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The map label for this gene is tkt1 [H]

Identifier: 157960616

GI number: 157960616

Start: 974163

End: 976154

Strand: Direct

Name: tkt1 [H]

Synonym: Spea_0788

Alternate gene names: 157960616

Gene position: 974163-976154 (Clockwise)

Preceding gene: 157960613

Following gene: 157960617

Centisome position: 18.83

GC content: 49.05

Gene sequence:

>1992_bases
ATGTCATCTCGTAAAGAACTCGCAAACGCAATCCGCGCATTGACCATGGATGCTGTTCAAAAAGCCAATTCAGGTCACCC
AGGTGCACCAATGGGGATGGCTGATATTGCTGAAGTGCTATGGAATGATTTCCTAAAGCACAACCCAAACAACCCTGAGT
GGGTTGATCGTGACCGTTTTATTCTTTCTAACGGCCACGGCTCTATGCTTATCTACTCTTTGCTACACCTTACAGGTTAT
GCACTGCCTATCGAAGAGTTGAAAAACTTCCGCCAGCTTCACTCTAAGACCCCAGGTCACCCTGAATACGGTTACACACC
TGGTGTTGAAACGACTACCGGCCCACTAGGCGCTGGTATCAGTAACGCTGTGGGTATGGCGATTGCTGAGAAGACATTGG
CTGCACAGTTTAACCAGCCTGGTCACGACATCGTTGATCACTTCACATACTGCTTCCTAGGTGATGGCTGTTTGATGGAA
GGTATCTCTCACGAAGCGTGTTCTCTAGCCGGCACTTTAGGCCTAGGCAAGCTAATCGCATTCTGGGATGACAACGGTAT
CTCTATCGATGGTCACGTAGAAGGTTGGTTCACTGACGATACGCCTAAGCGTTTTGAGTCTTACGGCTGGCATGTCATTG
CTAACGTAGACGGTCACGACAGCGACGCAATTCGCGCAGCTATCGAAGAAGCTAAGTCTGTTACAGACAAGCCAACGATG
ATCTGCTGTAAAACGACTATCGGTTTCGGTTCTCCAAACAAGTCTGGCAGCCACGATTGTCACGGCGCACCACTAGGTGA
TGCTGAAATTGCTGCTGCACGTGAATTCCTTGGTTGGAACCACGGCGCATTCGAAATTCCTGAAAACGTTTACGCGGGTT
GGGATGCTAAAGAAACTGGCGCTGCGAATGAAGCAAGCTGGAACGACAAGTTCGCTGCCTATGAAGCTGCTTTCCCTGAA
TTAGCTGCTGAATATAAGCGTCGTGTTATCACGGGTGACTTGCCTGCAGATTTCGAAGAAAAAGCACAAGCTTTCGTTCA
AGAGTGTCAAGATAAAGCCGAAGGTATTGCTAGCCGTAAAGCATCACAAAATGCGATTGGTGCATTTGGTGCCATCCTAC
CTGAAATGCTAGGTGGCTCGGCAGATCTAGCCGGTTCAAACCTAACGCTTTGGTCTGGTTCTAAAGGCATTCAAGACGAC
CCAGCTGGTAACTACATCTACTACGGTGTACGTGAATTCGGTATGAGCGGTATCATGAACGGTGCTTCTCTACACGGTGG
TTTCATCAACTACGGCGCAACTTTCATGATGTTCATGGAATACGCGCGTAACGCAGTACGTATGTCTGCACTGATGGGCA
TTCAGAACATCTTCGTTTATACCCATGACTCTATCGGTCAAGGTGAAGATGGTCCTACTCACCAGCCAGTTGAACAGCTT
GCAAACCTTCGTATGACACCAAACATGACAGTATGGCGTCCATGTGATGCGGCTGAAACTGCTGTATCTTGGAAGAATGC
AATTGAGCGCCGTAACGCGCCAACATCGCTAATCTTCAGCCGTCAAAACCTACCTGCGCAAGCACGTACTGCCGAGCAGT
TAGCTAACGTAGTTAAAGGTGGTTATGTACTAAGTGATTGCGCTGGCACGCCAGACCTAATCCTTATTGCTACTGGCTCT
GAAGTTCAGCTAGCACTTGATTCTGCTGCTGCGCTAACTGAGCAAGGTCAGAAGGTTCGCGTAGTGTCTATGCCATCGAC
TAACGAGTTCGATAAGCAAGACGCTGCTTATAAAGAGTCGGTACTACCAAGCTCAGTGACTAAGCGTGTGGCGATTGAAG
CGGCTCACGTTGATTTCTGGCACAAGTATGTTGGCTTTGGCGGCGCAGTAGTGGGCATGTCTACCTTCGGTGAGTCAGCG
CCAGGCGGCGACTTGCTGAAGCACTTTGGCTTCACAGTTGACAACGTTGTAGCTACCGTTAACGGGCTATAA

Upstream 100 bases:

>100_bases
TGGCTCCCAAATTTGCTGTGGTGAAGGGAAAAGCAAATACAAAGTTGCGGCCTTTCACTCTATCTAAGCCTCAATACCTC
AAAACCAAGCAGGAGAGAGC

Downstream 100 bases:

>100_bases
TTAACTGCGGTGTTAAGGCAAATGATACAACGGCTTACCTAATGAGGTAGGCCGTTGTTTTATCAATAAACAGGCTGCTA
AAGGGATAGAAAGCTTTCAT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MSSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPEWVDRDRFILSNGHGSMLIYSLLHLTGY
ALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNQPGHDIVDHFTYCFLGDGCLME
GISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEEAKSVTDKPTM
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHGAFEIPENVYAGWDAKETGAANEASWNDKFAAYEAAFPE
LAAEYKRRVITGDLPADFEEKAQAFVQECQDKAEGIASRKASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDD
PAGNYIYYGVREFGMSGIMNGASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKGGYVLSDCAGTPDLILIATGS
EVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKESVLPSSVTKRVAIEAAHVDFWHKYVGFGGAVVGMSTFGESA
PGGDLLKHFGFTVDNVVATVNGL

Sequences:

>Translated_663_residues
MSSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPEWVDRDRFILSNGHGSMLIYSLLHLTGY
ALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNQPGHDIVDHFTYCFLGDGCLME
GISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEEAKSVTDKPTM
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHGAFEIPENVYAGWDAKETGAANEASWNDKFAAYEAAFPE
LAAEYKRRVITGDLPADFEEKAQAFVQECQDKAEGIASRKASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDD
PAGNYIYYGVREFGMSGIMNGASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKGGYVLSDCAGTPDLILIATGS
EVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKESVLPSSVTKRVAIEAAHVDFWHKYVGFGGAVVGMSTFGESA
PGGDLLKHFGFTVDNVVATVNGL
>Mature_662_residues
SSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPEWVDRDRFILSNGHGSMLIYSLLHLTGYA
LPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGISNAVGMAIAEKTLAAQFNQPGHDIVDHFTYCFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEEAKSVTDKPTMI
CCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHGAFEIPENVYAGWDAKETGAANEASWNDKFAAYEAAFPEL
AAEYKRRVITGDLPADFEEKAQAFVQECQDKAEGIASRKASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDDP
AGNYIYYGVREFGMSGIMNGASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQLA
NLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKGGYVLSDCAGTPDLILIATGSE
VQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKESVLPSSVTKRVAIEAAHVDFWHKYVGFGGAVVGMSTFGESAP
GGDLLKHFGFTVDNVVATVNGL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=682, Percent_Identity=25.366568914956, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI4507521, Length=682, Percent_Identity=25.366568914956, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI133778974, Length=579, Percent_Identity=25.9067357512953, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI225637459, Length=262, Percent_Identity=24.4274809160305, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=73.0015082956259, Blast_Score=1042, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=67.5265553869499, Blast_Score=964, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=588, Percent_Identity=25.8503401360544, Blast_Score=158, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=663, Percent_Identity=48.2654600301659, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319593, Length=667, Percent_Identity=45.1274362818591, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45551847, Length=679, Percent_Identity=26.3622974963181, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI45550715, Length=679, Percent_Identity=26.3622974963181, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24666278, Length=595, Percent_Identity=25.0420168067227, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24645119, Length=645, Percent_Identity=25.8914728682171, Blast_Score=145, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71236; Mature: 71104

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPEWVDRDRF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILSNGHGSMLIYSLLHLTGYALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKTLAAQFNQPGHDIVDHFTYCFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCEEE
FWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEEAKSVTDKPTM
EECCCCEEECCCCCCEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCE
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHGAFEIPENVYAGWDAKETG
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCCHHHCCCCCHHCC
AANEASWNDKFAAYEAAFPELAAEYKRRVITGDLPADFEEKAQAFVQECQDKAEGIASRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDDPAGNYIYYGVREFGMSGIMN
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHCHHHCCC
GASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHH
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
GYVLSDCAGTPDLILIATGSEVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKES
CEEEECCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
VLPSSVTKRVAIEAAHVDFWHKYVGFGGAVVGMSTFGESAPGGDLLKHFGFTVDNVVATV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCHHHHHHHCCCHHHHHHHH
NGL
CCC
>Mature Secondary Structure 
SSRKELANAIRALTMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPNNPEWVDRDRF
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
ILSNGHGSMLIYSLLHLTGYALPIEELKNFRQLHSKTPGHPEYGYTPGVETTTGPLGAGI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKTLAAQFNQPGHDIVDHFTYCFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHCCCCEEE
FWDDNGISIDGHVEGWFTDDTPKRFESYGWHVIANVDGHDSDAIRAAIEEAKSVTDKPTM
EECCCCEEECCCCCCEECCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCE
ICCKTTIGFGSPNKSGSHDCHGAPLGDAEIAAAREFLGWNHGAFEIPENVYAGWDAKETG
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCCHHHCCCCCHHCC
AANEASWNDKFAAYEAAFPELAAEYKRRVITGDLPADFEEKAQAFVQECQDKAEGIASRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASQNAIGAFGAILPEMLGGSADLAGSNLTLWSGSKGIQDDPAGNYIYYGVREFGMSGIMN
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHHCHHHCCC
GASLHGGFINYGATFMMFMEYARNAVRMSALMGIQNIFVYTHDSIGQGEDGPTHQPVEQL
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHH
ANLRMTPNMTVWRPCDAAETAVSWKNAIERRNAPTSLIFSRQNLPAQARTAEQLANVVKG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
GYVLSDCAGTPDLILIATGSEVQLALDSAAALTEQGQKVRVVSMPSTNEFDKQDAAYKES
CEEEECCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
VLPSSVTKRVAIEAAHVDFWHKYVGFGGAVVGMSTFGESAPGGDLLKHFGFTVDNVVATV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCHHHHHHHCCCHHHHHHHH
NGL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]