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The map label for this gene is fkpA [H]

Identifier: 157960310

GI number: 157960310

Start: 592614

End: 593417

Strand: Direct

Name: fkpA [H]

Synonym: Spea_0481

Alternate gene names: 157960310

Gene position: 592614-593417 (Clockwise)

Preceding gene: 157960309

Following gene: 157960311

Centisome position: 11.45

GC content: 46.39

Gene sequence:

>804_bases
ATGAAAAAGCTTAAAAAAAGTGTCTTGGCCGTTGTGTCTTGTCTAACCCTATCAGTATCAGCGTCGTGTTTTGCTAATAG
CGACCTCACCACTGACGTTGAAAAGGAGTCGTACAGTATAGGTGCGTCATTTGGTCACCATATCTCTAGTCAGGTATATG
GCCAAACTCAGCTCGGCGCAGAAGTCGATATGGGGCAAGTTGTAAACGGTTTACTCGATGCGTTACAAGACGAAACAAAA
ATGTCTAAAGAGGAAATCGTGACTTACCTTAATCAGCGCGCAGAGACGTTAAATGCGGCTAAGCAGGTCAAGTTAGATGC
ACTCACTGCTAAGAATCTAGCAGCGGGTGAAGCTTTCATGGCTGAAAATGCTAAAAACAGTGGCGTTAAACAGACCGAGT
CAGGACTGCAGTATGAAGTGATCACCCTAGGTGAAGGCACAATGCCGCAAGGCAACGATGTTGTTACCGTTCACTACAAG
GGCACCTTGATTGATGGCACTGAGTTTGACAGCACTTATGACCGTGACGAACCAAACCGTTTCTCTTTAGTTACCGTTAT
TGAAGGCTGGCAAGAAGCTCTTGCACTAATGCCTCAAGGGTCAAAATTTAAGTTAACGATTCCACCTGCACTCGCTTACG
GTGACCGTGTTGTTGGCATGATTCAGCCTCACTCTACTTTGGTATTTGAAGTTGAATTAGTCAAAGTTGAAGCGCCTGGT
GAAGGTGCTCACGGCATGGGACTAAGTGGCATGGGTATGGGTGGCATGATGGGCGGCTCTATGGGCGCCAATCCACACAA
TTAA

Upstream 100 bases:

>100_bases
CGTCAAATGCCAGATGGAATTTACGGCTGGCGTTTATCGAATCGAGTAACAGAAAAGCCATAACGGATTATGTTTATTTA
TTTTTAGTGAGATTGATTGT

Downstream 100 bases:

>100_bases
ATTTAATATTAATTATTGATATAGAGCCAAGATGAATACATTGCTACTCAGTATTTCAGCTATCTTATTTTGTTCGTTTG
CATTGCTTGTTTGCCATCAC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKKLKKSVLAVVSCLTLSVSASCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGAEVDMGQVVNGLLDALQDETK
MSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFMAENAKNSGVKQTESGLQYEVITLGEGTMPQGNDVVTVHYK
GTLIDGTEFDSTYDRDEPNRFSLVTVIEGWQEALALMPQGSKFKLTIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EGAHGMGLSGMGMGGMMGGSMGANPHN

Sequences:

>Translated_267_residues
MKKLKKSVLAVVSCLTLSVSASCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGAEVDMGQVVNGLLDALQDETK
MSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFMAENAKNSGVKQTESGLQYEVITLGEGTMPQGNDVVTVHYK
GTLIDGTEFDSTYDRDEPNRFSLVTVIEGWQEALALMPQGSKFKLTIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EGAHGMGLSGMGMGGMMGGSMGANPHN
>Mature_267_residues
MKKLKKSVLAVVSCLTLSVSASCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGAEVDMGQVVNGLLDALQDETK
MSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFMAENAKNSGVKQTESGLQYEVITLGEGTMPQGNDVVTVHYK
GTLIDGTEFDSTYDRDEPNRFSLVTVIEGWQEALALMPQGSKFKLTIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EGAHGMGLSGMGMGGMMGGSMGANPHN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=48.5981308411215, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=48.5981308411215, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=41.1214953271028, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI206725530, Length=88, Percent_Identity=51.1363636363636, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI17149844, Length=88, Percent_Identity=51.1363636363636, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI17149842, Length=88, Percent_Identity=51.1363636363636, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503729, Length=97, Percent_Identity=45.360824742268, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=41.304347826087, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI192448443, Length=95, Percent_Identity=40, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4503727, Length=170, Percent_Identity=31.7647058823529, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=41.743119266055, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI87082390, Length=202, Percent_Identity=45.049504950495, Blast_Score=147, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=46.7391304347826, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=41.5094339622642, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=108, Percent_Identity=44.4444444444444, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320727, Length=95, Percent_Identity=50.5263157894737, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=48.5981308411215, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281363946, Length=107, Percent_Identity=46.7289719626168, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17352457, Length=107, Percent_Identity=46.7289719626168, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356629, Length=92, Percent_Identity=50, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=40.5660377358491, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28413; Mature: 28413

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLKKSVLAVVSCLTLSVSASCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHCCC
EVDMGQVVNGLLDALQDETKMSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFM
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHH
AENAKNSGVKQTESGLQYEVITLGEGTMPQGNDVVTVHYKGTLIDGTEFDSTYDRDEPNR
HCCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCCC
FSLVTVIEGWQEALALMPQGSKFKLTIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEEEECCCCEEEEEEEEEEEECCC
EGAHGMGLSGMGMGGMMGGSMGANPHN
CCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLKKSVLAVVSCLTLSVSASCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHCCC
EVDMGQVVNGLLDALQDETKMSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFM
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHH
AENAKNSGVKQTESGLQYEVITLGEGTMPQGNDVVTVHYKGTLIDGTEFDSTYDRDEPNR
HCCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCCC
FSLVTVIEGWQEALALMPQGSKFKLTIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEEEECCCCEEEEEEEEEEEECCC
EGAHGMGLSGMGMGGMMGGSMGANPHN
CCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]