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The map label for this gene is neuC [H]

Identifier: 157959878

GI number: 157959878

Start: 64064

End: 65242

Strand: Direct

Name: neuC [H]

Synonym: Spea_0048

Alternate gene names: 157959878

Gene position: 64064-65242 (Clockwise)

Preceding gene: 157959877

Following gene: 157959879

Centisome position: 1.24

GC content: 40.63

Gene sequence:

>1179_bases
ATGACGCAGATGCATAAAAAAGTTGCGGTTTTTACAGGGACAAGAGCTGAGTATGGTCTGCTCTATTGGCTTTTAAAGGA
CATACAAAGCGATCCCGAGTTGACACTTCAATTGTTAGTATCTGGCATGCACTTTTCTCCAGAGTTTGGAGAGACCTATA
AAGATATAGAGAAAGATGGTTTCAATATTGATGAAAAAATTGAAATCTTATTATCGTCTGACTCGCCGGTAGGAACAGCA
AAAAGTATAGGGCTCGGTGTTCTTGGCTTTGCTGATGCACTAGCGCGATTACGACCAGATGTATTGATTATCCTAGGTGA
CCGTTTTGAAGCCCTTGCAGCCGCTCAGACTGCGATGATACTGCGTATACCAATTGTGCACCTTCATGGTGGTGAAATAA
CAGAAGGTGCTTATGATGATGCGATTCGTCATGCTATTACTAAGTTGAGTTACCTTCATGGAACTTCAACTGAAGACTAT
CGAAATCGAGTTATTCAGTTAGGAGAGGCGCCAGAACGAGTAAAAAACATTGGTGCAATCGGATTAGACCATCTGAACCG
AGCGTCATTTATGACTGTATCAGAGTTGAGCAAATCACTCTGTTTTGAGCTAAATAGACCATATTTTGTAGTTACTTATC
ATCCGGTAACACTAGGGGAAGAAGCTCCTGAAGCGACTTTTCAGGCAATACTAGATGCATTAGATGAATACTCTGAATAC
CAAGTTATATTGACTTACCCAAATGCTGATGATGGTGGGCGACGAATTATTCCGATGTTAAAAGCGTATGCATTAAGTCA
ACCCAGTCGAGTATTGGCTATTCCTTCTCTTGGGCAAGTTCGTTACTTGAGTGCAGTAAAGCATGCTGCAGCCGTAATTG
GTAACTCATCGAGCGGAATTATAGAGGTTCCCGCATTTGATATTGCAACGGTAAATATTGGTGTAAGACAAAAAGGACGC
TTGGCGGCTAAAAGTGTATTGAATGCACAACCGAATCAACATTCAATTTCTGAACAAATTCAAATTGCAGTTAGGCGCAG
TTATAAGCAAATTGATGAGAAGATTTGCAACCCTTACGGGCAGGGAAATGCGAGCAAACAAGTTATTGAAATGATAAAAA
CACTTTCATTTGAACCAAGTAAAGTGTTCTTCGATATCAACTTTTCTTGCCAACAGTGA

Upstream 100 bases:

>100_bases
TGCGTGGTGATCTCTCCTGCTCAGAGTTTGTCGAAGCTCATTTAATAAATCTTCCAAGTACACCCGTTGTACTAAATACC
TCGCAGGGATAACTAGAATC

Downstream 100 bases:

>100_bases
GGTCATCATGACGCTAATTATTGCAGAAGCTGGTGTGAATCATAACGGTGACGAGAAATTGGCTTTTGAATTAGTCAGTG
CGGCGCATCAGGCGGGTGCT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTQMHKKVAVFTGTRAEYGLLYWLLKDIQSDPELTLQLLVSGMHFSPEFGETYKDIEKDGFNIDEKIEILLSSDSPVGTA
KSIGLGVLGFADALARLRPDVLIILGDRFEALAAAQTAMILRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEDY
RNRVIQLGEAPERVKNIGAIGLDHLNRASFMTVSELSKSLCFELNRPYFVVTYHPVTLGEEAPEATFQAILDALDEYSEY
QVILTYPNADDGGRRIIPMLKAYALSQPSRVLAIPSLGQVRYLSAVKHAAAVIGNSSSGIIEVPAFDIATVNIGVRQKGR
LAAKSVLNAQPNQHSISEQIQIAVRRSYKQIDEKICNPYGQGNASKQVIEMIKTLSFEPSKVFFDINFSCQQ

Sequences:

>Translated_392_residues
MTQMHKKVAVFTGTRAEYGLLYWLLKDIQSDPELTLQLLVSGMHFSPEFGETYKDIEKDGFNIDEKIEILLSSDSPVGTA
KSIGLGVLGFADALARLRPDVLIILGDRFEALAAAQTAMILRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEDY
RNRVIQLGEAPERVKNIGAIGLDHLNRASFMTVSELSKSLCFELNRPYFVVTYHPVTLGEEAPEATFQAILDALDEYSEY
QVILTYPNADDGGRRIIPMLKAYALSQPSRVLAIPSLGQVRYLSAVKHAAAVIGNSSSGIIEVPAFDIATVNIGVRQKGR
LAAKSVLNAQPNQHSISEQIQIAVRRSYKQIDEKICNPYGQGNASKQVIEMIKTLSFEPSKVFFDINFSCQQ
>Mature_391_residues
TQMHKKVAVFTGTRAEYGLLYWLLKDIQSDPELTLQLLVSGMHFSPEFGETYKDIEKDGFNIDEKIEILLSSDSPVGTAK
SIGLGVLGFADALARLRPDVLIILGDRFEALAAAQTAMILRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEDYR
NRVIQLGEAPERVKNIGAIGLDHLNRASFMTVSELSKSLCFELNRPYFVVTYHPVTLGEEAPEATFQAILDALDEYSEYQ
VILTYPNADDGGRRIIPMLKAYALSQPSRVLAIPSLGQVRYLSAVKHAAAVIGNSSSGIIEVPAFDIATVNIGVRQKGRL
AAKSVLNAQPNQHSISEQIQIAVRRSYKQIDEKICNPYGQGNASKQVIEMIKTLSFEPSKVFFDINFSCQQ

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=379, Percent_Identity=30.6068601583113, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4885285, Length=379, Percent_Identity=30.6068601583113, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI190014632, Length=379, Percent_Identity=30.6068601583113, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI298566325, Length=347, Percent_Identity=29.6829971181556, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI298566315, Length=326, Percent_Identity=26.0736196319018, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 43257; Mature: 43126

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQMHKKVAVFTGTRAEYGLLYWLLKDIQSDPELTLQLLVSGMHFSPEFGETYKDIEKDG
CCCHHCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
FNIDEKIEILLSSDSPVGTAKSIGLGVLGFADALARLRPDVLIILGDRFEALAAAQTAMI
CCCCCEEEEEEECCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHEEE
LRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEDYRNRVIQLGEAPERVKNIGAI
EEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHEECCCCHHHHHHCCCC
GLDHLNRASFMTVSELSKSLCFELNRPYFVVTYHPVTLGEEAPEATFQAILDALDEYSEY
CHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCHHHHHHHHHHHHHCCCCE
QVILTYPNADDGGRRIIPMLKAYALSQPSRVLAIPSLGQVRYLSAVKHAAAVIGNSSSGI
EEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCE
IEVPAFDIATVNIGVRQKGRLAAKSVLNAQPNQHSISEQIQIAVRRSYKQIDEKICNPYG
EEECCEEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
QGNASKQVIEMIKTLSFEPSKVFFDINFSCQQ
CCCHHHHHHHHHHHCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
TQMHKKVAVFTGTRAEYGLLYWLLKDIQSDPELTLQLLVSGMHFSPEFGETYKDIEKDG
CCHHCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCC
FNIDEKIEILLSSDSPVGTAKSIGLGVLGFADALARLRPDVLIILGDRFEALAAAQTAMI
CCCCCEEEEEEECCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHEEE
LRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEDYRNRVIQLGEAPERVKNIGAI
EEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHEECCCCHHHHHHCCCC
GLDHLNRASFMTVSELSKSLCFELNRPYFVVTYHPVTLGEEAPEATFQAILDALDEYSEY
CHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCHHHHHHHHHHHHHCCCCE
QVILTYPNADDGGRRIIPMLKAYALSQPSRVLAIPSLGQVRYLSAVKHAAAVIGNSSSGI
EEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCE
IEVPAFDIATVNIGVRQKGRLAAKSVLNAQPNQHSISEQIQIAVRRSYKQIDEKICNPYG
EEECCEEEEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
QGNASKQVIEMIKTLSFEPSKVFFDINFSCQQ
CCCHHHHHHHHHHHCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]