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The map label for this gene is epd [H]

Identifier: 157960617

GI number: 157960617

Start: 976253

End: 977272

Strand: Direct

Name: epd [H]

Synonym: Spea_0789

Alternate gene names: 157960617

Gene position: 976253-977272 (Clockwise)

Preceding gene: 157960616

Following gene: 157960618

Centisome position: 18.87

GC content: 47.35

Gene sequence:

>1020_bases
ATGATCAGAGTCGCTATTAATGGCTACGGCCGCATTGGTCGTTCAATTCTTCGTGCACTGTATGAGTCTGCAAAACGCGA
CCGTATTCAAATTGTGGCGATTAACGAGTTGGCAAAACCAGAAGCCATGCTTCATTTGACTCAGTACGACACCACTCACG
GCCGCTTCCACACCCAAGTTAAGCTCGATAATCAGCATATGATTATTGGCGACGATGCCATTAAGCTGCTGCATGAACCC
GATCCTGCTAAATTGCCCTGGAAAGAGATGGATATCGATATCGTTTTCGAAGCCACGGGTGTAATTAACGACAGGCTGGA
ATGTGAGGCGCACATTCAAGCTGGCGCCAAACAAGTATTAATCAGTCATCCATCATCAAGTGATGTCGATGCCACCATAG
TTTTTGGTGTGAACCAAGATTTACTTAAGGCCGAACATACGGTTGTGTCTAATGCCTCTTGCACAACAAACTGTATCGTA
CCGGTTATCGATGTGCTCGACAGGCACTTCGAAGTTAAAAGTGGTGCCATTACCACTATCCATTCGGCGATGAACGATCA
GCAGGTGATCGATGCCTATCATGACGATCTGCGAAGAACCCGCGCCGCTGGGCAATCAATTATTCCAGTAGATACTAAAC
TTGCTCGTGGTATTGAGCGCATCTTGCCGCATATGAAAGACAAGTTTGAAGCTATCTCTGTTCGAGTTCCGACCATCAAT
GTTACCGCTATCGACCTTTCCGTTACGCTAAATAAGCGCGTCGATATCGAGACCGTTAATCAGGTACTAAAACAAGCCAC
TGAAGGTTCTTTCTCAGGCGTGGTCGGCTTTACCAATGAGCCGTTAGTCTCTTGTGATTTTAACCACGACCCGCGCTCAA
GCATTGTCGATGGCACCCAGACTCGCGTCAGCGATGGCCACTTGGTCAAGTTACTGCTCTGGTGTGATAACGAGTGGGGC
TTTGCTAACCGCATGCTAGATACCAGTTTAGAGATGATAAAGGCTAAAAGCAGGACCTAG

Upstream 100 bases:

>100_bases
AATTAACTGCGGTGTTAAGGCAAATGATACAACGGCTTACCTAATGAGGTAGGCCGTTGTTTTATCAATAAACAGGCTGC
TAAAGGGATAGAAAGCTTTC

Downstream 100 bases:

>100_bases
GTTTGAGAGCTGAGAAGGTCCTAGGTTTTAAGAGCTGAGAAGGTCCTAGGTTCTAGGAAAAGCTAAGACGGTGCGAGCCG
AGACGGAAAAGCTAAGCCAG

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEP
DPAKLPWKEMDIDIVFEATGVINDRLECEAHIQAGAKQVLISHPSSSDVDATIVFGVNQDLLKAEHTVVSNASCTTNCIV
PVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
VTAIDLSVTLNKRVDIETVNQVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWG
FANRMLDTSLEMIKAKSRT

Sequences:

>Translated_339_residues
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEP
DPAKLPWKEMDIDIVFEATGVINDRLECEAHIQAGAKQVLISHPSSSDVDATIVFGVNQDLLKAEHTVVSNASCTTNCIV
PVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
VTAIDLSVTLNKRVDIETVNQVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWG
FANRMLDTSLEMIKAKSRT
>Mature_339_residues
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQVKLDNQHMIIGDDAIKLLHEP
DPAKLPWKEMDIDIVFEATGVINDRLECEAHIQAGAKQVLISHPSSSDVDATIVFGVNQDLLKAEHTVVSNASCTTNCIV
PVIDVLDRHFEVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
VTAIDLSVTLNKRVDIETVNQVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQTRVSDGHLVKLLLWCDNEWG
FANRMLDTSLEMIKAKSRT

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=334, Percent_Identity=38.9221556886228, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI7657116, Length=330, Percent_Identity=35.4545454545455, Blast_Score=225, Evalue=5e-59,
Organism=Escherichia coli, GI1789295, Length=337, Percent_Identity=63.7982195845697, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1788079, Length=327, Percent_Identity=40.3669724770642, Blast_Score=256, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17534677, Length=333, Percent_Identity=39.039039039039, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17534679, Length=333, Percent_Identity=38.7387387387387, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI32566163, Length=335, Percent_Identity=37.3134328358209, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17568413, Length=335, Percent_Identity=37.3134328358209, Blast_Score=237, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6322468, Length=337, Percent_Identity=38.5756676557863, Blast_Score=262, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6321631, Length=337, Percent_Identity=38.2789317507418, Blast_Score=259, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6322409, Length=329, Percent_Identity=38.9057750759878, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17933600, Length=330, Percent_Identity=36.3636363636364, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI18110149, Length=330, Percent_Identity=36.3636363636364, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI85725000, Length=330, Percent_Identity=36.3636363636364, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI22023983, Length=330, Percent_Identity=36.3636363636364, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19922412, Length=333, Percent_Identity=34.5345345345345, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.72 [H]

Molecular weight: Translated: 37715; Mature: 37715

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQV
CEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEE
KLDNQHMIIGDDAIKLLHEPDPAKLPWKEMDIDIVFEATGVINDRLECEAHIQAGAKQVL
EECCCEEEECHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCCCHHHHHHHHCCCEEEE
ISHPSSSDVDATIVFGVNQDLLKAEHTVVSNASCTTNCIVPVIDVLDRHFEVKSGAITTI
EECCCCCCCCEEEEEECCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEECCCCEEEH
HSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECEEE
VTAIDLSVTLNKRVDIETVNQVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQ
EEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHCCCCC
TRVSDGHLVKLLLWCDNEWGFANRMLDTSLEMIKAKSRT
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRVAINGYGRIGRSILRALYESAKRDRIQIVAINELAKPEAMLHLTQYDTTHGRFHTQV
CEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEE
KLDNQHMIIGDDAIKLLHEPDPAKLPWKEMDIDIVFEATGVINDRLECEAHIQAGAKQVL
EECCCEEEECHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCCCHHHHHHHHCCCEEEE
ISHPSSSDVDATIVFGVNQDLLKAEHTVVSNASCTTNCIVPVIDVLDRHFEVKSGAITTI
EECCCCCCCCEEEEEECCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCEEECCCCEEEH
HSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTIN
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECEEE
VTAIDLSVTLNKRVDIETVNQVLKQATEGSFSGVVGFTNEPLVSCDFNHDPRSSIVDGTQ
EEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCHHHCCCCC
TRVSDGHLVKLLLWCDNEWGFANRMLDTSLEMIKAKSRT
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA