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The map label for this gene is pepQ [H]

Identifier: 157825844

GI number: 157825844

Start: 701788

End: 703605

Strand: Reverse

Name: pepQ [H]

Synonym: A1C_03915

Alternate gene names: 157825844

Gene position: 703605-701788 (Counterclockwise)

Preceding gene: 157825845

Following gene: 157825841

Centisome position: 57.15

GC content: 33.06

Gene sequence:

>1818_bases
ATGACAAAAACCCGCATTAATCTACTTAGAAGCTTATTCACAGAATATGATATAGACAGTTATATAATTCCGTCTAACGA
TAAGTATATGAGCGAATATGTACCTGAGTATGCCAAAAGGCTTGAATATATAACAGGTTTTACCGGTTCAAACGGTATAG
TTATTATATGTAAAGATACAGCATTATTCTTTACCGACGGGCGTTATTTAGAGCAAGCAAATAAAGAGCTGGATTTAGAG
CTTTTTAAGATTTTTGACTTAAAAGATATATCCACAACCTTAAATAAAGATAGCAGAGTAGGATATGATCCTCAATTATT
TACTTGTCCAGCTATATCAAATTTAAAGCTCAATTTTCAAAAGATTAACGGAAATTTAGTTGATAAAATTTGGCATAATC
AGCCATCAGAGCCAAACTCTAAAGTTTATTTACATGATATTAAATTTGCGGGTGCTAGTCATAATGATAAAATAAATAAA
TGTCGTAAAACCTTATTGTCATCCCGCGGCTTGACCGCGGGATCCAGTAATTATAATGAGCAATATGCTCTAATCATTCT
CGATAGCTCATACATATGTTGGTTACTAAATTTGCGTGCTAGTGACGTTGCTTATACACCTTTGATGTTTGCAAAAGTAA
TCGTTACGTCTACAAAATTATATCTATTTATTGATCTCATAAGAATTGATGCCGAAATTATTAATGCACGTCCTGAAATA
ACAATTTTACCGGAAGAAGAATTTGGAAATATTTTAAAGGGTCATGACAATATTTTTGTTGATGATACTATAGCCTCTGT
GCATATAATGGACTTAATAGCTGATAAAAAAGTACAAAAAATTACCGATCCATGTTTAACGCTTAAAGCTTGTAAGAACG
ATATCGAAATTAAGCATGCAATCGATTTTCATATTAAAGATGCAGTAGCTTTATGTGAGTTTTTTGCTGATTTGGCTCAA
TGTCATCTTCGTGAAAATATGGATCTAGAAAAACATAATATGGATTCCAGCTTTCGCAGGAATGACATATGGGATCATGA
GCATGACGAATTGAATGAGTATTCCCTAGGTTTAAAACTTACAGAGTATCGAGCTAAACAAGAGGGCTATGTTTCGGATA
GTTTTCCTGCTATTTGCGGATTTCAGGAGAATAGTGCCATTATTCATTATAGAGCTGTTTTGGAAAATGCTAAAAAAATT
ATAGGGCATGGGATATTACTGATAGATTCCGGCGGTCAATATAGTGGTGCTACTACCGATATAACAAGGACAATCATGAT
AGGTACGCCGACTGATGAGCAGAAAAAGCGTTATACGCAAGTACTTAAAGGACATATTGCTTTAGCTAAAGCCAAATTCC
CAAAAAATATCATCACAGGAGCTAATCTTGATATACTAGCTAGGCAATATTTATGGCAAGACATGCTAGATTATCCACAC
GGTACAGGGCATGGAGTAGGGAGTTTCTTGAGTGTTCATGAAGGACCCCAAAGCATAAATCTTCGTAATAGAACTGTACT
TCAAAAAGGTATGATTCTATCTAACGAACCTGGTTTTTATATTCCTGGCAAATACGGAATTAGAATAGAAAATTTAATGT
ATGTAAAAGAAAATAGCGGATGGCTTGAATTTGAAACCTTAAGCCTAGTACCTTATGATAGTAAATTGATTGATACGAAA
CTACTTAATATTGATGAAATAAATTATATTAAGGAATATTATAACAAAATTAGAGCTAAAATTTATGATTTATTATCTCC
GCAGGCGAGGGGTTGGCTTAACAATGAAATAAATTTATTTTTACAATCATTATTGTAA

Upstream 100 bases:

>100_bases
GGTATTCCTTTATATTATGGGTGGTATAGAGGGAGGAATAGAACTAAATTGTAGCCTGTTGTCATACCGTGGCTTGATCA
CGGTATGACAGGTAGTGAAT

Downstream 100 bases:

>100_bases
TTGACGTTCCCGCTATTTATTGGTATAAAGCCTATACATTCTAATTTATACAATGGGACGTCGCCAAGTGGTAAGGCAAC
GGTTTTTGGTATCGTCATTC

Product: aminopeptidase P

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MTKTRINLLRSLFTEYDIDSYIIPSNDKYMSEYVPEYAKRLEYITGFTGSNGIVIICKDTALFFTDGRYLEQANKELDLE
LFKIFDLKDISTTLNKDSRVGYDPQLFTCPAISNLKLNFQKINGNLVDKIWHNQPSEPNSKVYLHDIKFAGASHNDKINK
CRKTLLSSRGLTAGSSNYNEQYALIILDSSYICWLLNLRASDVAYTPLMFAKVIVTSTKLYLFIDLIRIDAEIINARPEI
TILPEEEFGNILKGHDNIFVDDTIASVHIMDLIADKKVQKITDPCLTLKACKNDIEIKHAIDFHIKDAVALCEFFADLAQ
CHLRENMDLEKHNMDSSFRRNDIWDHEHDELNEYSLGLKLTEYRAKQEGYVSDSFPAICGFQENSAIIHYRAVLENAKKI
IGHGILLIDSGGQYSGATTDITRTIMIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIITGANLDILARQYLWQDMLDYPH
GTGHGVGSFLSVHEGPQSINLRNRTVLQKGMILSNEPGFYIPGKYGIRIENLMYVKENSGWLEFETLSLVPYDSKLIDTK
LLNIDEINYIKEYYNKIRAKIYDLLSPQARGWLNNEINLFLQSLL

Sequences:

>Translated_605_residues
MTKTRINLLRSLFTEYDIDSYIIPSNDKYMSEYVPEYAKRLEYITGFTGSNGIVIICKDTALFFTDGRYLEQANKELDLE
LFKIFDLKDISTTLNKDSRVGYDPQLFTCPAISNLKLNFQKINGNLVDKIWHNQPSEPNSKVYLHDIKFAGASHNDKINK
CRKTLLSSRGLTAGSSNYNEQYALIILDSSYICWLLNLRASDVAYTPLMFAKVIVTSTKLYLFIDLIRIDAEIINARPEI
TILPEEEFGNILKGHDNIFVDDTIASVHIMDLIADKKVQKITDPCLTLKACKNDIEIKHAIDFHIKDAVALCEFFADLAQ
CHLRENMDLEKHNMDSSFRRNDIWDHEHDELNEYSLGLKLTEYRAKQEGYVSDSFPAICGFQENSAIIHYRAVLENAKKI
IGHGILLIDSGGQYSGATTDITRTIMIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIITGANLDILARQYLWQDMLDYPH
GTGHGVGSFLSVHEGPQSINLRNRTVLQKGMILSNEPGFYIPGKYGIRIENLMYVKENSGWLEFETLSLVPYDSKLIDTK
LLNIDEINYIKEYYNKIRAKIYDLLSPQARGWLNNEINLFLQSLL
>Mature_604_residues
TKTRINLLRSLFTEYDIDSYIIPSNDKYMSEYVPEYAKRLEYITGFTGSNGIVIICKDTALFFTDGRYLEQANKELDLEL
FKIFDLKDISTTLNKDSRVGYDPQLFTCPAISNLKLNFQKINGNLVDKIWHNQPSEPNSKVYLHDIKFAGASHNDKINKC
RKTLLSSRGLTAGSSNYNEQYALIILDSSYICWLLNLRASDVAYTPLMFAKVIVTSTKLYLFIDLIRIDAEIINARPEIT
ILPEEEFGNILKGHDNIFVDDTIASVHIMDLIADKKVQKITDPCLTLKACKNDIEIKHAIDFHIKDAVALCEFFADLAQC
HLRENMDLEKHNMDSSFRRNDIWDHEHDELNEYSLGLKLTEYRAKQEGYVSDSFPAICGFQENSAIIHYRAVLENAKKII
GHGILLIDSGGQYSGATTDITRTIMIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIITGANLDILARQYLWQDMLDYPHG
TGHGVGSFLSVHEGPQSINLRNRTVLQKGMILSNEPGFYIPGKYGIRIENLMYVKENSGWLEFETLSLVPYDSKLIDTKL
LNIDEINYIKEYYNKIRAKIYDLLSPQARGWLNNEINLFLQSLL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=633, Percent_Identity=34.4391785150079, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI93141226, Length=611, Percent_Identity=30.9328968903437, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI264681565, Length=633, Percent_Identity=33.0173775671406, Blast_Score=284, Evalue=2e-76,
Organism=Homo sapiens, GI149589008, Length=206, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI260593665, Length=243, Percent_Identity=28.3950617283951, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788728, Length=193, Percent_Identity=30.0518134715026, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=633, Percent_Identity=31.5955766192733, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI25149105, Length=637, Percent_Identity=27.6295133437991, Blast_Score=242, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6322999, Length=677, Percent_Identity=33.0871491875923, Blast_Score=310, Evalue=5e-85,
Organism=Drosophila melanogaster, GI17137632, Length=639, Percent_Identity=32.7073552425665, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI161078230, Length=617, Percent_Identity=28.2009724473258, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21357287, Length=617, Percent_Identity=28.2009724473258, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 69128; Mature: 68997

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTRINLLRSLFTEYDIDSYIIPSNDKYMSEYVPEYAKRLEYITGFTGSNGIVIICKDT
CCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCEECCCCEEEEEECC
ALFFTDGRYLEQANKELDLELFKIFDLKDISTTLNKDSRVGYDPQLFTCPAISNLKLNFQ
EEEEECCHHHHHCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEE
KINGNLVDKIWHNQPSEPNSKVYLHDIKFAGASHNDKINKCRKTLLSSRGLTAGSSNYNE
EECCCHHHHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
QYALIILDSSYICWLLNLRASDVAYTPLMFAKVIVTSTKLYLFIDLIRIDAEIINARPEI
EEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHCCCCCE
TILPEEEFGNILKGHDNIFVDDTIASVHIMDLIADKKVQKITDPCLTLKACKNDIEIKHA
EEECCHHHCCHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IDFHIKDAVALCEFFADLAQCHLRENMDLEKHNMDSSFRRNDIWDHEHDELNEYSLGLKL
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEE
TEYRAKQEGYVSDSFPAICGFQENSAIIHYRAVLENAKKIIGHGILLIDSGGQYSGATTD
EHHHCCCCCCCCCCCCEEECCCCCCEEEEHHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
ITRTIMIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIITGANLDILARQYLWQDMLDYPH
EEEEEEEECCCCHHHHHHHHHHHHHHHEEHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCC
GTGHGVGSFLSVHEGPQSINLRNRTVLQKGMILSNEPGFYIPGKYGIRIENLMYVKENSG
CCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCEEECCCCEEECCCCCEEEEEEEEEECCCC
WLEFETLSLVPYDSKLIDTKLLNIDEINYIKEYYNKIRAKIYDLLSPQARGWLNNEINLF
EEEEEEEEECCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHH
LQSLL
HHHHC
>Mature Secondary Structure 
TKTRINLLRSLFTEYDIDSYIIPSNDKYMSEYVPEYAKRLEYITGFTGSNGIVIICKDT
CCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCEECCCCEEEEEECC
ALFFTDGRYLEQANKELDLELFKIFDLKDISTTLNKDSRVGYDPQLFTCPAISNLKLNFQ
EEEEECCHHHHHCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEEE
KINGNLVDKIWHNQPSEPNSKVYLHDIKFAGASHNDKINKCRKTLLSSRGLTAGSSNYNE
EECCCHHHHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
QYALIILDSSYICWLLNLRASDVAYTPLMFAKVIVTSTKLYLFIDLIRIDAEIINARPEI
EEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHCCCCCE
TILPEEEFGNILKGHDNIFVDDTIASVHIMDLIADKKVQKITDPCLTLKACKNDIEIKHA
EEECCHHHCCHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IDFHIKDAVALCEFFADLAQCHLRENMDLEKHNMDSSFRRNDIWDHEHDELNEYSLGLKL
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEE
TEYRAKQEGYVSDSFPAICGFQENSAIIHYRAVLENAKKIIGHGILLIDSGGQYSGATTD
EHHHCCCCCCCCCCCCEEECCCCCCEEEEHHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
ITRTIMIGTPTDEQKKRYTQVLKGHIALAKAKFPKNIITGANLDILARQYLWQDMLDYPH
EEEEEEEECCCCHHHHHHHHHHHHHHHEEHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCC
GTGHGVGSFLSVHEGPQSINLRNRTVLQKGMILSNEPGFYIPGKYGIRIENLMYVKENSG
CCCCCCHHHHHHCCCCCCCCCCHHHHHHCCCEEECCCCEEECCCCCEEEEEEEEEECCCC
WLEFETLSLVPYDSKLIDTKLLNIDEINYIKEYYNKIRAKIYDLLSPQARGWLNNEINLF
EEEEEEEEECCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHH
LQSLL
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]