Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 157825880

GI number: 157825880

Start: 739550

End: 740785

Strand: Reverse

Name: tyrS [H]

Synonym: A1C_04095

Alternate gene names: 157825880

Gene position: 740785-739550 (Counterclockwise)

Preceding gene: 157825881

Following gene: 157825879

Centisome position: 60.17

GC content: 36.73

Gene sequence:

>1236_bases
ATGAGTTTTATAGAAGAATTTATAAATAAAGGATATTTCCATCAATGTACCGATTTGGATCGGTTAACTACTATAACGAA
AGAAACAAAAATAGCGGCTTATATAGGCTTTGACTGTACTGCTACATCGCTACATATCGGTAGTTTAATGCAGATAATGA
TATTACGGTTACTTCAGCGGCATGGGCATAAGCCTATTGTCATTATCGGCGGCGGTACGAGTAAAATCGGTGATCCTACT
TGGAAAGACGAAGCTCGCAAAATTTTAAGCAAAGAAGATATAGCAAAAAATGCTAAAGGGATTAAAAAATCACTATCAAA
ATTTATCAAATTCGGTGATGGTAAAAGTGATGCTATTATGTTCGATAATGTAGAGTGGCTTGATTCTCTTAATTATCTAG
AGTTTTTAAGAGATTTTGGCGTTCATTTTTCGATCAACCGTATGCTTACTATGGATTCGGTAAAACTAAGGCTTGAGCGT
GAGCAGCATTTAAGTTTCTTAGAATTTAACTATATGTTGCTGCAAGCCTATGATTTTTACTATTTAAGCAAGCATTACAA
TTGTAGTTTGCAGCTTGGCGGTAGTGACCAATGGGGCAATATCGTAATGGGAGCGGATTTAATTCGTAAAATAAGTAGAA
AAGAAGTATTCGGTATGACTACGCCACTACTTACGACTAGCTCAGGTGCTAAGATGGGTAAGACTGCTGCAGGGGCAGTA
TGGCTTAATGAAGATTTGTTAAGTCCGTATGATTATTACCAATATTGGCGTAACTGTGAAGATGCCGACGTAATTAGATT
TGCTAAATTGTATAGTGAGTTAACTTCTGAAGAGCTTAATGAATTTGAGAGATTAGCGGCTGAAGATATTAATGCAGCTA
AAAAGAAACTAGCGTATGAGCTAACTAAGCTTTGTCACTCGGAGCAGGCAGCAAAATCAGCGCTGGAAACTGCAGTAAAG
ATATTTGAACAAGGAGAAATCGATGAGAGTTTACCTACCGTTGTTTTAGAGCAGGCACTACTCCAAACCGGTATTAGTGC
ATATGAGTTATTTCACGATGTAGGTCTTGCTAGCTCTAAGTCAGAGGCACGCAAGCTTATAAGAGGGAAGGGTGCTAAGA
TAAATGATAAATTAGTCGAAGATGAGAATATTATAATTAATACTACTTTCTTACTCGATAAAAATGCTATAAAACTCTCT
GCTGGCAAGAAAAGACATATATTGGTTAGGGTTTAA

Upstream 100 bases:

>100_bases
TGTGCCGTTTGTAGAATAAGATGAAGACACTGTTTTCCTTAAGACTTTATTATTTAGTAGAAAAGCAAAAAAGGAATTGT
TAAAAGATAAGAAATAATAT

Downstream 100 bases:

>100_bases
ATATTTTTCTAGATTGCCATACTCCTTTCAATTGCAACATTGTTGTATGGCTCAGATATATTATGTCTAATTGCAACTGC
AACTTTCAATTAGACAAATT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSFIEEFINKGYFHQCTDLDRLTTITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQRHGHKPIVIIGGGTSKIGDPT
WKDEARKILSKEDIAKNAKGIKKSLSKFIKFGDGKSDAIMFDNVEWLDSLNYLEFLRDFGVHFSINRMLTMDSVKLRLER
EQHLSFLEFNYMLLQAYDFYYLSKHYNCSLQLGGSDQWGNIVMGADLIRKISRKEVFGMTTPLLTTSSGAKMGKTAAGAV
WLNEDLLSPYDYYQYWRNCEDADVIRFAKLYSELTSEELNEFERLAAEDINAAKKKLAYELTKLCHSEQAAKSALETAVK
IFEQGEIDESLPTVVLEQALLQTGISAYELFHDVGLASSKSEARKLIRGKGAKINDKLVEDENIIINTTFLLDKNAIKLS
AGKKRHILVRV

Sequences:

>Translated_411_residues
MSFIEEFINKGYFHQCTDLDRLTTITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQRHGHKPIVIIGGGTSKIGDPT
WKDEARKILSKEDIAKNAKGIKKSLSKFIKFGDGKSDAIMFDNVEWLDSLNYLEFLRDFGVHFSINRMLTMDSVKLRLER
EQHLSFLEFNYMLLQAYDFYYLSKHYNCSLQLGGSDQWGNIVMGADLIRKISRKEVFGMTTPLLTTSSGAKMGKTAAGAV
WLNEDLLSPYDYYQYWRNCEDADVIRFAKLYSELTSEELNEFERLAAEDINAAKKKLAYELTKLCHSEQAAKSALETAVK
IFEQGEIDESLPTVVLEQALLQTGISAYELFHDVGLASSKSEARKLIRGKGAKINDKLVEDENIIINTTFLLDKNAIKLS
AGKKRHILVRV
>Mature_410_residues
SFIEEFINKGYFHQCTDLDRLTTITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQRHGHKPIVIIGGGTSKIGDPTW
KDEARKILSKEDIAKNAKGIKKSLSKFIKFGDGKSDAIMFDNVEWLDSLNYLEFLRDFGVHFSINRMLTMDSVKLRLERE
QHLSFLEFNYMLLQAYDFYYLSKHYNCSLQLGGSDQWGNIVMGADLIRKISRKEVFGMTTPLLTTSSGAKMGKTAAGAVW
LNEDLLSPYDYYQYWRNCEDADVIRFAKLYSELTSEELNEFERLAAEDINAAKKKLAYELTKLCHSEQAAKSALETAVKI
FEQGEIDESLPTVVLEQALLQTGISAYELFHDVGLASSKSEARKLIRGKGAKINDKLVEDENIIINTTFLLDKNAIKLSA
GKKRHILVRV

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=412, Percent_Identity=33.495145631068, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1787925, Length=428, Percent_Identity=39.7196261682243, Blast_Score=294, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI25145802, Length=343, Percent_Identity=32.3615160349854, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI25145805, Length=280, Percent_Identity=29.6428571428571, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6325160, Length=441, Percent_Identity=31.9727891156463, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI20130383, Length=436, Percent_Identity=32.7981651376147, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46592; Mature: 46461

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIEEFINKGYFHQCTDLDRLTTITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQR
CCHHHHHHCCCCCHHHCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
HGHKPIVIIGGGTSKIGDPTWKDEARKILSKEDIAKNAKGIKKSLSKFIKFGDGKSDAIM
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
FDNVEWLDSLNYLEFLRDFGVHFSINRMLTMDSVKLRLEREQHLSFLEFNYMLLQAYDFY
ECCHHHHHHHHHHHHHHHCCCEEEECCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YLSKHYNCSLQLGGSDQWGNIVMGADLIRKISRKEVFGMTTPLLTTSSGAKMGKTAAGAV
EEECCCCEEEEECCCCCCCCEEECHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEE
WLNEDLLSPYDYYQYWRNCEDADVIRFAKLYSELTSEELNEFERLAAEDINAAKKKLAYE
EECHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKLCHSEQAAKSALETAVKIFEQGEIDESLPTVVLEQALLQTGISAYELFHDVGLASSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCH
SEARKLIRGKGAKINDKLVEDENIIINTTFLLDKNAIKLSAGKKRHILVRV
HHHHHHHHCCCCCCCCCEECCCCEEEEEEEEEECCCEEECCCCCCEEEEEC
>Mature Secondary Structure 
SFIEEFINKGYFHQCTDLDRLTTITKETKIAAYIGFDCTATSLHIGSLMQIMILRLLQR
CHHHHHHCCCCCHHHCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
HGHKPIVIIGGGTSKIGDPTWKDEARKILSKEDIAKNAKGIKKSLSKFIKFGDGKSDAIM
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
FDNVEWLDSLNYLEFLRDFGVHFSINRMLTMDSVKLRLEREQHLSFLEFNYMLLQAYDFY
ECCHHHHHHHHHHHHHHHCCCEEEECCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YLSKHYNCSLQLGGSDQWGNIVMGADLIRKISRKEVFGMTTPLLTTSSGAKMGKTAAGAV
EEECCCCEEEEECCCCCCCCEEECHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEE
WLNEDLLSPYDYYQYWRNCEDADVIRFAKLYSELTSEELNEFERLAAEDINAAKKKLAYE
EECHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTKLCHSEQAAKSALETAVKIFEQGEIDESLPTVVLEQALLQTGISAYELFHDVGLASSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCH
SEARKLIRGKGAKINDKLVEDENIIINTTFLLDKNAIKLSAGKKRHILVRV
HHHHHHHHCCCCCCCCCEECCCCEEEEEEEEEECCCEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA