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The map label for this gene is tyrP [H]

Identifier: 157960355

GI number: 157960355

Start: 640018

End: 641220

Strand: Direct

Name: tyrP [H]

Synonym: Spea_0526

Alternate gene names: 157960355

Gene position: 640018-641220 (Clockwise)

Preceding gene: 157960352

Following gene: 157960356

Centisome position: 12.37

GC content: 47.05

Gene sequence:

>1203_bases
ATGAACAAAAGTAAAACCTTCGGCAGTATGCTAATCATTGCTGGTACAACCATTGGTGCTGGAATGCTGGCATTGCCTCT
GGCTGCATCGGGTCTTGGCTTTGGTATGGCTAGCATCATCATGCTACTGATTTGGTCACTAATGACCTATACCGCGCTGC
TTATGATTGAAGTACATCAACATGCTCCTATCGATGCGACCTTGCATACCTTGGCGCATAAGCTACTGGGCCGAAAAGGG
CAGCTTATTGCCAGCTTTTCGATGATGTTTCTATTCTACGCACTATGTGCCGCCTACATCGCAGGGGGAGGTGAGCAGAT
CCACAGTAAATTAACTAGCTGGTTTGGACTGGAACTGCCAATGCAGGCTGGAGCAATCATTTTTACCCTATTGATAGGCA
CTGTGGTGGCCATCGGTACTCGCTCGGTGGATCTGATCAACCGCAGCCTGTTTTCACTTAAGCTGATTGCGTTAGTGGTG
ATGCTGTTTCTGCTATTACCCCATGTGTCGGTAGAAAACCTTGTCGAACTGCCTGTTCATCAAGGTTTAGTATTCGCGTC
ACTGCCGGTTATCTTCACCTCTTTTGGTTTTCATGGCTCTATTCCATCGGTTGTACGCTATTTAGGTAAAGATACTAAGG
CGTTACGTTGGATTATTGTTGTGGGCTCTGCATTGCCATTGATGGTATACCTGTTATGGATGCTAGCTAGCCATGGCGTA
TTGCCTCAGGAAGACTTAATGGGCAGCCAAAGCTTGAATGGCTTTATCGCTTCTCTGAGTAGAATGCTAGATAACCCAAT
GATTGCTAACGCGGTATCTATCTTTGCCGACTTAGCCTTAGCGACTTCTTTCCTTGGGGTGAGCCTAGGTCTATTCGACT
TCATCTCAGATCTACTTAAACGCAGCACCAAGGCTAGCCATAGGGTGCAGGTTGGCTTAGTGACCTTCTTACCTCCGCTA
GGCTTTGCTCTGTTCTATCCTCAGGGGTTTATCACCGCATTAGGTTACGCAGCTTTTGCCTTGGTTATTCTGGCTGTTTT
TCTGCCAGTCGCTATGGTTACGGCTCAGCGTAAGCAAGTCGGTTTAGAAGGATACAGAGTCAAAGGCGGAAAGGTAGCCT
TAGTTGCGGCTGGATTAGCTGGAGTGTTGATCATTAGTGTGCAACTGATGCAGATGTTTAATCTACTACCTTCGGTTGGT
TGA

Upstream 100 bases:

>100_bases
GTTTTAAATCACTCCATTGTGGCAATTCCATCTTCTTTCGGAAGTAGGCCACCATCAAAGCCTGTTCCGAACTCAAACTC
ATATATTTGGAACACCATAA

Downstream 100 bases:

>100_bases
TAGGCTGCAGACTAAGAAGTGCTGTTATTTTGATTCGCAATTGACTGAAAAATAGCTGAATAAGCATTATTTTGCATTGT
TGGCTGGTTTTTTAGGCACT

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNKSKTFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQHAPIDATLHTLAHKLLGRKG
QLIASFSMMFLFYALCAAYIAGGGEQIHSKLTSWFGLELPMQAGAIIFTLLIGTVVAIGTRSVDLINRSLFSLKLIALVV
MLFLLLPHVSVENLVELPVHQGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMVYLLWMLASHGV
LPQEDLMGSQSLNGFIASLSRMLDNPMIANAVSIFADLALATSFLGVSLGLFDFISDLLKRSTKASHRVQVGLVTFLPPL
GFALFYPQGFITALGYAAFALVILAVFLPVAMVTAQRKQVGLEGYRVKGGKVALVAAGLAGVLIISVQLMQMFNLLPSVG

Sequences:

>Translated_400_residues
MNKSKTFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQHAPIDATLHTLAHKLLGRKG
QLIASFSMMFLFYALCAAYIAGGGEQIHSKLTSWFGLELPMQAGAIIFTLLIGTVVAIGTRSVDLINRSLFSLKLIALVV
MLFLLLPHVSVENLVELPVHQGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMVYLLWMLASHGV
LPQEDLMGSQSLNGFIASLSRMLDNPMIANAVSIFADLALATSFLGVSLGLFDFISDLLKRSTKASHRVQVGLVTFLPPL
GFALFYPQGFITALGYAAFALVILAVFLPVAMVTAQRKQVGLEGYRVKGGKVALVAAGLAGVLIISVQLMQMFNLLPSVG
>Mature_400_residues
MNKSKTFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQHAPIDATLHTLAHKLLGRKG
QLIASFSMMFLFYALCAAYIAGGGEQIHSKLTSWFGLELPMQAGAIIFTLLIGTVVAIGTRSVDLINRSLFSLKLIALVV
MLFLLLPHVSVENLVELPVHQGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMVYLLWMLASHGV
LPQEDLMGSQSLNGFIASLSRMLDNPMIANAVSIFADLALATSFLGVSLGLFDFISDLLKRSTKASHRVQVGLVTFLPPL
GFALFYPQGFITALGYAAFALVILAVFLPVAMVTAQRKQVGLEGYRVKGGKVALVAAGLAGVLIISVQLMQMFNLLPSVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=402, Percent_Identity=52.4875621890547, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1789552, Length=384, Percent_Identity=31.25, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1790145, Length=409, Percent_Identity=30.0733496332518, Blast_Score=196, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42765; Mature: 42765

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS00589 PTS_HPR_SER ; PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSKTFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQ
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
HAPIDATLHTLAHKLLGRKGQLIASFSMMFLFYALCAAYIAGGGEQIHSKLTSWFGLELP
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
MQAGAIIFTLLIGTVVAIGTRSVDLINRSLFSLKLIALVVMLFLLLPHVSVENLVELPVH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMVYLLWMLASHGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
LPQEDLMGSQSLNGFIASLSRMLDNPMIANAVSIFADLALATSFLGVSLGLFDFISDLLK
CCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSTKASHRVQVGLVTFLPPLGFALFYPQGFITALGYAAFALVILAVFLPVAMVTAQRKQV
HHHCHHHHEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLEGYRVKGGKVALVAAGLAGVLIISVQLMQMFNLLPSVG
CCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKSKTFGSMLIIAGTTIGAGMLALPLAASGLGFGMASIIMLLIWSLMTYTALLMIEVHQ
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
HAPIDATLHTLAHKLLGRKGQLIASFSMMFLFYALCAAYIAGGGEQIHSKLTSWFGLELP
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
MQAGAIIFTLLIGTVVAIGTRSVDLINRSLFSLKLIALVVMLFLLLPHVSVENLVELPVH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QGLVFASLPVIFTSFGFHGSIPSVVRYLGKDTKALRWIIVVGSALPLMVYLLWMLASHGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
LPQEDLMGSQSLNGFIASLSRMLDNPMIANAVSIFADLALATSFLGVSLGLFDFISDLLK
CCHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSTKASHRVQVGLVTFLPPLGFALFYPQGFITALGYAAFALVILAVFLPVAMVTAQRKQV
HHHCHHHHEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLEGYRVKGGKVALVAAGLAGVLIISVQLMQMFNLLPSVG
CCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]