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The map label for this gene is hemH [H]

Identifier: 157826383

GI number: 157826383

Start: 1228631

End: 1229665

Strand: Reverse

Name: hemH [H]

Synonym: A1C_06875

Alternate gene names: 157826383

Gene position: 1229665-1228631 (Counterclockwise)

Preceding gene: 157826384

Following gene: 157826382

Centisome position: 99.89

GC content: 27.05

Gene sequence:

>1035_bases
GTGAATAAAAGAAGAAAAATAGCAATAGTACTTTTTAATTTAGGAGGTCCAAAAGACCTTAAATCAGTGAAGTATTTTCT
GTTTAATCTGTTCTATGACAAAGCTATAATTAATCTACCGAATCCATTACGATATATTATTGCAAAAATAATTTCTATCA
CTAGAGAGAAAAAATCTCAAAAAATTTATTCTTTAATCGGTGGTAAATCTTCTTTACTTCAGGAAACAGAGGAGCAGAAA
TTAGCACTAACCGAAAAGTTAAAACAACTTATAAAAGAAGATTTTGCTATTTTTATAAATATGAGATATTCAGCACCGTT
TGCTAAAGAAGTAATAGGTCAAATAAAAATATATAATCCGAGTGAAATAATATTATTGCCTCTATATCCTCAATTTTCAA
GTACTACGACAGGATCATCGGTTAAAAATTTTTTACAAAACCTTGATATTGATATTCCAATTAAAACAATTTGTTGTTAT
CCTACAGAAGAACATTTTATAAAAACCCATGTTTCATTGATTAATGAAAAACTCAACGATAAAAATTTTCGTGTATTATT
TTCTGCTCACGGGTTACCAGAAAAAATAATAAAAGCAGGTGACCCTTATAGTTTTCAGATAAAAGAAACTGTAAAAGCAA
TAGTCAAAGAATTAAATATAAAAGATCTAGATTATAAGATAACTTACCAAAGTAGAGTAGGACATATAGAGTGGTTAAAA
CCAAATACGGAAAATGAAATAGAGCTAGCAGGAAAGTTAAAAAAAAACATAATTATCGTACCTATATCATTTGTATCCGA
GCATGTTGAAACACTAGTAGAACTTGATATTGAATATAAATTAATCGCAGATAAATATGAAATTCAATATACTCGAATTC
CGACACTTGGAACAAATAAAATTTTTATTAATAGTTTGACAAATATATTGCTACGATTTATCAATAAGGTTGATACTAAT
TTAGTCACGAGTAGTTCTAGTACAAGAATATGTCCAAGCGAATTTACTAAATGTTTATGTAAATTAACAAATTAA

Upstream 100 bases:

>100_bases
GAAATGAAAGGAAAGAATTTTATCTTTAATTTAGGACATGGTATTTTGCCTAAAACACCTCCGGAAAATGTAGAATTTTT
AACAGAGTGTATTAGGTCTT

Downstream 100 bases:

>100_bases
TAAGGAAAAGAATGGCAAGTTACTATCTATGGTTTAAGTCAGTACATCTGATATCTGCTATATGTTGGATGGCAGGACTT
CTTTATTTGCCTAGAATATA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MNKRRKIAIVLFNLGGPKDLKSVKYFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQKIYSLIGGKSSLLQETEEQK
LALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKIYNPSEIILLPLYPQFSSTTTGSSVKNFLQNLDIDIPIKTICCY
PTEEHFIKTHVSLINEKLNDKNFRVLFSAHGLPEKIIKAGDPYSFQIKETVKAIVKELNIKDLDYKITYQSRVGHIEWLK
PNTENEIELAGKLKKNIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYTRIPTLGTNKIFINSLTNILLRFINKVDTN
LVTSSSSTRICPSEFTKCLCKLTN

Sequences:

>Translated_344_residues
MNKRRKIAIVLFNLGGPKDLKSVKYFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQKIYSLIGGKSSLLQETEEQK
LALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKIYNPSEIILLPLYPQFSSTTTGSSVKNFLQNLDIDIPIKTICCY
PTEEHFIKTHVSLINEKLNDKNFRVLFSAHGLPEKIIKAGDPYSFQIKETVKAIVKELNIKDLDYKITYQSRVGHIEWLK
PNTENEIELAGKLKKNIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYTRIPTLGTNKIFINSLTNILLRFINKVDTN
LVTSSSSTRICPSEFTKCLCKLTN
>Mature_344_residues
MNKRRKIAIVLFNLGGPKDLKSVKYFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQKIYSLIGGKSSLLQETEEQK
LALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKIYNPSEIILLPLYPQFSSTTTGSSVKNFLQNLDIDIPIKTICCY
PTEEHFIKTHVSLINEKLNDKNFRVLFSAHGLPEKIIKAGDPYSFQIKETVKAIVKELNIKDLDYKITYQSRVGHIEWLK
PNTENEIELAGKLKKNIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYTRIPTLGTNKIFINSLTNILLRFINKVDTN
LVTSSSSTRICPSEFTKCLCKLTN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=346, Percent_Identity=30.9248554913295, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI60499025, Length=346, Percent_Identity=30.9248554913295, Blast_Score=144, Evalue=9e-35,
Organism=Escherichia coli, GI1786681, Length=325, Percent_Identity=24.6153846153846, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324750, Length=322, Percent_Identity=29.8136645962733, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17864156, Length=327, Percent_Identity=33.0275229357798, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=30.2681992337165, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45552018, Length=178, Percent_Identity=35.9550561797753, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39531; Mature: 39531

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRRKIAIVLFNLGGPKDLKSVKYFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQ
CCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KIYSLIGGKSSLLQETEEQKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKIYNP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCEEEEECC
SEIILLPLYPQFSSTTTGSSVKNFLQNLDIDIPIKTICCYPTEEHFIKTHVSLINEKLND
CCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCC
KNFRVLFSAHGLPEKIIKAGDPYSFQIKETVKAIVKELNIKDLDYKITYQSRVGHIEWLK
CCEEEEEECCCCCHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEC
PNTENEIELAGKLKKNIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYTRIPTLGTNK
CCCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCEEEEEECEEEEEEEECCCCCCCH
IFINSLTNILLRFINKVDTNLVTSSSSTRICPSEFTKCLCKLTN
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNKRRKIAIVLFNLGGPKDLKSVKYFLFNLFYDKAIINLPNPLRYIIAKIISITREKKSQ
CCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KIYSLIGGKSSLLQETEEQKLALTEKLKQLIKEDFAIFINMRYSAPFAKEVIGQIKIYNP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCEEEEECC
SEIILLPLYPQFSSTTTGSSVKNFLQNLDIDIPIKTICCYPTEEHFIKTHVSLINEKLND
CCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCC
KNFRVLFSAHGLPEKIIKAGDPYSFQIKETVKAIVKELNIKDLDYKITYQSRVGHIEWLK
CCEEEEEECCCCCHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEC
PNTENEIELAGKLKKNIIIVPISFVSEHVETLVELDIEYKLIADKYEIQYTRIPTLGTNK
CCCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCEEEEEECEEEEEEEECCCCCCCH
IFINSLTNILLRFINKVDTNLVTSSSSTRICPSEFTKCLCKLTN
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]