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The map label for this gene is fkpA [H]

Identifier: 157960334

GI number: 157960334

Start: 619233

End: 620018

Strand: Direct

Name: fkpA [H]

Synonym: Spea_0505

Alternate gene names: 157960334

Gene position: 619233-620018 (Clockwise)

Preceding gene: 157960333

Following gene: 157960335

Centisome position: 11.97

GC content: 44.66

Gene sequence:

>786_bases
ATGAAAATATTTACAAAAACTACCCTAGCTGTTGTGACAAGTTTCACTCTATTTATGTCAGCCAACTCAATGGCCGCAAC
CGAGCTGACTTCTGATGTGCAAAAAGAGTCTTACAGTATCGGTGCTTCTTTAGGTAAATACATCTCGGGCCAAATTTATA
GCCAAACTGAGTTGGGTGCTGAAGTCGATGTAGACCTTGTCATTGAAGGTGTGGTGGATGCTCTTAAAAATAACTCACAG
TTTTCAGATGAAGAAATTCTCACCTATTTAAATCAGCGTGCAGAGCAGTTAAATACAGCTCGCGAAGCTGCAGAGGCCAA
AATTGCCTTAGCAAACCTTACAGCGGGTAATAAGTATTTAGCAGAAAACGAAAAGAAAGATGGCGTTATGGTCACCGAGT
CTGGTCTGCAGTATGAAGTGATTAGCGAAGGGAAAGGCCGTAAGCCAAACCCACAAGATGTGGTAACTGTGCACTATAAA
GGTTTCCTTATCGACGGCACAGAGTTTGATGACTCACACAAGCGCAATGAGCCAAATCGCTTTGCATTAATGAGCGTGAT
TGAAGGCTGGCAAGAAGGCATTCCGTTGATGAAAGAAGGTTCAACTTACAAGTTTGCCATTCCTGCAGCGCTGGCCTACG
GCGAAAAGCAAGTCGGTATTATTCCGCCAAGCTCTACTCTAGTTTTTGAAGTTGAGCTAGTTAAAGTTGAAGCTCCTGGC
CAAAACTCACACGGCATGGGCCTTAGTGGTATGGGCATGGGCGGTATGATGGGCGGCGGTCACTAA

Upstream 100 bases:

>100_bases
ACGGATGGCGCTTGGCAAACCGTGTAACGGAAAGACCATAACAGCTGGATGTTGGGTATAAAAATTACGTAAAACTAATT
TATTCAAAGAGATAACCATT

Downstream 100 bases:

>100_bases
TCGCTGCTGCTAGCAAATTAATTTAGCTAGTGTTTATTAAGTTTTAAGTTGTTGTTTTAGTAAGTTTCGTTTGTAGAGAG
TCACTATGAATAGTTTAGCT

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKIFTKTTLAVVTSFTLFMSANSMAATELTSDVQKESYSIGASLGKYISGQIYSQTELGAEVDVDLVIEGVVDALKNNSQ
FSDEEILTYLNQRAEQLNTAREAAEAKIALANLTAGNKYLAENEKKDGVMVTESGLQYEVISEGKGRKPNPQDVVTVHYK
GFLIDGTEFDDSHKRNEPNRFALMSVIEGWQEGIPLMKEGSTYKFAIPAALAYGEKQVGIIPPSSTLVFEVELVKVEAPG
QNSHGMGLSGMGMGGMMGGGH

Sequences:

>Translated_261_residues
MKIFTKTTLAVVTSFTLFMSANSMAATELTSDVQKESYSIGASLGKYISGQIYSQTELGAEVDVDLVIEGVVDALKNNSQ
FSDEEILTYLNQRAEQLNTAREAAEAKIALANLTAGNKYLAENEKKDGVMVTESGLQYEVISEGKGRKPNPQDVVTVHYK
GFLIDGTEFDDSHKRNEPNRFALMSVIEGWQEGIPLMKEGSTYKFAIPAALAYGEKQVGIIPPSSTLVFEVELVKVEAPG
QNSHGMGLSGMGMGGMMGGGH
>Mature_261_residues
MKIFTKTTLAVVTSFTLFMSANSMAATELTSDVQKESYSIGASLGKYISGQIYSQTELGAEVDVDLVIEGVVDALKNNSQ
FSDEEILTYLNQRAEQLNTAREAAEAKIALANLTAGNKYLAENEKKDGVMVTESGLQYEVISEGKGRKPNPQDVVTVHYK
GFLIDGTEFDDSHKRNEPNRFALMSVIEGWQEGIPLMKEGSTYKFAIPAALAYGEKQVGIIPPSSTLVFEVELVKVEAPG
QNSHGMGLSGMGMGGMMGGGH

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=47.6635514018692, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=47.6635514018692, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI206725530, Length=88, Percent_Identity=50, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI17149844, Length=88, Percent_Identity=50, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI17149842, Length=88, Percent_Identity=50, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI8923659, Length=124, Percent_Identity=36.2903225806452, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789745, Length=217, Percent_Identity=42.3963133640553, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=42.2330097087379, Blast_Score=134, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17540882, Length=126, Percent_Identity=37.3015873015873, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=95, Percent_Identity=49.4736842105263, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=42.7272727272727, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=44.8598130841121, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356629, Length=99, Percent_Identity=48.4848484848485, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281363946, Length=113, Percent_Identity=40.7079646017699, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17352457, Length=113, Percent_Identity=40.7079646017699, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=38.6792452830189, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28161; Mature: 28161

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFTKTTLAVVTSFTLFMSANSMAATELTSDVQKESYSIGASLGKYISGQIYSQTELGA
CCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCC
EVDVDLVIEGVVDALKNNSQFSDEEILTYLNQRAEQLNTAREAAEAKIALANLTAGNKYL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEE
AENEKKDGVMVTESGLQYEVISEGKGRKPNPQDVVTVHYKGFLIDGTEFDDSHKRNEPNR
CCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHH
FALMSVIEGWQEGIPLMKEGSTYKFAIPAALAYGEKQVGIIPPSSTLVFEVELVKVEAPG
HHHHHHHHHHHHCCCEEECCCEEEEECCHHHHCCCCEEEEECCCCEEEEEEEEEEEECCC
QNSHGMGLSGMGMGGMMGGGH
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIFTKTTLAVVTSFTLFMSANSMAATELTSDVQKESYSIGASLGKYISGQIYSQTELGA
CCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCC
EVDVDLVIEGVVDALKNNSQFSDEEILTYLNQRAEQLNTAREAAEAKIALANLTAGNKYL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEE
AENEKKDGVMVTESGLQYEVISEGKGRKPNPQDVVTVHYKGFLIDGTEFDDSHKRNEPNR
CCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHH
FALMSVIEGWQEGIPLMKEGSTYKFAIPAALAYGEKQVGIIPPSSTLVFEVELVKVEAPG
HHHHHHHHHHHHCCCEEECCCEEEEECCHHHHCCCCEEEEECCCCEEEEEEEEEEEECCC
QNSHGMGLSGMGMGGMMGGGH
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]