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The map label for this gene is ubiB [H]

Identifier: 157826092

GI number: 157826092

Start: 938746

End: 940182

Strand: Reverse

Name: ubiB [H]

Synonym: A1C_05260

Alternate gene names: 157826092

Gene position: 940182-938746 (Counterclockwise)

Preceding gene: 157826093

Following gene: 157826090

Centisome position: 76.37

GC content: 35.35

Gene sequence:

>1437_bases
ATGATAAATAATTTTTTTAATTTAATACGTATTTTTCGTATCATCAGTAAAAAACGAATTCTAATTGATTCAAGAAGCCC
TAAGTATTTTACGTTTATCGGTTATATATTAGCTTTATTTTCTGCTCCGTTATCATTATTTAAAAAACCGTATGAAGATT
ATGGCAAACGCCTAATAGATTGTTTAAGCGATCTTGGACCTATTTATATAAAATTCGGACAAACTCTTTCGACAAGACCT
GATTTAGTAGGAGCAGAGATAGCAGGTAATTTAAGGGTATTGCAGGATAAGCTAGCTCCGTTTGATGGTGTGGTGGCTAG
AGAAATTATAGAGAGGGAGTTTGGTAAGTGTATTGTCAGCCCGTGGCTTGACCACGGTATCCAGAAAAAAATTAAAAAAG
ACTGGATCCCACAATCAAGTCTCGGGATGACATTGTTTTTAAACAACTCCCCCATTGCCGCCGCATCAATCTCCCAGGTA
CATAAGGCCCAACTCGCAACTGGTGAATATGTTGCGGTAAAAATTCTGCGTCCGGGTATTCATAAAAAATATAACAGAGA
TATTAAGCTGCTATATTTTCTTGCAAAAATTATCGCAAAATTTTCTAAAGCAAAAAGGCTAAAACCAATTAAAGTAGTTG
ATAAATTTCATGAAACTATGAGATTTGAGCTTGATTTAAGGTTAGAAGCGGCAGCTGCTTCTGAGCTTATGGATAATATG
CGACATGATGTTAATGTGATAATCCCTAAAATATATTGGGACTTAACATCAGAAAATATACTAACTACTGAGTGGTTAGA
AGGAACTTCTATATATGATACTTTGCGGCTAGAAGAATTGGGATTAGAGCCTACAAAAATAGCTCAGAATTTTGCCGTAA
TGTTTTTCAATCAAGCCTATAGAGATGGGTTTTTTCATGCTGATTTACATGCAGGCAATATTTTAGTGAATAAGCAAGGT
AAGATAATTTTACTTGATTTTGGTATTATGGGCAGACTTAAAGAAAAAGATCGTTTAGCTGTTGCCGAAAGTCTATTCGG
TTTTTTAAAACGTGATTATAAATTAGTGGCTAAAGTACATTTAAGAGCCGGCTACATCCCATCAAATACCGATTTAGATT
TATTCGCTCAAAGTTGTAGAGCAGTTACTGAGCCTATAGTAGGGATACCCACGAAAAATATTTCCATAGGTAAGCTGCTT
GCACATTTATTTAAAATCACTGAAGAGTTCGGCATGGAAGTACAACCGGAATTATTGTTATTGCAAAAGACTTTGATAAT
GGTTGAAGGGATAGGTAGACAGCTAGACGGTAATGTTAATATGTGGCAACTCGCCGAACCTTGGATTAAAAAATGGGCAG
TAAAAAACTTAAGCACTGAAGCGAAGTTGCTACGATTGGTAAAGCATTACCTAGATATCCTAGAGGATATTGTTTGA

Upstream 100 bases:

>100_bases
AAGACGAGTTTAGAATAATGATTAAAGAAGCCGGTTTTGAGGAAGTTGGTTATAAAAATTTAAGTGGCGGAATAGTTGCT
ATTCACAGTGGATATAAGAT

Downstream 100 bases:

>100_bases
CATATAAAAATTATTAATATTATAGCCTTATATATTAAGAAATTTTTTATTATGAAACTACCAAAAAGATTATTGATAAT
TTAGCTCCTATTTTAGAAAA

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MINNFFNLIRIFRIISKKRILIDSRSPKYFTFIGYILALFSAPLSLFKKPYEDYGKRLIDCLSDLGPIYIKFGQTLSTRP
DLVGAEIAGNLRVLQDKLAPFDGVVAREIIEREFGKCIVSPWLDHGIQKKIKKDWIPQSSLGMTLFLNNSPIAAASISQV
HKAQLATGEYVAVKILRPGIHKKYNRDIKLLYFLAKIIAKFSKAKRLKPIKVVDKFHETMRFELDLRLEAAAASELMDNM
RHDVNVIIPKIYWDLTSENILTTEWLEGTSIYDTLRLEELGLEPTKIAQNFAVMFFNQAYRDGFFHADLHAGNILVNKQG
KIILLDFGIMGRLKEKDRLAVAESLFGFLKRDYKLVAKVHLRAGYIPSNTDLDLFAQSCRAVTEPIVGIPTKNISIGKLL
AHLFKITEEFGMEVQPELLLLQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSTEAKLLRLVKHYLDILEDIV

Sequences:

>Translated_478_residues
MINNFFNLIRIFRIISKKRILIDSRSPKYFTFIGYILALFSAPLSLFKKPYEDYGKRLIDCLSDLGPIYIKFGQTLSTRP
DLVGAEIAGNLRVLQDKLAPFDGVVAREIIEREFGKCIVSPWLDHGIQKKIKKDWIPQSSLGMTLFLNNSPIAAASISQV
HKAQLATGEYVAVKILRPGIHKKYNRDIKLLYFLAKIIAKFSKAKRLKPIKVVDKFHETMRFELDLRLEAAAASELMDNM
RHDVNVIIPKIYWDLTSENILTTEWLEGTSIYDTLRLEELGLEPTKIAQNFAVMFFNQAYRDGFFHADLHAGNILVNKQG
KIILLDFGIMGRLKEKDRLAVAESLFGFLKRDYKLVAKVHLRAGYIPSNTDLDLFAQSCRAVTEPIVGIPTKNISIGKLL
AHLFKITEEFGMEVQPELLLLQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSTEAKLLRLVKHYLDILEDIV
>Mature_478_residues
MINNFFNLIRIFRIISKKRILIDSRSPKYFTFIGYILALFSAPLSLFKKPYEDYGKRLIDCLSDLGPIYIKFGQTLSTRP
DLVGAEIAGNLRVLQDKLAPFDGVVAREIIEREFGKCIVSPWLDHGIQKKIKKDWIPQSSLGMTLFLNNSPIAAASISQV
HKAQLATGEYVAVKILRPGIHKKYNRDIKLLYFLAKIIAKFSKAKRLKPIKVVDKFHETMRFELDLRLEAAAASELMDNM
RHDVNVIIPKIYWDLTSENILTTEWLEGTSIYDTLRLEELGLEPTKIAQNFAVMFFNQAYRDGFFHADLHAGNILVNKQG
KIILLDFGIMGRLKEKDRLAVAESLFGFLKRDYKLVAKVHLRAGYIPSNTDLDLFAQSCRAVTEPIVGIPTKNISIGKLL
AHLFKITEEFGMEVQPELLLLQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSTEAKLLRLVKHYLDILEDIV

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=443, Percent_Identity=25.9593679458239, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI41393593, Length=293, Percent_Identity=28.6689419795222, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI217035081, Length=299, Percent_Identity=28.4280936454849, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI34147522, Length=195, Percent_Identity=29.7435897435897, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI2367309, Length=404, Percent_Identity=39.1089108910891, Blast_Score=289, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17559152, Length=322, Percent_Identity=26.0869565217391, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=187, Percent_Identity=28.8770053475936, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=448, Percent_Identity=21.875, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=243, Percent_Identity=27.9835390946502, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24662575, Length=294, Percent_Identity=29.2517006802721, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI22024280, Length=208, Percent_Identity=29.8076923076923, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 54606; Mature: 54606

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNFFNLIRIFRIISKKRILIDSRSPKYFTFIGYILALFSAPLSLFKKPYEDYGKRLID
CCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
CLSDLGPIYIKFGQTLSTRPDLVGAEIAGNLRVLQDKLAPFDGVVAREIIEREFGKCIVS
HHHCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
PWLDHGIQKKIKKDWIPQSSLGMTLFLNNSPIAAASISQVHKAQLATGEYVAVKILRPGI
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCH
HKKYNRDIKLLYFLAKIIAKFSKAKRLKPIKVVDKFHETMRFELDLRLEAAAASELMDNM
HHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHH
RHDVNVIIPKIYWDLTSENILTTEWLEGTSIYDTLRLEELGLEPTKIAQNFAVMFFNQAY
HCCCEEEEEHHEEECCCCCEEEEHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RDGFFHADLHAGNILVNKQGKIILLDFGIMGRLKEKDRLAVAESLFGFLKRDYKLVAKVH
HCCCEEEEECCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAGYIPSNTDLDLFAQSCRAVTEPIVGIPTKNISIGKLLAHLFKITEEFGMEVQPELLL
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
LQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSTEAKLLRLVKHYLDILEDIV
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINNFFNLIRIFRIISKKRILIDSRSPKYFTFIGYILALFSAPLSLFKKPYEDYGKRLID
CCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
CLSDLGPIYIKFGQTLSTRPDLVGAEIAGNLRVLQDKLAPFDGVVAREIIEREFGKCIVS
HHHCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
PWLDHGIQKKIKKDWIPQSSLGMTLFLNNSPIAAASISQVHKAQLATGEYVAVKILRPGI
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCH
HKKYNRDIKLLYFLAKIIAKFSKAKRLKPIKVVDKFHETMRFELDLRLEAAAASELMDNM
HHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHH
RHDVNVIIPKIYWDLTSENILTTEWLEGTSIYDTLRLEELGLEPTKIAQNFAVMFFNQAY
HCCCEEEEEHHEEECCCCCEEEEHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RDGFFHADLHAGNILVNKQGKIILLDFGIMGRLKEKDRLAVAESLFGFLKRDYKLVAKVH
HCCCEEEEECCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAGYIPSNTDLDLFAQSCRAVTEPIVGIPTKNISIGKLLAHLFKITEEFGMEVQPELLL
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
LQKTLIMVEGIGRQLDGNVNMWQLAEPWIKKWAVKNLSTEAKLLRLVKHYLDILEDIV
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]