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The map label for this gene is lipB [H]

Identifier: 157826368

GI number: 157826368

Start: 1217101

End: 1217730

Strand: Reverse

Name: lipB [H]

Synonym: A1C_06785

Alternate gene names: 157826368

Gene position: 1217730-1217101 (Counterclockwise)

Preceding gene: 157826369

Following gene: 157826367

Centisome position: 98.92

GC content: 27.94

Gene sequence:

>630_bases
ATGCTACAATTTATAACTATACCGAATCTTATGGATTATCGGGTTACTTTGAAATTAATGGAAGATTACGTTAATAAAGT
AATTAGTGATAATGAGCTGGAAGTTGTTTATTTAGTTGAACATTCGGAAGTATATACAGCCGGTACTAATTATAAACAAG
AAGAATTATTAAATTACGGTGATATTCCTGTAATTTACACAGGACGTGGCGGTAAATTTACTTTTCATGGACCGGGTCAG
CGTGTTATTTATCCAATTCTTAATTTAGCTTCACCAAATCGACACAAAGATTTAAAGCTATATATAAGAATGCTTGAAGA
ATGGATTATAAATAGCTTAAATTATTTTGGAATTAAAGCATATCTTATTAAAGATAAAGTAGGAATTTGGGTAAAAGTAA
GAAAAGATGAATTTGCTAAAATTGCTGCAATAGGTGTCAGAGTAAGAAAATGGGTTACATATCACGGTGTATCTATAAAT
ATTTCAACAGATTTAAGTAAGTTTAGAGGGATTATTCCTTGTGGACTTGAAAATTCTTTAGTAACATCTTTAAATCAGTT
AGGAATTCATATTGAAATGTCTGAATTTGATAAAATTATTCAAAATGAATTTAATAAAATATTTAAATGA

Upstream 100 bases:

>100_bases
ATTTTTCCGGCGATTTGGATGCTGAAACCATAGCAATTTTAGATGCATTAATATTGAAATATAAATCTGAGTTAAGTAAT
TAATATGACACATTTATAAT

Downstream 100 bases:

>100_bases
TCAGAAAATTTTTACTCACAATTTTAGCAATTTTTGCTCTTTGGGTCGGTGGTATTGGTTATTTTTTATATTTAATAAAT
TCTTATAAGTTCAATAGTAA

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MLQFITIPNLMDYRVTLKLMEDYVNKVISDNELEVVYLVEHSEVYTAGTNYKQEELLNYGDIPVIYTGRGGKFTFHGPGQ
RVIYPILNLASPNRHKDLKLYIRMLEEWIINSLNYFGIKAYLIKDKVGIWVKVRKDEFAKIAAIGVRVRKWVTYHGVSIN
ISTDLSKFRGIIPCGLENSLVTSLNQLGIHIEMSEFDKIIQNEFNKIFK

Sequences:

>Translated_209_residues
MLQFITIPNLMDYRVTLKLMEDYVNKVISDNELEVVYLVEHSEVYTAGTNYKQEELLNYGDIPVIYTGRGGKFTFHGPGQ
RVIYPILNLASPNRHKDLKLYIRMLEEWIINSLNYFGIKAYLIKDKVGIWVKVRKDEFAKIAAIGVRVRKWVTYHGVSIN
ISTDLSKFRGIIPCGLENSLVTSLNQLGIHIEMSEFDKIIQNEFNKIFK
>Mature_209_residues
MLQFITIPNLMDYRVTLKLMEDYVNKVISDNELEVVYLVEHSEVYTAGTNYKQEELLNYGDIPVIYTGRGGKFTFHGPGQ
RVIYPILNLASPNRHKDLKLYIRMLEEWIINSLNYFGIKAYLIKDKVGIWVKVRKDEFAKIAAIGVRVRKWVTYHGVSIN
ISTDLSKFRGIIPCGLENSLVTSLNQLGIHIEMSEFDKIIQNEFNKIFK

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=190, Percent_Identity=34.7368421052632, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI87081767, Length=177, Percent_Identity=35.5932203389831, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323268, Length=126, Percent_Identity=38.8888888888889, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355483, Length=180, Percent_Identity=37.2222222222222, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 24224; Mature: 24224

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQFITIPNLMDYRVTLKLMEDYVNKVISDNELEVVYLVEHSEVYTAGTNYKQEELLNYG
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCHHHHCCCC
DIPVIYTGRGGKFTFHGPGQRVIYPILNLASPNRHKDLKLYIRMLEEWIINSLNYFGIKA
CCCEEEECCCCEEEEECCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
YLIKDKVGIWVKVRKDEFAKIAAIGVRVRKWVTYHGVSINISTDLSKFRGIIPCGLENSL
EEEECCCEEEEEECCCCHHHHHHHHHHHHHEEEEECEEEEEECCHHHHCCCCCCCCCHHH
VTSLNQLGIHIEMSEFDKIIQNEFNKIFK
HHHHHHCCEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLQFITIPNLMDYRVTLKLMEDYVNKVISDNELEVVYLVEHSEVYTAGTNYKQEELLNYG
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCHHHHCCCC
DIPVIYTGRGGKFTFHGPGQRVIYPILNLASPNRHKDLKLYIRMLEEWIINSLNYFGIKA
CCCEEEECCCCEEEEECCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
YLIKDKVGIWVKVRKDEFAKIAAIGVRVRKWVTYHGVSINISTDLSKFRGIIPCGLENSL
EEEECCCEEEEEECCCCHHHHHHHHHHHHHEEEEECEEEEEECCHHHHCCCCCCCCCHHH
VTSLNQLGIHIEMSEFDKIIQNEFNKIFK
HHHHHHCCEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA