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The map label for this gene is nuoL [H]

Identifier: 157826244

GI number: 157826244

Start: 1097358

End: 1099328

Strand: Direct

Name: nuoL [H]

Synonym: A1C_06115

Alternate gene names: 157826244

Gene position: 1097358-1099328 (Clockwise)

Preceding gene: 157826243

Following gene: 157826245

Centisome position: 89.14

GC content: 34.65

Gene sequence:

>1971_bases
ATGTATCAAAATCTTGCCATGATGATCATCATGTTACCGCTTGCATCTAGCGTAATAAACGGATTATTTTTAAAGTTAAT
AGATAAAAATTTAGCTCAAATAATTGCAACAGGTTTTTTGTCATTATCTGCCTTATTCTCATTAATAATATTTTGCGATG
TGGGTTTAGGCGGGAATATAATCCATATTCAGTTATTACCATGGATTGAGGTTGGAAATTTTAAAGTAAATTGGTCGATT
TATATCGATCAGCTCACTAGCATAATGTTTGTAGCAGTAACATGGGTGTCAAGCGTCGTGCATATTTACTCGCTTGGCTA
TATGGCGGAGGATAAGGGAATTGTACGTTTTTTGTCTTTTCTTTCTTTGTTCACCTTTTGTATGTTAATGCTAGTATCAG
CAGATAATTTCTTACAATTATTTTTCGGCTGGGAGGGCGTCGGGGTTTGCTCATATTTACTAATCGGATTTTGGTATTCA
AAAGAATCAGCCAATAAAGCAGCGATTAAAGCTTTTGTTGCAAATAGAGTCGGCGATTTTGCTTTTATCTTGAGCGTAAT
AACGATTATTGTTTATTGTGGTTCAGCAAATTATAAAGATGTATTTGCATCTGCAGAGTTACTATCTAATACAAAAATAT
TTTTACATTTTTCCATTCTAGACATTATTTGCTTTTTATTATTCATCAGTTGTATGGGTAAATCTGCACAGATCGGTTTA
CATGTATGGCTGCCTGATGCGATGGAAGGACCAACTCCCGTATCCGCACTTATTCACGCAGCAACTATGGTAACAGCGGG
AGTATTCTTAGTAGCACGCTGCTCTTATGTGTTTGAATATAGCCCTTTAGTTCTACAATTTATTACAATGATAGGTGGCA
TTACTTGTCTTTTTGCCGCAAGCATTGCTATTATGCAAAGCGATATCAAAAAAATTATTGCTTACTCTACCTGTAGTCAG
CTTGGTTATATGTTTATGGCTTGCGGGGTATCTGCCTATAATAGCGGGATATTTCACTTAGTAACTCACGCATTTTTTAA
AGCCTTATTATTTTTATCAGCGGGCAGTGTAATACACGCAGTTCATGAGCAAGATATTTTTAAAATTGGTGATTTAAGAA
ATAAAATGCCGGTAACTTACGGAAACTTCTTAATCGGTTCACTCGCATTAATAGGAATTTATCCCCTTGCAGGGTTTTAC
TCTAAAGATTCGATTTTAGAATCAGTGTATAGTAGTGGCTCGTTTATGTTTATTTTTGGAATAGCAGCAGCAATACTTAC
CGCTATTTATTCAATGAAGATTATTATGTTGGTATTTCATGGTAAAACTAAACTAGCAAAAGATGTTTTTGAGCATGCCC
ATGAACCGGCTAAAATAATGCATAATCCTCTTATATTACTTGTTGCTGGGAGCTTTTTTAGCGGTATGATCGGCTATTAT
TTACTTTCTATGGACAAACCAAACGGCTATTTCCATGACAGTCTATTTCATTTACATATTTATAAACTACTAATTAGCCA
CCCGCCTTTATATATTAAGCTACTACCTATGGCAGTTGGTATAATTGGGATTGTTATTGGGATTTGGATATTTTCATTGT
CATCCCGCGAGCTTGTAGTGGAATCTAATAAAAATAAAAACAACTGGATCCAGTGGTCAAGCCACGGGATCACACCCATT
GGATTAATTGCCAACATACTAAGAAATAAATATTACTTCGACGAGATATATAATTTCTTAATTGTTAAGCCTACTAACTG
TTTAGCCTATTTATTTTATCTTGGTGACCAAAAAATAATCGATCGTTTTGGACCGAATGGTTTTTCACGCGTTGTTAGTT
GCTTTAGCGTTCTTACCGGAAAAACACAAACGGGATATGTTTTTAATTATGCTTTGTATATAGTATTATTTATTGTTGTA
ACAATTAGTTATTTTGTTTGGAAAGGCTTTGAGTGTCATACCGTTGCTTGA

Upstream 100 bases:

>100_bases
GCAGCTGCCGAAACCTCAATAGGGCTTGCAATATTACTAATATATTTCCGTAATAAAGGCTCAATTGAAATCACTGACAT
TAATCAGATGAGGGGGTGAG

Downstream 100 bases:

>100_bases
CAACGGGGTCCAGTTAAAAATACTAAATTATTAGTATTTTTAGTTGTTTGTTTGATACTGTGGTCAAGCCTCAGTATGAC
ATCGAATGCGTTTTTCGATC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MYQNLAMMIIMLPLASSVINGLFLKLIDKNLAQIIATGFLSLSALFSLIIFCDVGLGGNIIHIQLLPWIEVGNFKVNWSI
YIDQLTSIMFVAVTWVSSVVHIYSLGYMAEDKGIVRFLSFLSLFTFCMLMLVSADNFLQLFFGWEGVGVCSYLLIGFWYS
KESANKAAIKAFVANRVGDFAFILSVITIIVYCGSANYKDVFASAELLSNTKIFLHFSILDIICFLLFISCMGKSAQIGL
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYVFEYSPLVLQFITMIGGITCLFAASIAIMQSDIKKIIAYSTCSQ
LGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHAVHEQDIFKIGDLRNKMPVTYGNFLIGSLALIGIYPLAGFY
SKDSILESVYSSGSFMFIFGIAAAILTAIYSMKIIMLVFHGKTKLAKDVFEHAHEPAKIMHNPLILLVAGSFFSGMIGYY
LLSMDKPNGYFHDSLFHLHIYKLLISHPPLYIKLLPMAVGIIGIVIGIWIFSLSSRELVVESNKNKNNWIQWSSHGITPI
GLIANILRNKYYFDEIYNFLIVKPTNCLAYLFYLGDQKIIDRFGPNGFSRVVSCFSVLTGKTQTGYVFNYALYIVLFIVV
TISYFVWKGFECHTVA

Sequences:

>Translated_656_residues
MYQNLAMMIIMLPLASSVINGLFLKLIDKNLAQIIATGFLSLSALFSLIIFCDVGLGGNIIHIQLLPWIEVGNFKVNWSI
YIDQLTSIMFVAVTWVSSVVHIYSLGYMAEDKGIVRFLSFLSLFTFCMLMLVSADNFLQLFFGWEGVGVCSYLLIGFWYS
KESANKAAIKAFVANRVGDFAFILSVITIIVYCGSANYKDVFASAELLSNTKIFLHFSILDIICFLLFISCMGKSAQIGL
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYVFEYSPLVLQFITMIGGITCLFAASIAIMQSDIKKIIAYSTCSQ
LGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHAVHEQDIFKIGDLRNKMPVTYGNFLIGSLALIGIYPLAGFY
SKDSILESVYSSGSFMFIFGIAAAILTAIYSMKIIMLVFHGKTKLAKDVFEHAHEPAKIMHNPLILLVAGSFFSGMIGYY
LLSMDKPNGYFHDSLFHLHIYKLLISHPPLYIKLLPMAVGIIGIVIGIWIFSLSSRELVVESNKNKNNWIQWSSHGITPI
GLIANILRNKYYFDEIYNFLIVKPTNCLAYLFYLGDQKIIDRFGPNGFSRVVSCFSVLTGKTQTGYVFNYALYIVLFIVV
TISYFVWKGFECHTVA
>Mature_656_residues
MYQNLAMMIIMLPLASSVINGLFLKLIDKNLAQIIATGFLSLSALFSLIIFCDVGLGGNIIHIQLLPWIEVGNFKVNWSI
YIDQLTSIMFVAVTWVSSVVHIYSLGYMAEDKGIVRFLSFLSLFTFCMLMLVSADNFLQLFFGWEGVGVCSYLLIGFWYS
KESANKAAIKAFVANRVGDFAFILSVITIIVYCGSANYKDVFASAELLSNTKIFLHFSILDIICFLLFISCMGKSAQIGL
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYVFEYSPLVLQFITMIGGITCLFAASIAIMQSDIKKIIAYSTCSQ
LGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHAVHEQDIFKIGDLRNKMPVTYGNFLIGSLALIGIYPLAGFY
SKDSILESVYSSGSFMFIFGIAAAILTAIYSMKIIMLVFHGKTKLAKDVFEHAHEPAKIMHNPLILLVAGSFFSGMIGYY
LLSMDKPNGYFHDSLFHLHIYKLLISHPPLYIKLLPMAVGIIGIVIGIWIFSLSSRELVVESNKNKNNWIQWSSHGITPI
GLIANILRNKYYFDEIYNFLIVKPTNCLAYLFYLGDQKIIDRFGPNGFSRVVSCFSVLTGKTQTGYVFNYALYIVLFIVV
TISYFVWKGFECHTVA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=465, Percent_Identity=39.5698924731183, Blast_Score=304, Evalue=2e-82,
Organism=Escherichia coli, GI1788614, Length=641, Percent_Identity=36.1934477379095, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1788829, Length=347, Percent_Identity=30.2593659942363, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1788827, Length=358, Percent_Identity=29.608938547486, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1788831, Length=352, Percent_Identity=29.2613636363636, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788613, Length=392, Percent_Identity=24.7448979591837, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI2367154, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73056; Mature: 73056

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQNLAMMIIMLPLASSVINGLFLKLIDKNLAQIIATGFLSLSALFSLIIFCDVGLGGNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IHIQLLPWIEVGNFKVNWSIYIDQLTSIMFVAVTWVSSVVHIYSLGYMAEDKGIVRFLSF
EEEEEECEEEECCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LSLFTFCMLMLVSADNFLQLFFGWEGVGVCSYLLIGFWYSKESANKAAIKAFVANRVGDF
HHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AFILSVITIIVYCGSANYKDVFASAELLSNTKIFLHFSILDIICFLLFISCMGKSAQIGL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEE
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYVFEYSPLVLQFITMIGGITCLFAA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SIAIMQSDIKKIIAYSTCSQLGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHH
VHEQDIFKIGDLRNKMPVTYGNFLIGSLALIGIYPLAGFYSKDSILESVYSSGSFMFIFG
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHH
IAAAILTAIYSMKIIMLVFHGKTKLAKDVFEHAHEPAKIMHNPLILLVAGSFFSGMIGYY
HHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHHHHHH
LLSMDKPNGYFHDSLFHLHIYKLLISHPPLYIKLLPMAVGIIGIVIGIWIFSLSSRELVV
HEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ESNKNKNNWIQWSSHGITPIGLIANILRNKYYFDEIYNFLIVKPTNCLAYLFYLGDQKII
ECCCCCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHCCHHHH
DRFGPNGFSRVVSCFSVLTGKTQTGYVFNYALYIVLFIVVTISYFVWKGFECHTVA
HHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MYQNLAMMIIMLPLASSVINGLFLKLIDKNLAQIIATGFLSLSALFSLIIFCDVGLGGNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
IHIQLLPWIEVGNFKVNWSIYIDQLTSIMFVAVTWVSSVVHIYSLGYMAEDKGIVRFLSF
EEEEEECEEEECCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LSLFTFCMLMLVSADNFLQLFFGWEGVGVCSYLLIGFWYSKESANKAAIKAFVANRVGDF
HHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
AFILSVITIIVYCGSANYKDVFASAELLSNTKIFLHFSILDIICFLLFISCMGKSAQIGL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEE
HVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYVFEYSPLVLQFITMIGGITCLFAA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SIAIMQSDIKKIIAYSTCSQLGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHH
VHEQDIFKIGDLRNKMPVTYGNFLIGSLALIGIYPLAGFYSKDSILESVYSSGSFMFIFG
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHHHH
IAAAILTAIYSMKIIMLVFHGKTKLAKDVFEHAHEPAKIMHNPLILLVAGSFFSGMIGYY
HHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHHHHHH
LLSMDKPNGYFHDSLFHLHIYKLLISHPPLYIKLLPMAVGIIGIVIGIWIFSLSSRELVV
HEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ESNKNKNNWIQWSSHGITPIGLIANILRNKYYFDEIYNFLIVKPTNCLAYLFYLGDQKII
ECCCCCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHCCEEEECCCHHHHHHHHHCCHHHH
DRFGPNGFSRVVSCFSVLTGKTQTGYVFNYALYIVLFIVVTISYFVWKGFECHTVA
HHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]