Click here to switch to the map view.

The map label for this gene is sdaA [H]

Identifier: 157960600

GI number: 157960600

Start: 957934

End: 959301

Strand: Direct

Name: sdaA [H]

Synonym: Spea_0772

Alternate gene names: 157960600

Gene position: 957934-959301 (Clockwise)

Preceding gene: 157960599

Following gene: 157960602

Centisome position: 18.51

GC content: 46.35

Gene sequence:

>1368_bases
ATGTTTAGCGCATTTGATATTTTTAAGATAGGTGTGGGTCCATCGAGCTCTCATACTGTCGGGCCGATGAAGGCCGCCAA
AGAGTTTATCGATGATGTTCGTCAAACCGGCCAATTTGAACAAGTGACTCGTTTAGGCGTTGAGATTTTTGGTTCTTTAT
CGTTAACCGGTAAGGGTCACCATACCGATATCGCTATCATTGTTGGTTTAGGTGGTAACTCACCTGAGAGCGTAGATATC
GATGCGATTCCTGGTTTTATTGCTGACGTTGAGCAAACTAAGAAACTGCCTATGGGCAGCGAAAAGCAGCTAGTAGACTT
TGGTCATGATGCGGTGGTTTTCCACAGCCATGCATTACCATTGCACGAAAATGGCATGATGTTGCACGCATACAATGGTG
ATGAGCTTGTATTAAGCAAGACATACTATTCAGTAGGCGGTGGCTTTATTGTTGAAGAATCAAAATTCGGCAAAGAAGTT
GAAAACCCAGTTGCAGTGCCATACCCGTTTAACTTTGCAGATGAGCTACTAGCGACCTGTAAAGAAACAGGCTTAAGCAT
CAGCAGCATCATGTTCAAGAATGAATTGTGTTTCAACAGTGAAGAAGCTATTTACGATGGCTTTGGTGCAGTATGGGCAA
CCATGCATCAAGCAATTGAAAAAGGCTGTCAAACTGAAGGTGTACTGGCTGGTCCGCTAAAAGTAGCTCGTCGTGCACCA
GCACTTTATCGCCAGTTATTAACCGGTGAGCGTTTATCTAGCGACCCAATGGAAATCGTTGATTGGATCAACGTATTTGC
AATGGCAGTTAGCGAAGAAAACGCTGCTGGTGGTCGTGTAGTAACGTCTCCAACTAACGGTGCTGCGGGTATTATCCCTG
CGGTATTGGCTTATTATGACAAGTTCATTAAGCCTGTTGGTAAGCAAGATTACACTCGCTTCTTCCTAGCGGCAGCTGCA
GTGGGATCACTATACAAGCGTAACGCTTCTATCTCGGGCGCCGAAGTAGGTTGTCAGGGTGAAGTTGGCGTAGCCTGTTC
TATGGCGGCTGCAGGTCTTGCAGAAATCATGGGTGCTAACCCTGAGCAAGTATGTATGGCGGCTGAAATTGGCATGGAGC
ATAACCTAGGTCTAACTTGTGACCCAGTTGCTGGCCAAGTACAGGTTCCATGCATCGAGCGTAATGCGATTGCAGCGGTT
AAGGCGATTAACTCTACGCGTATGGCGATGCGCCGTAACTGCGCACCAAAGGTGAGCTTAGATAAAGTTATCGCGACTAT
GTATGAGACGGGCAAAGATATGCACGTTAAGTACCGCGAAACTAGCCAAGGTGGTTTGGCTATTAAGGTAACCAGCATCT
GCGGTTAA

Upstream 100 bases:

>100_bases
AACGCTTTTTTAAGCGTTAGCCATTAAGTTATATGGTTCCATTATTGTTTGACTAGGCTAGGAATTTTCCAGGCCTTTCC
TCTTTTTTTCGAGGTTTTTT

Downstream 100 bases:

>100_bases
CTTTACGATTGCCAGATTTAGTCTGGTATGAGTAGTAAAAAGGCCATCAGTTGATGGCCTTTTTAATGTCTAGGTTTTGA
GCGTTATTTTTGCTCGTACA

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFSAFDIFKIGVGPSSSHTVGPMKAAKEFIDDVRQTGQFEQVTRLGVEIFGSLSLTGKGHHTDIAIIVGLGGNSPESVDI
DAIPGFIADVEQTKKLPMGSEKQLVDFGHDAVVFHSHALPLHENGMMLHAYNGDELVLSKTYYSVGGGFIVEESKFGKEV
ENPVAVPYPFNFADELLATCKETGLSISSIMFKNELCFNSEEAIYDGFGAVWATMHQAIEKGCQTEGVLAGPLKVARRAP
ALYRQLLTGERLSSDPMEIVDWINVFAMAVSEENAAGGRVVTSPTNGAAGIIPAVLAYYDKFIKPVGKQDYTRFFLAAAA
VGSLYKRNASISGAEVGCQGEVGVACSMAAAGLAEIMGANPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAAV
KAINSTRMAMRRNCAPKVSLDKVIATMYETGKDMHVKYRETSQGGLAIKVTSICG

Sequences:

>Translated_455_residues
MFSAFDIFKIGVGPSSSHTVGPMKAAKEFIDDVRQTGQFEQVTRLGVEIFGSLSLTGKGHHTDIAIIVGLGGNSPESVDI
DAIPGFIADVEQTKKLPMGSEKQLVDFGHDAVVFHSHALPLHENGMMLHAYNGDELVLSKTYYSVGGGFIVEESKFGKEV
ENPVAVPYPFNFADELLATCKETGLSISSIMFKNELCFNSEEAIYDGFGAVWATMHQAIEKGCQTEGVLAGPLKVARRAP
ALYRQLLTGERLSSDPMEIVDWINVFAMAVSEENAAGGRVVTSPTNGAAGIIPAVLAYYDKFIKPVGKQDYTRFFLAAAA
VGSLYKRNASISGAEVGCQGEVGVACSMAAAGLAEIMGANPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAAV
KAINSTRMAMRRNCAPKVSLDKVIATMYETGKDMHVKYRETSQGGLAIKVTSICG
>Mature_455_residues
MFSAFDIFKIGVGPSSSHTVGPMKAAKEFIDDVRQTGQFEQVTRLGVEIFGSLSLTGKGHHTDIAIIVGLGGNSPESVDI
DAIPGFIADVEQTKKLPMGSEKQLVDFGHDAVVFHSHALPLHENGMMLHAYNGDELVLSKTYYSVGGGFIVEESKFGKEV
ENPVAVPYPFNFADELLATCKETGLSISSIMFKNELCFNSEEAIYDGFGAVWATMHQAIEKGCQTEGVLAGPLKVARRAP
ALYRQLLTGERLSSDPMEIVDWINVFAMAVSEENAAGGRVVTSPTNGAAGIIPAVLAYYDKFIKPVGKQDYTRFFLAAAA
VGSLYKRNASISGAEVGCQGEVGVACSMAAAGLAEIMGANPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAAV
KAINSTRMAMRRNCAPKVSLDKVIATMYETGKDMHVKYRETSQGGLAIKVTSICG

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=451, Percent_Identity=67.8492239467849, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=456, Percent_Identity=64.6929824561403, Blast_Score=607, Evalue=1e-175,
Organism=Escherichia coli, GI1789161, Length=453, Percent_Identity=64.0176600441501, Blast_Score=607, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48535; Mature: 48535

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSAFDIFKIGVGPSSSHTVGPMKAAKEFIDDVRQTGQFEQVTRLGVEIFGSLSLTGKGH
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCC
HTDIAIIVGLGGNSPESVDIDAIPGFIADVEQTKKLPMGSEKQLVDFGHDAVVFHSHALP
CCEEEEEEEECCCCCCCEEHHCCCCHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCC
LHENGMMLHAYNGDELVLSKTYYSVGGGFIVEESKFGKEVENPVAVPYPFNFADELLATC
CCCCCEEEEEECCCEEEEEEEEEECCCCEEEECHHHCHHHCCCEECCCCCCHHHHHHHHH
KETGLSISSIMFKNELCFNSEEAIYDGFGAVWATMHQAIEKGCQTEGVLAGPLKVARRAP
HHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHCH
ALYRQLLTGERLSSDPMEIVDWINVFAMAVSEENAAGGRVVTSPTNGAAGIIPAVLAYYD
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
KFIKPVGKQDYTRFFLAAAAVGSLYKRNASISGAEVGCQGEVGVACSMAAAGLAEIMGAN
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
PEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAAVKAINSTRMAMRRNCAPKVSL
HHHHHHHHHCCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCCHH
DKVIATMYETGKDMHVKYRETSQGGLAIKVTSICG
HHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure
MFSAFDIFKIGVGPSSSHTVGPMKAAKEFIDDVRQTGQFEQVTRLGVEIFGSLSLTGKGH
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCC
HTDIAIIVGLGGNSPESVDIDAIPGFIADVEQTKKLPMGSEKQLVDFGHDAVVFHSHALP
CCEEEEEEEECCCCCCCEEHHCCCCHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCC
LHENGMMLHAYNGDELVLSKTYYSVGGGFIVEESKFGKEVENPVAVPYPFNFADELLATC
CCCCCEEEEEECCCEEEEEEEEEECCCCEEEECHHHCHHHCCCEECCCCCCHHHHHHHHH
KETGLSISSIMFKNELCFNSEEAIYDGFGAVWATMHQAIEKGCQTEGVLAGPLKVARRAP
HHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHCH
ALYRQLLTGERLSSDPMEIVDWINVFAMAVSEENAAGGRVVTSPTNGAAGIIPAVLAYYD
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
KFIKPVGKQDYTRFFLAAAAVGSLYKRNASISGAEVGCQGEVGVACSMAAAGLAEIMGAN
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
PEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAAVKAINSTRMAMRRNCAPKVSL
HHHHHHHHHCCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCCHH
DKVIATMYETGKDMHVKYRETSQGGLAIKVTSICG
HHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]