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The map label for this gene is sdaC [H]

Identifier: 157960599

GI number: 157960599

Start: 956473

End: 957759

Strand: Direct

Name: sdaC [H]

Synonym: Spea_0771

Alternate gene names: 157960599

Gene position: 956473-957759 (Clockwise)

Preceding gene: 157960593

Following gene: 157960600

Centisome position: 18.48

GC content: 43.36

Gene sequence:

>1287_bases
ATGCAAAAAGACGCGATCTGTACAGAAGAAGTGGTACAAAATGATACGGCAACGACTAAGTCAATGCCTTGGACACGTCA
AGATACAACCTGGATGTTGAGTTTGTTTGGTACAGCCGTTGGTGCCGGAATTTTATTCCTACCAATTAACGCTGGTATGG
GCGGTTTTTGGCCGCTAATGATGATGGTTGCTATCATCGGTCCAATGACTTACCTCGCTCACCGTGGCTTGTCGCGTTTT
GTTTGCTCATCAAGCAAGCCAGGCAGTGACATTACTCACGTAGTAGAAGAGCATTTTGGTGTAGGCGCAGGCAAGGCAAT
TACTTTGCTTTATTTCTTCGCTATCTACCCAATCGTTTTAATCTACGGTGTGGGTATTACCAACACTGTTGATAGCTTTA
TTGTAAACCAGTTAGGCATGGCATCGCCACCACGCTTCATTCTATCAGGTGTATTGATCCTTGGTATGATGTCAGTGATG
GTTGCTGGTGAGAAGATGATGCTTAAAGTAACTCAGCTATTGGTATATCCACTAGTGGGCATCTTAGCATTCATGTCTGT
GTATCTTATTCCTGATTGGAAAACAGACGCACTACAAGTTGTGCCAAGCACTGTAGACTTCTTAGGTACGGTTTGGTTGA
CCATCCCAGTACTTATTTTTGCCTTTAACCACTCACCTGCGATTTCACAGTTCTCTGTGTCGCTAAAGCGTGATCACGGT
GCAAATGCAGCACGTAAAGCAGACGTAATCCTACGTAACACCACATTTATGTTGGTTGGTTTCGTGATGATGTTTGTTAT
CTCATGTGTATTAGCACTATCGCCAGCACAGCTTGCTGAAGCGAAATCACTGAACTTGCCAATTCTTTCTTACTTGGCAA
ACGTGCATGAAAGTGGATTTGTAAGCTACTTCGGTCCATTCATTGCCTTCGTTGCGATTATCTCTTCTTTCTTCGGTCAC
TACATGGGTGCTACTGAAGGTATGAAAGGACTAATTACTAAGCAACTACGCTCGAGTGGAAAAGAAGTTTCAGATTCTAA
ACTAAACAAGTTTATTTTAGGTTTCATGTTCTTCACTATCTGGGGCGTGGCAATTATCAACCCAAGCATTTTGGGTATGA
TTGAAGCGCTAGGCGGTCCAATCATCGCTGCGATTCTTTACCTAATGCCAATGTATGCGATTCACAAAGTGCCAGCGCTA
GCTGCATACCGTGGTCGTTTCAGCAACATCTTTGTTGTGATTGCAGGTCTACTTGCAATGACTGCAATTCTGTTTGGTAT
GATGTAA

Upstream 100 bases:

>100_bases
GATCAAGATTTGGCGTATGCATTAGGATATTCTTAACCGCGAAATTACTCACCAAGATCAAAATTAAACGGTGCCACTTA
GCACCTTTAAGGTAACAAAA

Downstream 100 bases:

>100_bases
AAAGATAACGCTAAAAGCTGGGTTGTTTCTTTATGCAGTAGCATATTTGAAATAGCCTGGCTTTTTAACGTTTAAACGCT
TTTTTAAGCGTTAGCCATTA

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MQKDAICTEEVVQNDTATTKSMPWTRQDTTWMLSLFGTAVGAGILFLPINAGMGGFWPLMMMVAIIGPMTYLAHRGLSRF
VCSSSKPGSDITHVVEEHFGVGAGKAITLLYFFAIYPIVLIYGVGITNTVDSFIVNQLGMASPPRFILSGVLILGMMSVM
VAGEKMMLKVTQLLVYPLVGILAFMSVYLIPDWKTDALQVVPSTVDFLGTVWLTIPVLIFAFNHSPAISQFSVSLKRDHG
ANAARKADVILRNTTFMLVGFVMMFVISCVLALSPAQLAEAKSLNLPILSYLANVHESGFVSYFGPFIAFVAIISSFFGH
YMGATEGMKGLITKQLRSSGKEVSDSKLNKFILGFMFFTIWGVAIINPSILGMIEALGGPIIAAILYLMPMYAIHKVPAL
AAYRGRFSNIFVVIAGLLAMTAILFGMM

Sequences:

>Translated_428_residues
MQKDAICTEEVVQNDTATTKSMPWTRQDTTWMLSLFGTAVGAGILFLPINAGMGGFWPLMMMVAIIGPMTYLAHRGLSRF
VCSSSKPGSDITHVVEEHFGVGAGKAITLLYFFAIYPIVLIYGVGITNTVDSFIVNQLGMASPPRFILSGVLILGMMSVM
VAGEKMMLKVTQLLVYPLVGILAFMSVYLIPDWKTDALQVVPSTVDFLGTVWLTIPVLIFAFNHSPAISQFSVSLKRDHG
ANAARKADVILRNTTFMLVGFVMMFVISCVLALSPAQLAEAKSLNLPILSYLANVHESGFVSYFGPFIAFVAIISSFFGH
YMGATEGMKGLITKQLRSSGKEVSDSKLNKFILGFMFFTIWGVAIINPSILGMIEALGGPIIAAILYLMPMYAIHKVPAL
AAYRGRFSNIFVVIAGLLAMTAILFGMM
>Mature_428_residues
MQKDAICTEEVVQNDTATTKSMPWTRQDTTWMLSLFGTAVGAGILFLPINAGMGGFWPLMMMVAIIGPMTYLAHRGLSRF
VCSSSKPGSDITHVVEEHFGVGAGKAITLLYFFAIYPIVLIYGVGITNTVDSFIVNQLGMASPPRFILSGVLILGMMSVM
VAGEKMMLKVTQLLVYPLVGILAFMSVYLIPDWKTDALQVVPSTVDFLGTVWLTIPVLIFAFNHSPAISQFSVSLKRDHG
ANAARKADVILRNTTFMLVGFVMMFVISCVLALSPAQLAEAKSLNLPILSYLANVHESGFVSYFGPFIAFVAIISSFFGH
YMGATEGMKGLITKQLRSSGKEVSDSKLNKFILGFMFFTIWGVAIINPSILGMIEALGGPIIAAILYLMPMYAIHKVPAL
AAYRGRFSNIFVVIAGLLAMTAILFGMM

Specific function: Involved in the import of serine into the cell [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=426, Percent_Identity=53.9906103286385, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1789504, Length=434, Percent_Identity=43.3179723502304, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1789211, Length=408, Percent_Identity=33.3333333333333, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI145693183, Length=416, Percent_Identity=23.5576923076923, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789961, Length=401, Percent_Identity=24.1895261845387, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46487; Mature: 46487

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCC
>Mature Secondary Structure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HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]