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The map label for this gene is ubiE [H]

Identifier: 157826093

GI number: 157826093

Start: 940179

End: 940925

Strand: Reverse

Name: ubiE [H]

Synonym: A1C_05265

Alternate gene names: 157826093

Gene position: 940925-940179 (Counterclockwise)

Preceding gene: 157826094

Following gene: 157826092

Centisome position: 76.43

GC content: 31.33

Gene sequence:

>747_bases
ATGAATCACATAGATTTTGGCTTTAAAAAAGTAGACTACACTAAAAAACAAGGATTAGTAAATAGCGTTTTTTCTAATGT
CGCTGATAAGTATGATTTAATGAATGACTTAATGAGCTTTGGGTTACATCGCTTATGGAAAGATGAATTTATTAGGCGAA
TCCCAAATCTTAACTCTCATATATTAGACGTCGCTAGCGGTAGCGGTGATATTGCTTTAAAACTTGCTAAAAAAGCAAGA
GATAGAGGCAATAATATTGCTTTAACTTTAAGTGACATCAATGAAGAGATGCTAAAGAATGCTAAAAAGAAAACAATTGA
TCTAAACCTATTTCAGAACCTTAAATTTACTGTAGCAAGTGCCGAAGAATTACCTTACCCGGATAATAGTTTCGATTATT
ATACTATAGCATTCGGTATTAGAAACGTACCTGATATTAATAAAGCTTTAAAAGAAGCTTATAGAGTTCTAAAACCGATG
GGTAAGTTTATATGCCTTGAGTTTTCAAAGGTAAAAGAAAGTTATTTTAAAGATTTTTATAAATTTTATTCATTTAGTAT
TATACCTACCATCGGTCAGGTCATCACTGGTAATAAAGAAGCATATGAATATTTGGTTGAAAGTATCGAGTTATTCCCCT
CACAAGACGAGTTTAGAATAATGATTAAAGAAGCCGGTTTTGAGGAAGTTGGTTATAAAAATTTAAGTGGCGGAATAGTT
GCTATTCACAGTGGATATAAGATATGA

Upstream 100 bases:

>100_bases
TATGGGCGACCGCTAAGTACAGCAACAGCTTATTAGTTACTAGAAATACAAAAGATTTTCCCATTCATGCCTCGGGTATA
AAAATTTCATATATATATAA

Downstream 100 bases:

>100_bases
TAAATAATTTTTTTAATTTAATACGTATTTTTCGTATCATCAGTAAAAAACGAATTCTAATTGATTCAAGAAGCCCTAAG
TATTTTACGTTTATCGGTTA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNHIDFGFKKVDYTKKQGLVNSVFSNVADKYDLMNDLMSFGLHRLWKDEFIRRIPNLNSHILDVASGSGDIALKLAKKAR
DRGNNIALTLSDINEEMLKNAKKKTIDLNLFQNLKFTVASAEELPYPDNSFDYYTIAFGIRNVPDINKALKEAYRVLKPM
GKFICLEFSKVKESYFKDFYKFYSFSIIPTIGQVITGNKEAYEYLVESIELFPSQDEFRIMIKEAGFEEVGYKNLSGGIV
AIHSGYKI

Sequences:

>Translated_248_residues
MNHIDFGFKKVDYTKKQGLVNSVFSNVADKYDLMNDLMSFGLHRLWKDEFIRRIPNLNSHILDVASGSGDIALKLAKKAR
DRGNNIALTLSDINEEMLKNAKKKTIDLNLFQNLKFTVASAEELPYPDNSFDYYTIAFGIRNVPDINKALKEAYRVLKPM
GKFICLEFSKVKESYFKDFYKFYSFSIIPTIGQVITGNKEAYEYLVESIELFPSQDEFRIMIKEAGFEEVGYKNLSGGIV
AIHSGYKI
>Mature_248_residues
MNHIDFGFKKVDYTKKQGLVNSVFSNVADKYDLMNDLMSFGLHRLWKDEFIRRIPNLNSHILDVASGSGDIALKLAKKAR
DRGNNIALTLSDINEEMLKNAKKKTIDLNLFQNLKFTVASAEELPYPDNSFDYYTIAFGIRNVPDINKALKEAYRVLKPM
GKFICLEFSKVKESYFKDFYKFYSFSIIPTIGQVITGNKEAYEYLVESIELFPSQDEFRIMIKEAGFEEVGYKNLSGGIV
AIHSGYKI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=274, Percent_Identity=44.8905109489051, Blast_Score=243, Evalue=8e-65,
Organism=Escherichia coli, GI48994983, Length=247, Percent_Identity=44.9392712550607, Blast_Score=225, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17557039, Length=246, Percent_Identity=44.3089430894309, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323526, Length=256, Percent_Identity=45.703125, Blast_Score=208, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24641702, Length=254, Percent_Identity=44.8818897637795, Blast_Score=240, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28413; Mature: 28413

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHIDFGFKKVDYTKKQGLVNSVFSNVADKYDLMNDLMSFGLHRLWKDEFIRRIPNLNSH
CCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ILDVASGSGDIALKLAKKARDRGNNIALTLSDINEEMLKNAKKKTIDLNLFQNLKFTVAS
EEEEECCCCCEEHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHEEEHHHHHCCEEEEEC
AEELPYPDNSFDYYTIAFGIRNVPDINKALKEAYRVLKPMGKFICLEFSKVKESYFKDFY
HHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFYSFSIIPTIGQVITGNKEAYEYLVESIELFPSQDEFRIMIKEAGFEEVGYKNLSGGIV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCHHHCCCCCCCCCEE
AIHSGYKI
EECCCCCC
>Mature Secondary Structure
MNHIDFGFKKVDYTKKQGLVNSVFSNVADKYDLMNDLMSFGLHRLWKDEFIRRIPNLNSH
CCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ILDVASGSGDIALKLAKKARDRGNNIALTLSDINEEMLKNAKKKTIDLNLFQNLKFTVAS
EEEEECCCCCEEHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHEEEHHHHHCCEEEEEC
AEELPYPDNSFDYYTIAFGIRNVPDINKALKEAYRVLKPMGKFICLEFSKVKESYFKDFY
HHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFYSFSIIPTIGQVITGNKEAYEYLVESIELFPSQDEFRIMIKEAGFEEVGYKNLSGGIV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCHHHCCCCCCCCCEE
AIHSGYKI
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA