Click here to switch to the map view.

The map label for this gene is nuoM [H]

Identifier: 157826245

GI number: 157826245

Start: 1099479

End: 1100960

Strand: Direct

Name: nuoM [H]

Synonym: A1C_06120

Alternate gene names: 157826245

Gene position: 1099479-1100960 (Clockwise)

Preceding gene: 157826244

Following gene: 157826246

Centisome position: 89.31

GC content: 33.27

Gene sequence:

>1482_bases
ATGTTAGAATTACCTATTATATCTATCAGTATTTTTCTGCCGCTAATAAGCGTGCTATATATTTTGCTGTTTATGAGTCA
AAGTAAAAAGACGGATAAATCGATATATGTAATGTATGTGGCGGTGCTTAGTTCTGTTTTAACATTCATCTCAACTATCT
ATATTTTAATAGAGTTTAACTCCTCAAATCCTGCTTATCAATTTGTTGAACGCTACGCTTGGCTTGATAAAATCGGGCTT
GAATTTCATGTTGGTGTTGACGGTATATCAATATTTTTTGTTGCTCTAACTTCTTTTCTTACTCTTGTTTGTATAATCGG
AAGCTTATTTACCATTAAAAAATATATTAAAGAATATTTAGTATGTTTTTTATTAATGGAATCTTTTTGTATAGGAGCAT
TTACCTCAGTAAATTTATTATTATTCTATCTCTTTTTTGAAGCAATATTAGTGCCGATGTATATCATTATAGGCGTATGG
GGTGGCGAGAACAGAATATATGCGGCTCTTAAATTCTTCTTATATACTTTCTTCGGCTCGGTATTTTTCTTACTTTCATT
AATTTATATTTACAGTAAAATTCATAGTTTTGATTTAACTTATATTCCTGAACTTACTGATAATATTCCGTTATTTGCTC
AGCAAATTTTATGGTGGGCTATCTTTATAGCCTTTGCCATTAAAATCCCTATGATTCCGGTGCATACTTGGCTACCTGAC
GCACACGTACAAGCTCCAACTAGCGGCTCGGTTATTCTTGCTGGTATTCTGATAAAACTTGGCGGTTACGGTTTTTTAAG
AGTATTACTACCGCTACTCCCAAGTGTATCACAAGAATTTGCAATTTACGTAATTTACCTTAGCATTATTGCTATAATAT
ATGCTTCCCTTGTTGCTCTTGCTCAAAAAGATATGAAGAAGATGATAGCCTATTCATCAATTGCACATATGGGATATGTT
ACGATAGGTATTTTTAGCTTTACTGACGCCGGGGTTAATGGAGCAATATTTCAGATGCTTAGCCATGGAGTGATTTCCTC
ATGCCTATTCTTAATAGTCGGTACTTTGTACGAAAGATTACACACTAAAGAAATAGCTAAATACGGCGGTGTAGCAAGTA
AAATGCATGTGCTTGCCACATTTTTTATGATTGCAATGCTTGGCTCTGTCGGCCTGCCAGGTACTAGCGGATTTATTGGA
GAATTTTTAAGCTTGCTTGGGACGTATAAGGTGAATGTAGCAGCAACTTGTGTAGCGGCTCTCGGCATAATCATTGGGGC
GGTTTATATGCTGAAATTATATAAAGAAATTATGCTTGGTGAAATTACCAATAAAGAAATTATGCATTTCAGAGATTTAT
ATAAATATGAAATAATCTCAATAGCTCCTTTAATATTATTAATTATTTACTTTGGTCTAATGCCGAGTTCTATTCTAAAT
GTATTTAGTTTTTCGGTGAAGAATTTATTGGTTAAATTTTAA

Upstream 100 bases:

>100_bases
TTTGATACTGTGGTCAAGCCTCAGTATGACATCGAATGCGTTTTTCGATCCAAGTAAGAATGATATATACTACTAAAAAA
ACTTATAAAATCTTAAAAGA

Downstream 100 bases:

>100_bases
TTGCTTACAAAAAATATAAATGCTACTCTAATTATAGAACTTAAAAGTGAGTTCTATATAGCAAAAGATGCTAATAAAGT
AACAGGCATAGATATAGTCA

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MLELPIISISIFLPLISVLYILLFMSQSKKTDKSIYVMYVAVLSSVLTFISTIYILIEFNSSNPAYQFVERYAWLDKIGL
EFHVGVDGISIFFVALTSFLTLVCIIGSLFTIKKYIKEYLVCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVW
GGENRIYAALKFFLYTFFGSVFFLLSLIYIYSKIHSFDLTYIPELTDNIPLFAQQILWWAIFIAFAIKIPMIPVHTWLPD
AHVQAPTSGSVILAGILIKLGGYGFLRVLLPLLPSVSQEFAIYVIYLSIIAIIYASLVALAQKDMKKMIAYSSIAHMGYV
TIGIFSFTDAGVNGAIFQMLSHGVISSCLFLIVGTLYERLHTKEIAKYGGVASKMHVLATFFMIAMLGSVGLPGTSGFIG
EFLSLLGTYKVNVAATCVAALGIIIGAVYMLKLYKEIMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
VFSFSVKNLLVKF

Sequences:

>Translated_493_residues
MLELPIISISIFLPLISVLYILLFMSQSKKTDKSIYVMYVAVLSSVLTFISTIYILIEFNSSNPAYQFVERYAWLDKIGL
EFHVGVDGISIFFVALTSFLTLVCIIGSLFTIKKYIKEYLVCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVW
GGENRIYAALKFFLYTFFGSVFFLLSLIYIYSKIHSFDLTYIPELTDNIPLFAQQILWWAIFIAFAIKIPMIPVHTWLPD
AHVQAPTSGSVILAGILIKLGGYGFLRVLLPLLPSVSQEFAIYVIYLSIIAIIYASLVALAQKDMKKMIAYSSIAHMGYV
TIGIFSFTDAGVNGAIFQMLSHGVISSCLFLIVGTLYERLHTKEIAKYGGVASKMHVLATFFMIAMLGSVGLPGTSGFIG
EFLSLLGTYKVNVAATCVAALGIIIGAVYMLKLYKEIMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
VFSFSVKNLLVKF
>Mature_493_residues
MLELPIISISIFLPLISVLYILLFMSQSKKTDKSIYVMYVAVLSSVLTFISTIYILIEFNSSNPAYQFVERYAWLDKIGL
EFHVGVDGISIFFVALTSFLTLVCIIGSLFTIKKYIKEYLVCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVW
GGENRIYAALKFFLYTFFGSVFFLLSLIYIYSKIHSFDLTYIPELTDNIPLFAQQILWWAIFIAFAIKIPMIPVHTWLPD
AHVQAPTSGSVILAGILIKLGGYGFLRVLLPLLPSVSQEFAIYVIYLSIIAIIYASLVALAQKDMKKMIAYSSIAHMGYV
TIGIFSFTDAGVNGAIFQMLSHGVISSCLFLIVGTLYERLHTKEIAKYGGVASKMHVLATFFMIAMLGSVGLPGTSGFIG
EFLSLLGTYKVNVAATCVAALGIIIGAVYMLKLYKEIMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
VFSFSVKNLLVKF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=360, Percent_Identity=32.7777777777778, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI251831117, Length=380, Percent_Identity=24.4736842105263, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788613, Length=441, Percent_Identity=35.827664399093, Blast_Score=284, Evalue=7e-78,
Organism=Escherichia coli, GI1788827, Length=340, Percent_Identity=26.7647058823529, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788831, Length=287, Percent_Identity=23.6933797909408, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788614, Length=419, Percent_Identity=24.582338902148, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788829, Length=272, Percent_Identity=27.2058823529412, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693160, Length=468, Percent_Identity=25.2136752136752, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI2367154, Length=317, Percent_Identity=23.0283911671924, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55188; Mature: 55188

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELPIISISIFLPLISVLYILLFMSQSKKTDKSIYVMYVAVLSSVLTFISTIYILIEFN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEC
SSNPAYQFVERYAWLDKIGLEFHVGVDGISIFFVALTSFLTLVCIIGSLFTIKKYIKEYL
CCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVWGGENRIYAALKFFLYTFFGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
VFFLLSLIYIYSKIHSFDLTYIPELTDNIPLFAQQILWWAIFIAFAIKIPMIPVHTWLPD
HHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCC
AHVQAPTSGSVILAGILIKLGGYGFLRVLLPLLPSVSQEFAIYVIYLSIIAIIYASLVAL
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQKDMKKMIAYSSIAHMGYVTIGIFSFTDAGVNGAIFQMLSHGVISSCLFLIVGTLYERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTKEIAKYGGVASKMHVLATFFMIAMLGSVGLPGTSGFIGEFLSLLGTYKVNVAATCVAA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGIIIGAVYMLKLYKEIMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VFSFSVKNLLVKF
HHHHHHHHHHHCC
>Mature Secondary Structure
MLELPIISISIFLPLISVLYILLFMSQSKKTDKSIYVMYVAVLSSVLTFISTIYILIEFN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEC
SSNPAYQFVERYAWLDKIGLEFHVGVDGISIFFVALTSFLTLVCIIGSLFTIKKYIKEYL
CCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVWGGENRIYAALKFFLYTFFGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHH
VFFLLSLIYIYSKIHSFDLTYIPELTDNIPLFAQQILWWAIFIAFAIKIPMIPVHTWLPD
HHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCC
AHVQAPTSGSVILAGILIKLGGYGFLRVLLPLLPSVSQEFAIYVIYLSIIAIIYASLVAL
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQKDMKKMIAYSSIAHMGYVTIGIFSFTDAGVNGAIFQMLSHGVISSCLFLIVGTLYERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTKEIAKYGGVASKMHVLATFFMIAMLGSVGLPGTSGFIGEFLSLLGTYKVNVAATCVAA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGIIIGAVYMLKLYKEIMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VFSFSVKNLLVKF
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA