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The map label for this gene is hemE

Identifier: 157826384

GI number: 157826384

Start: 1229658

End: 1230674

Strand: Reverse

Name: hemE

Synonym: A1C_06880

Alternate gene names: 157826384

Gene position: 1230674-1229658 (Counterclockwise)

Preceding gene: NA

Following gene: 157826383

Centisome position: 99.97

GC content: 28.61

Gene sequence:

>1017_bases
ATGAATCAAATTTCAAATCCGTTGAAAGGAAATAATAATAAAATACCTATTTGGTTTATGCGTCAAGCAGGCAGATATCT
GTCAGAATATAAAAAAGTAAGAGAAACAACAAAAAATTTTCTAGATTTTTGTTATGATGTTAACAAAGCAACGGAAGTAA
CATTACAACCGATAAAACGTTATGGATTCGATGCAGCTATTATTTTTTCTGATATATTAGTTTTACCTCATGCTTTTGGA
TGGGAAATAGATTTTAAAGAAAATATAGGACCTATATTAAAGCAGTTTAAATCACAAGAAGATTTTAAATATCTACAAAG
CAATCCGAATAATAAATTAGGGAAAGTTTACGAAATAATAAAAAAAGTAAAAGCAGACTTAACTTCCACCACTTCTTTAA
TAGGATTTGCAGGTAGTCCTTGGACAGTTATGAGTTATATGCTAGAAGGAAAAGGAAAACATGATTTTAAAACGAGCAAA
AAATTTATATATGAAAATAAAATACTTGCTAAAGAATTATTAAATTTTATTACGGAAAAAACAGCTGATCATCTTATAAA
TCAGGCAAAATCTGGGGCAGATGTCTTAAAGCTTTTCGATTCATGGTCAGGAGTACTTCCAGAAGATGAGTTTACTAAAT
TTGTAATAGAGCCGACAAAAAAGATTATACTGAAAGTAAAAGAAGTTTTTCCAAAAATTCCTATGATTGCTTTTCCTAAA
GGAGCTGGATTATTGTACGAAAAATTTATAAAAGAAGTACCAGTAGATATTTTAGCTGTAGATCAAATGGTCCCTCTTGA
AAAAATGAAAAAGTGGAGTGACAAGGTAATAGTACAAGGTAATTTAGATCCTGTTGTATTATTAACTAATAAAGAAATTA
TCAAAGAAAAAGCTTATAAAATTATTCAGGAAATGAAAGGAAAGAATTTTATCTTTAATTTAGGACATGGTATTTTGCCT
AAAACACCTCCGGAAAATGTAGAATTTTTAACAGAGTGTATTAGGTCTTGTGAATAA

Upstream 100 bases:

>100_bases
ATAAAAATTTTGTTGATAACTCTGTTTAAAACATTTAACTTACATAATTCTGTTTACATACACAACAATAATAAATATAT
TTATTATTTTAGTATTTAGT

Downstream 100 bases:

>100_bases
AAGAAGAAAAATAGCAATAGTACTTTTTAATTTAGGAGGTCCAAAAGACCTTAAATCAGTGAAGTATTTTCTGTTTAATC
TGTTCTATGACAAAGCTATA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MNQISNPLKGNNNKIPIWFMRQAGRYLSEYKKVRETTKNFLDFCYDVNKATEVTLQPIKRYGFDAAIIFSDILVLPHAFG
WEIDFKENIGPILKQFKSQEDFKYLQSNPNNKLGKVYEIIKKVKADLTSTTSLIGFAGSPWTVMSYMLEGKGKHDFKTSK
KFIYENKILAKELLNFITEKTADHLINQAKSGADVLKLFDSWSGVLPEDEFTKFVIEPTKKIILKVKEVFPKIPMIAFPK
GAGLLYEKFIKEVPVDILAVDQMVPLEKMKKWSDKVIVQGNLDPVVLLTNKEIIKEKAYKIIQEMKGKNFIFNLGHGILP
KTPPENVEFLTECIRSCE

Sequences:

>Translated_338_residues
MNQISNPLKGNNNKIPIWFMRQAGRYLSEYKKVRETTKNFLDFCYDVNKATEVTLQPIKRYGFDAAIIFSDILVLPHAFG
WEIDFKENIGPILKQFKSQEDFKYLQSNPNNKLGKVYEIIKKVKADLTSTTSLIGFAGSPWTVMSYMLEGKGKHDFKTSK
KFIYENKILAKELLNFITEKTADHLINQAKSGADVLKLFDSWSGVLPEDEFTKFVIEPTKKIILKVKEVFPKIPMIAFPK
GAGLLYEKFIKEVPVDILAVDQMVPLEKMKKWSDKVIVQGNLDPVVLLTNKEIIKEKAYKIIQEMKGKNFIFNLGHGILP
KTPPENVEFLTECIRSCE
>Mature_338_residues
MNQISNPLKGNNNKIPIWFMRQAGRYLSEYKKVRETTKNFLDFCYDVNKATEVTLQPIKRYGFDAAIIFSDILVLPHAFG
WEIDFKENIGPILKQFKSQEDFKYLQSNPNNKLGKVYEIIKKVKADLTSTTSLIGFAGSPWTVMSYMLEGKGKHDFKTSK
KFIYENKILAKELLNFITEKTADHLINQAKSGADVLKLFDSWSGVLPEDEFTKFVIEPTKKIILKVKEVFPKIPMIAFPK
GAGLLYEKFIKEVPVDILAVDQMVPLEKMKKWSDKVIVQGNLDPVVLLTNKEIIKEKAYKIIQEMKGKNFIFNLGHGILP
KTPPENVEFLTECIRSCE

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=334, Percent_Identity=32.9341317365269, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI2367337, Length=326, Percent_Identity=34.9693251533742, Blast_Score=208, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320252, Length=336, Percent_Identity=35.4166666666667, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19921920, Length=332, Percent_Identity=34.9397590361446, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330099, Length=332, Percent_Identity=34.9397590361446, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_RICAH (A8GQC1)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001494104.1
- ProteinModelPortal:   A8GQC1
- SMR:   A8GQC1
- STRING:   A8GQC1
- GeneID:   5645044
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_06880
- NMPDR:   fig|293614.3.peg.1301
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   RAKA293614:A1C_06880-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38785; Mature: 38785

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 71-71 BINDING 146-146 BINDING 201-201 BINDING 316-316

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQISNPLKGNNNKIPIWFMRQAGRYLSEYKKVRETTKNFLDFCYDVNKATEVTLQPIKR
CCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YGFDAAIIFSDILVLPHAFGWEIDFKENIGPILKQFKSQEDFKYLQSNPNNKLGKVYEII
HCCCHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHH
KKVKADLTSTTSLIGFAGSPWTVMSYMLEGKGKHDFKTSKKFIYENKILAKELLNFITEK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TADHLINQAKSGADVLKLFDSWSGVLPEDEFTKFVIEPTKKIILKVKEVFPKIPMIAFPK
HHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
GAGLLYEKFIKEVPVDILAVDQMVPLEKMKKWSDKVIVQGNLDPVVLLTNKEIIKEKAYK
CCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHH
IIQEMKGKNFIFNLGHGILPKTPPENVEFLTECIRSCE
HHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNQISNPLKGNNNKIPIWFMRQAGRYLSEYKKVRETTKNFLDFCYDVNKATEVTLQPIKR
CCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YGFDAAIIFSDILVLPHAFGWEIDFKENIGPILKQFKSQEDFKYLQSNPNNKLGKVYEII
HCCCHHHHHHHHHHHCHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHH
KKVKADLTSTTSLIGFAGSPWTVMSYMLEGKGKHDFKTSKKFIYENKILAKELLNFITEK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TADHLINQAKSGADVLKLFDSWSGVLPEDEFTKFVIEPTKKIILKVKEVFPKIPMIAFPK
HHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
GAGLLYEKFIKEVPVDILAVDQMVPLEKMKKWSDKVIVQGNLDPVVLLTNKEIIKEKAYK
CCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHH
IIQEMKGKNFIFNLGHGILPKTPPENVEFLTECIRSCE
HHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA