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The map label for this gene is relA [H]

Identifier: 157826131

GI number: 157826131

Start: 986442

End: 987047

Strand: Reverse

Name: relA [H]

Synonym: A1C_05540

Alternate gene names: 157826131

Gene position: 987047-986442 (Counterclockwise)

Preceding gene: 157826132

Following gene: 157826130

Centisome position: 80.18

GC content: 31.19

Gene sequence:

>606_bases
TTGATTTGTGATATTATTAATCTGCTTAAAGAAGATTTAAATAAGGCAGATATAGAAAATGAGATATATATGCGTCTTAA
AGGACCTTATTCTGTTTTAACAAAGATGAAAAGGAAAGAAGTGCCGATTGATGCATTGAAAGACTTAATTGCGTGTAGGA
TTATAGTTAAATCTAAAGCTCTATGCTATAATGCTTTGGACGTAGTTAAGAGTTCTTCGCATTTAGATTGGTTATACACC
AAAGATTATATCAATAGACCAAAAAGCAATGGCTATCAGTCTCTGCATAATATAATGCAGTGTTTACACTCTCAACGTAA
TTTTGAAATACAGATACGAAGTGAAGATATGCATAAAGATGCTGAGCTGGGTAGAGCAGCTCATTTAAATTATAAAGAAG
AACAAGACCGTCATTTGAAAAAAGTTTTTGATGTTAGTAATGACACGATACTTTCTAAAGCACGTAAAATGGTGAAACAA
TTTAAAGGATTAGAAGAGCAAATTGTAGAATATGAAAAAGAAATTATGCATATTTGGGATACTAAATATGAAGAAATGCT
AAAATGGGAAAATGCTGCTGCAGTGCTAGTATTTAATGAAGAGTAG

Upstream 100 bases:

>100_bases
TATTTGAGAAAGCAGTATTGGGGGATTTAAGTTCTAAAAGCTATAAGTAATATTTACTAAGAATAGTAGAGATTATAGAA
TTTTAGGTAGCAGGGGGGAT

Downstream 100 bases:

>100_bases
GGCGCATTAGTTCGTAATCCCGTGGTCAAGCCATGGAATGAGAGAGGTGAAATTGATCCATGCAGGTAATACATCCTCGC
AATGACGACCTGTGTGTCAT

Product: guanosine polyphosphate pyrophosphohydrolase/synthetase-like protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MICDIINLLKEDLNKADIENEIYMRLKGPYSVLTKMKRKEVPIDALKDLIACRIIVKSKALCYNALDVVKSSSHLDWLYT
KDYINRPKSNGYQSLHNIMQCLHSQRNFEIQIRSEDMHKDAELGRAAHLNYKEEQDRHLKKVFDVSNDTILSKARKMVKQ
FKGLEEQIVEYEKEIMHIWDTKYEEMLKWENAAAVLVFNEE

Sequences:

>Translated_201_residues
MICDIINLLKEDLNKADIENEIYMRLKGPYSVLTKMKRKEVPIDALKDLIACRIIVKSKALCYNALDVVKSSSHLDWLYT
KDYINRPKSNGYQSLHNIMQCLHSQRNFEIQIRSEDMHKDAELGRAAHLNYKEEQDRHLKKVFDVSNDTILSKARKMVKQ
FKGLEEQIVEYEKEIMHIWDTKYEEMLKWENAAAVLVFNEE
>Mature_201_residues
MICDIINLLKEDLNKADIENEIYMRLKGPYSVLTKMKRKEVPIDALKDLIACRIIVKSKALCYNALDVVKSSSHLDWLYT
KDYINRPKSNGYQSLHNIMQCLHSQRNFEIQIRSEDMHKDAELGRAAHLNYKEEQDRHLKKVFDVSNDTILSKARKMVKQ
FKGLEEQIVEYEKEIMHIWDTKYEEMLKWENAAAVLVFNEE

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=133, Percent_Identity=39.0977443609023, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1790082, Length=133, Percent_Identity=40.6015037593985, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 23753; Mature: 23753

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICDIINLLKEDLNKADIENEIYMRLKGPYSVLTKMKRKEVPIDALKDLIACRIIVKSKA
CHHHHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LCYNALDVVKSSSHLDWLYTKDYINRPKSNGYQSLHNIMQCLHSQRNFEIQIRSEDMHKD
HHHHHHHHHHCCCCCCCEEEHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHCHH
AELGRAAHLNYKEEQDRHLKKVFDVSNDTILSKARKMVKQFKGLEEQIVEYEKEIMHIWD
HHHCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
TKYEEMLKWENAAAVLVFNEE
CHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure
MICDIINLLKEDLNKADIENEIYMRLKGPYSVLTKMKRKEVPIDALKDLIACRIIVKSKA
CHHHHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LCYNALDVVKSSSHLDWLYTKDYINRPKSNGYQSLHNIMQCLHSQRNFEIQIRSEDMHKD
HHHHHHHHHHCCCCCCCEEEHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHCHH
AELGRAAHLNYKEEQDRHLKKVFDVSNDTILSKARKMVKQFKGLEEQIVEYEKEIMHIWD
HHHCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
TKYEEMLKWENAAAVLVFNEE
CHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]