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The map label for this gene is pepQ [H]

Identifier: 157959849

GI number: 157959849

Start: 22709

End: 24031

Strand: Direct

Name: pepQ [H]

Synonym: Spea_0019

Alternate gene names: 157959849

Gene position: 22709-24031 (Clockwise)

Preceding gene: 157959838

Following gene: 157959850

Centisome position: 0.44

GC content: 44.9

Gene sequence:

>1323_bases
ATGGAACAGTTAGCGCGCCTCTATCATGACCATATTCAAGTGCTTAATCAGCGTGTCAGCGAAATCATTTCTCGTGAAAA
CTTATCGGGTCTCGTCATCCATTCAGGTCAGCCACATAGACAGTTTTTAGATGATATGGATTACCCATTTAAGGTGAACC
CACACTTTAAAGCTTGGTTGCCGGTCATCGAAAACCCAAATTCATGGTTGGTGATAAACGGCAGTGATAAGCCCCTATTG
ATTTTTTATCGCCCGGTAGATTTTTGGCACAAGGTTGCCGATGAGCCGAGTGACTTTTGGGCCGAGCATGTCGACATCAA
GTTTCTAACTAAGGCCGACAAAGTAGCCGAATATCTGCCAGCGGGTATCGATAATTGGGCCTATATTGGTGAGCATTTAG
ATGTTGCCGATGTGCTGGGTTTTAGCAGGCGTAATCCTGATTCAGTATTGAGCTATCTCAACTATCACCGCGCGACCAAA
ACCGATTATGAGTTAGCCTGTATGCGTAAAGCTAATGAAATAGCGGTGACCGGGCATCAAGCGGCTAAAACAGCATTCTA
TAATGGTGCGAGTGAATTTGAGATCCTACAGGTCTATCTGTCGGCAATCTCACAAGGTGAAAACCAAGTCCCCTATAGCA
GCATCGTTGCGCTAAATGAAAACTCCGCCATCTTACATTACACCGCGCTTGAATATACGAGCCCAGCGCAGCGGCGTTCA
TTCTTGATCGACGCAGGCGCTAACTATAATGGTTATGCCTCCGATATTACCCGTAGCTATTCATTTGAGAAGAACATCTT
CGATGATCTGATCACCGCAATGGACAATATGCAGCTACAGATCATAAGCATGATGAAGCCTGGTGTGAGCTATGCTGAAT
TACACATACAAACTCATTATAAGCTAGCGCAGATCTTGCTGGATTTTGATATTGTCAGCGGCGATGTTCAGGGCCTTGTC
GAACAGGGAATTACTCGAGTCTTTTTCCCCCATGGTTTAGGCCATATGTTAGGCATACAAGTGCACGATATGGGAGGTTT
CCTCAGCGATGAAAAGGGCACTCATGTCGCAGCACCTGAGGCACATCCATTCTTACGTTGTACTCGAGAACTTGATATCA
ACCAAGTACTGACGATAGAGCCGGGTGTTTATATTATCGATTCGCTACTCGCAGAGTTAAAACAGGATCAGAGGCAATCA
CAGATCAATTGGAATACCGTTGATGTCTTAAGGCCGTTTGGTGGTATTCGCATCGAAGATAATGTAATTGTTCATGGCGA
TCGTATCGAGAATATGACCCGTAATTTGGGTTTGAATCGTTAA

Upstream 100 bases:

>100_bases
AAAAAGGAATAATGAGTTTGAAGAAAAAATTTTTTTAGCGATGTGATAGACTGAACCGATGTCGAAAATTTGGCTAAATA
ATAACAATAGGGTAACCCTC

Downstream 100 bases:

>100_bases
CCTAATGAGAGAAGCGTTTTGAGTGAGAGTTATCTCATCCCTGCAGCGGAATTATTGATAGAAGAAGAGATAAAGCATAG
TCGCTTTATCTCTTTTCTAT

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MEQLARLYHDHIQVLNQRVSEIISRENLSGLVIHSGQPHRQFLDDMDYPFKVNPHFKAWLPVIENPNSWLVINGSDKPLL
IFYRPVDFWHKVADEPSDFWAEHVDIKFLTKADKVAEYLPAGIDNWAYIGEHLDVADVLGFSRRNPDSVLSYLNYHRATK
TDYELACMRKANEIAVTGHQAAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEYTSPAQRRS
FLIDAGANYNGYASDITRSYSFEKNIFDDLITAMDNMQLQIISMMKPGVSYAELHIQTHYKLAQILLDFDIVSGDVQGLV
EQGITRVFFPHGLGHMLGIQVHDMGGFLSDEKGTHVAAPEAHPFLRCTRELDINQVLTIEPGVYIIDSLLAELKQDQRQS
QINWNTVDVLRPFGGIRIEDNVIVHGDRIENMTRNLGLNR

Sequences:

>Translated_440_residues
MEQLARLYHDHIQVLNQRVSEIISRENLSGLVIHSGQPHRQFLDDMDYPFKVNPHFKAWLPVIENPNSWLVINGSDKPLL
IFYRPVDFWHKVADEPSDFWAEHVDIKFLTKADKVAEYLPAGIDNWAYIGEHLDVADVLGFSRRNPDSVLSYLNYHRATK
TDYELACMRKANEIAVTGHQAAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEYTSPAQRRS
FLIDAGANYNGYASDITRSYSFEKNIFDDLITAMDNMQLQIISMMKPGVSYAELHIQTHYKLAQILLDFDIVSGDVQGLV
EQGITRVFFPHGLGHMLGIQVHDMGGFLSDEKGTHVAAPEAHPFLRCTRELDINQVLTIEPGVYIIDSLLAELKQDQRQS
QINWNTVDVLRPFGGIRIEDNVIVHGDRIENMTRNLGLNR
>Mature_440_residues
MEQLARLYHDHIQVLNQRVSEIISRENLSGLVIHSGQPHRQFLDDMDYPFKVNPHFKAWLPVIENPNSWLVINGSDKPLL
IFYRPVDFWHKVADEPSDFWAEHVDIKFLTKADKVAEYLPAGIDNWAYIGEHLDVADVLGFSRRNPDSVLSYLNYHRATK
TDYELACMRKANEIAVTGHQAAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEYTSPAQRRS
FLIDAGANYNGYASDITRSYSFEKNIFDDLITAMDNMQLQIISMMKPGVSYAELHIQTHYKLAQILLDFDIVSGDVQGLV
EQGITRVFFPHGLGHMLGIQVHDMGGFLSDEKGTHVAAPEAHPFLRCTRELDINQVLTIEPGVYIIDSLLAELKQDQRQS
QINWNTVDVLRPFGGIRIEDNVIVHGDRIENMTRNLGLNR

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=293, Percent_Identity=34.4709897610922, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI260593665, Length=288, Percent_Identity=34.375, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI260593663, Length=435, Percent_Identity=28.5057471264368, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI1790282, Length=442, Percent_Identity=50.2262443438914, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789275, Length=291, Percent_Identity=29.8969072164948, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17508215, Length=354, Percent_Identity=31.3559322033898, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321118, Length=287, Percent_Identity=32.404181184669, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=286, Percent_Identity=28.3216783216783, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357079, Length=463, Percent_Identity=26.5658747300216, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI19920384, Length=285, Percent_Identity=28.0701754385965, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 49988; Mature: 49988

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLARLYHDHIQVLNQRVSEIISRENLSGLVIHSGQPHRQFLDDMDYPFKVNPHFKAWL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCEEECCCCEEEE
PVIENPNSWLVINGSDKPLLIFYRPVDFWHKVADEPSDFWAEHVDIKFLTKADKVAEYLP
EEEECCCCEEEEECCCCEEEEEECCHHHHHHHHCCCHHHHHHHCCEEEEHHHHHHHHHHC
AGIDNWAYIGEHLDVADVLGFSRRNPDSVLSYLNYHRATKTDYELACMRKANEIAVTGHQ
CCCCCHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCH
AAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEYTSPAQRRS
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCEEEEEEEECCCCCHHHCE
FLIDAGANYNGYASDITRSYSFEKNIFDDLITAMDNMQLQIISMMKPGVSYAELHIQTHY
EEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEEHHHH
KLAQILLDFDIVSGDVQGLVEQGITRVFFPHGLGHMLGIQVHDMGGFLSDEKGTHVAAPE
HHHHHHHHHHHHCHHHHHHHHHCCCEEECCCCCCHHEEEEEECCCCCCCCCCCCEEECCC
AHPFLRCTRELDINQVLTIEPGVYIIDSLLAELKQDQRQSQINWNTVDVLRPFGGIRIED
CCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEC
NVIVHGDRIENMTRNLGLNR
CEEEECHHHHHHHHHCCCCC
>Mature Secondary Structure
MEQLARLYHDHIQVLNQRVSEIISRENLSGLVIHSGQPHRQFLDDMDYPFKVNPHFKAWL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCEEECCCCEEEE
PVIENPNSWLVINGSDKPLLIFYRPVDFWHKVADEPSDFWAEHVDIKFLTKADKVAEYLP
EEEECCCCEEEEECCCCEEEEEECCHHHHHHHHCCCHHHHHHHCCEEEEHHHHHHHHHHC
AGIDNWAYIGEHLDVADVLGFSRRNPDSVLSYLNYHRATKTDYELACMRKANEIAVTGHQ
CCCCCHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCH
AAKTAFYNGASEFEILQVYLSAISQGENQVPYSSIVALNENSAILHYTALEYTSPAQRRS
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCEEEEEEEECCCCCHHHCE
FLIDAGANYNGYASDITRSYSFEKNIFDDLITAMDNMQLQIISMMKPGVSYAELHIQTHY
EEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEEHHHH
KLAQILLDFDIVSGDVQGLVEQGITRVFFPHGLGHMLGIQVHDMGGFLSDEKGTHVAAPE
HHHHHHHHHHHHCHHHHHHHHHCCCEEECCCCCCHHEEEEEECCCCCCCCCCCCEEECCC
AHPFLRCTRELDINQVLTIEPGVYIIDSLLAELKQDQRQSQINWNTVDVLRPFGGIRIED
CCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEC
NVIVHGDRIENMTRNLGLNR
CEEEECHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA