Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 157961142

GI number: 157961142

Start: 1600874

End: 1602451

Strand: Direct

Name: guaA [H]

Synonym: Spea_1314

Alternate gene names: 157961142

Gene position: 1600874-1602451 (Clockwise)

Preceding gene: 157961141

Following gene: 157961143

Centisome position: 30.94

GC content: 46.7

Gene sequence:

>1578_bases
ATGAGCAACATTCATGAGCATAAGATCCTCATATTAGATTTTGGATCGCAATACACTCAACTGATCGCCCGTCGTATTCG
TGAAATCGGTGTGTATTGTGAACTTTGGGCTTGGGATGTTTCTGAAGAGCAAATTCGTGAATTCGCTCCAAACGGCATTA
TCTTAGCGGGTGGCCCTGAAAGTGTTACCGCTGAGAACTCACCTCGAGCTCCAGAATATGTGTTTAACGCTGGCGTACCA
GTACTAGGTATTTGTTACGGCATGCAAACCATGTCTGAGCAGCTTGGTGGTAAAGTTATTCAAGGTGTGGGTGAAGGTGA
GTTTGGCTACGCACAAGTTGAGGTGCAAACTGAGTCTGCACTGTTTAAAGCTATCGAAGACGCGGTAAGCGAAACCGGTA
AGCCGTTGCTTGACGTGTGGATGAGCCACGGTGATAAGGTTTCTGCAATTCCTGAAGGGTTTGTTGCTGTCGCTAAGACT
GAAACATGTCCGTTTGCCGCTATGGCGAATGAAGACAAGCAGTTCTACGGCGTGCAGTTCCACCCAGAAGTGACTCACAC
TCGTCAAGGTAAGCGTATGCTTGAGCATTTCGCCCTTGAGATCTGTGGCTGTCCAGCAAACTGGAAGCCATCTTCAATCA
TTGAAGATGCGATTGAGCGTTTAAAAGAGCAGATCGGTGATGACGAAGTTATCTTAGGTCTATCGGGTGGTGTTGACTCA
TCAGTTGTTGCTATGCTTTTGCACCGCGCAATTGGCGACAAGCTAACATGTGTGTTTGTTGATAACGGTCTACTACGTCT
AAACGAAGCGCAGCAAGTAATGGATATGTTTGGCGACCACTTTGGTCTAAACATCGTTCATGTCGATGCCGAGAACCGTT
TCTTAGATGCAATGGCTGGTGAAGCTGAGCCTGAAGCAAAGCGTAAGATCATCGGCCGCGTATTCGTTGAGATCTTCGAT
GAAGAATCAAAGAAATGCGTTAATGCTAAATGGCTTGCACAGGGCACCATCTACCCAGACGTTATCGAGTCTGCAGGTAG
CGCTACAGGTAAGGCACACTGCATTAAGTCACACCATAACGTTGGCGGTTTGCCAGATGATATGGCAATGGGTCTGGTTG
AGCCATTACGTGAACTGTTTAAAGATGAAGTACGTAAGATTGGCCTAGAGCTAGGTCTTCCATACGACATGCTTTACCGT
CACCCGTTCCCAGGACCAGGTCTTGGTGTACGTGTGCTTGGCGAAGTGAAGAAAGAATACTGTGACTTGCTACGTCTAGC
CGATGCGATTTTCATCGAAGAGCTACATAAAGCTGACCTTTATAACAAGGTAAGCCAAGCATTTACTGTGTTCCTACCAG
TACGCTCTGTTGGCGTAATGGGCGATGGTCGTAAGTACGACTGGGTTGTATCACTACGTGCAGTTGAAACTATCGACTTT
ATGACGGCGCATTGGGCACACCTACCTTATGATTTCCTAGGTCGTGTATCTAATCGTATCATCAACGAAGTAGACGGTAT
TTCACGTGTGGTTTACGACATTTCTGGTAAGCCACCTGCAACAATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GACATATAATGTCGCCTTTAAATTAAGCCAAGTAGTAGATTCGCAGAGTACTCACTGCTTGGTTAGTTAACAATAAAGAA
AAATAGAGATAAGGTACCCC

Downstream 100 bases:

>100_bases
TCTTAGGATTATAATGACTCTAGAATAAAGGTGCTTCGGCACCTTTTTTATTGGCGCTAGCGTCAACATTATCTTTGGAG
CTTGATTTGTCAAAGTTTGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVSEEQIREFAPNGIILAGGPESVTAENSPRAPEYVFNAGVP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQVEVQTESALFKAIEDAVSETGKPLLDVWMSHGDKVSAIPEGFVAVAKT
ETCPFAAMANEDKQFYGVQFHPEVTHTRQGKRMLEHFALEICGCPANWKPSSIIEDAIERLKEQIGDDEVILGLSGGVDS
SVVAMLLHRAIGDKLTCVFVDNGLLRLNEAQQVMDMFGDHFGLNIVHVDAENRFLDAMAGEAEPEAKRKIIGRVFVEIFD
EESKKCVNAKWLAQGTIYPDVIESAGSATGKAHCIKSHHNVGGLPDDMAMGLVEPLRELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRLADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MSNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVSEEQIREFAPNGIILAGGPESVTAENSPRAPEYVFNAGVP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQVEVQTESALFKAIEDAVSETGKPLLDVWMSHGDKVSAIPEGFVAVAKT
ETCPFAAMANEDKQFYGVQFHPEVTHTRQGKRMLEHFALEICGCPANWKPSSIIEDAIERLKEQIGDDEVILGLSGGVDS
SVVAMLLHRAIGDKLTCVFVDNGLLRLNEAQQVMDMFGDHFGLNIVHVDAENRFLDAMAGEAEPEAKRKIIGRVFVEIFD
EESKKCVNAKWLAQGTIYPDVIESAGSATGKAHCIKSHHNVGGLPDDMAMGLVEPLRELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRLADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
>Mature_524_residues
SNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVSEEQIREFAPNGIILAGGPESVTAENSPRAPEYVFNAGVPV
LGICYGMQTMSEQLGGKVIQGVGEGEFGYAQVEVQTESALFKAIEDAVSETGKPLLDVWMSHGDKVSAIPEGFVAVAKTE
TCPFAAMANEDKQFYGVQFHPEVTHTRQGKRMLEHFALEICGCPANWKPSSIIEDAIERLKEQIGDDEVILGLSGGVDSS
VVAMLLHRAIGDKLTCVFVDNGLLRLNEAQQVMDMFGDHFGLNIVHVDAENRFLDAMAGEAEPEAKRKIIGRVFVEIFDE
ESKKCVNAKWLAQGTIYPDVIESAGSATGKAHCIKSHHNVGGLPDDMAMGLVEPLRELFKDEVRKIGLELGLPYDMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRLADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFM
TAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=566, Percent_Identity=34.6289752650177, Blast_Score=291, Evalue=1e-78,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=82.4091778202677, Blast_Score=909, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=34.6020761245675, Blast_Score=281, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=34.6020761245675, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=34.6020761245675, Blast_Score=280, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=49.0494296577947, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=35.6382978723404, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58197; Mature: 58066

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVSEEQIREFAPNGIILAGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCCEEEECCCC
SVTAENSPRAPEYVFNAGVPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQVEVQTESA
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEEEHHHH
LFKAIEDAVSETGKPLLDVWMSHGDKVSAIPEGFVAVAKTETCPFAAMANEDKQFYGVQF
HHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHHCCCCCEEEEEEE
HPEVTHTRQGKRMLEHFALEICGCPANWKPSSIIEDAIERLKEQIGDDEVILGLSGGVDS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGDKLTCVFVDNGLLRLNEAQQVMDMFGDHFGLNIVHVDAENRFLDAMAG
HHHHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCC
EAEPEAKRKIIGRVFVEIFDEESKKCVNAKWLAQGTIYPDVIESAGSATGKAHCIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCHHHHHCCCC
VGGLPDDMAMGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRLADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC
>Mature Secondary Structure 
SNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVSEEQIREFAPNGIILAGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCCEEEECCCC
SVTAENSPRAPEYVFNAGVPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQVEVQTESA
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEEEHHHH
LFKAIEDAVSETGKPLLDVWMSHGDKVSAIPEGFVAVAKTETCPFAAMANEDKQFYGVQF
HHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHHCCCCCEEEEEEE
HPEVTHTRQGKRMLEHFALEICGCPANWKPSSIIEDAIERLKEQIGDDEVILGLSGGVDS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGDKLTCVFVDNGLLRLNEAQQVMDMFGDHFGLNIVHVDAENRFLDAMAG
HHHHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCC
EAEPEAKRKIIGRVFVEIFDEESKKCVNAKWLAQGTIYPDVIESAGSATGKAHCIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCHHHHHCCCC
VGGLPDDMAMGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
CDLLRLADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEVDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA