEVPVGAVLVKDGEVVSAGFNFSIGLHDPSAHAEMQCLRQAGQIMQNYRLLDTTLYVTLEPCAMCA
GAIVHSRINRLVFGARDEKTGAAGTVIDIVRHSAFNHQVDVSSGVLETECSEQLSAFFKRRRKEKKAAKALAKQQALLST
PKS

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=163, Percent_Identity=33.1288343558282, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI145693172, Length=149, Percent_Identity=57.7181208053691, Blast_Score=194, Evalue=2e-51,
Organism=Escherichia coli, GI1786616, Length=130, Percent_Identity=32.3076923076923, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554608, Length=105, Percent_Identity=39.0476190476191, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17541138, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322425, Length=178, Percent_Identity=28.6516853932584, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325319, Length=96, Percent_Identity=37.5, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355527, Length=162, Percent_Identity=29.6296296296296, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 17721; Mature: 17721

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMAMDMAIKAEEKGEVPVGAVLVKDGEVVSAGFNFSIGLHDPSAHAEMQCLRQAGQIMQ
CCCHHHHHEECCCCCCCCEEEEEEECCCEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
NYRLLDTTLYVTLEPCAMCAGAIVHSRINRLVFGARDEKTGAAGTVIDIVRHSAFNHQVD
CCCHHHEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEC
VSSGVLETECSEQLSAFFKRRRKEKKAAKALAKQQALLSTPKS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKMAMDMAIKAEEKGEVPVGAVLVKDGEVVSAGFNFSIGLHDPSAHAEMQCLRQAGQIMQ
CCCHHHHHEECCCCCCCCEEEEEEECCCEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
NYRLLDTTLYVTLEPCAMCAGAIVHSRINRLVFGARDEKTGAAGTVIDIVRHSAFNHQVD
CCCHHHEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEC
VSSGVLETECSEQLSAFFKRRRKEKKAAKALAKQQALLSTPKS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]