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The map label for this gene is adiC [H]

Identifier: 157825845

GI number: 157825845

Start: 703652

End: 704998

Strand: Reverse

Name: adiC [H]

Synonym: A1C_03920

Alternate gene names: 157825845

Gene position: 704998-703652 (Counterclockwise)

Preceding gene: 157825846

Following gene: 157825844

Centisome position: 57.27

GC content: 35.41

Gene sequence:

>1347_bases
TTGCTAAAAATTATTATTTCAGCTATTTTAAAGCTATTTACTTTAAATCAAATTATTATGTCGCAAAAATTAGGTTTCTG
GGCGGTTTTTGCCTTAGTAACCGGCAGTCAAATCGGTACTAGCGTTTTTATATTACCGCTAAGTTTAGCACCGTTCGGTA
TATATAGCGTTTGGGGCTGGGTACTTTCATTATTCGGTGCTATGAGTATAGCCCTGGTATTCTCATTCTTATGTGCACAA
TTTCCTAAAACAGGCGGTCCTCATGTTTATGTACGAGAGAGTTTTGGGGATACAATAGCTTTCTTCACCGGTTTCACTTA
CTGGGTTATATCCTTTGTCAGTACAAGTATAGTGGTCATTTCGGCGATAGGTTATCTAACGCCTTTTTTTCAATCACAAA
CGATTTTGGATTTAATATTACAGATAATATTATTAACTGCTATTGCAATTTTAAATTTAAAAGGTCCTGAAGTAGCAGGA
AAAGCAGAGTTTTATTTGACTCTCTTAAAATTTGTTCCGCTGCTTGTAGTAGGTTTAGCTGCATTATCTCATTTTAATAT
AGATAATATAGTTATTGCTAAGGAAGTAGAGAATTTAAGTATTCCGACTATTATTGGAAGAGTTGCACTGCTTACTTTTT
GGGGATTTATTGGGGTAGAGTGTGCAACTACTACGGCAGGAGCAGTAAAAGATCCGGCAACAACTATTCCAAAAGCCATA
ATAGTTGGCACTTTTTGCGTATCGGGGTTATATATTATTAATAGTATAGGTATAATGGGATTAATCCCTGCTTCTGAACT
TATTAATTCTAAAGCTCCTTATGCCGATGCCGCTGCATTATTGTTCGGTGGTAAATGGTCAAGCGTAATTGCAGTTATAG
CCTCGATTATATGTATAGGTACGCTCAACGCTTGGGTTCTGACTAGCGGACAGATTGCTCTAGGACTTGCAGAAGACGGG
TTATTGCCAAAATTTTTTGCTAAGAAAAATAGCAATAACGCCCCAACTTACGGAATTATTCTAAGTTGCCTTGGCATTGT
GCCATTATTAGCCTTTACGTCAAATGATAATTTTGCCGAGCAGATTACGCAAATAATAGATTTTTCGGTAATAGCATTTT
TGTTTGTTTATTTAATTTGTAGCTTAGCTTCCTTCAAGGTAATTCGTAGTTCAAAGGAAAAATTTTCTTCTTATTATTTA
CTTATAGCCCTAATATCGATTATCTTTTGTGCATGGGTTATCTATGCAACACCTGTTAAAACTCTAATTATAGCTTGTTC
ATTCACTATATCAGGTATTCCTTTATATTATGGGTGGTATAGAGGGAGGAATAGAACTAAATTGTAG

Upstream 100 bases:

>100_bases
CTTGGTATATTAACTCCTAAGATTATTTTTGATAGCTAAAAAAAGCTATCAATCTTTTGTTTAGAAATCAATAGTCAAAT
AGTTATAGTAGTTTTAACTA

Downstream 100 bases:

>100_bases
CCTGTTGTCATACCGTGGCTTGATCACGGTATGACAGGTAGTGAATATGACAAAAACCCGCATTAATCTACTTAGAAGCT
TATTCACAGAATATGATATA

Product: putrescine-ornithine antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLKIIISAILKLFTLNQIIMSQKLGFWAVFALVTGSQIGTSVFILPLSLAPFGIYSVWGWVLSLFGAMSIALVFSFLCAQ
FPKTGGPHVYVRESFGDTIAFFTGFTYWVISFVSTSIVVISAIGYLTPFFQSQTILDLILQIILLTAIAILNLKGPEVAG
KAEFYLTLLKFVPLLVVGLAALSHFNIDNIVIAKEVENLSIPTIIGRVALLTFWGFIGVECATTTAGAVKDPATTIPKAI
IVGTFCVSGLYIINSIGIMGLIPASELINSKAPYADAAALLFGGKWSSVIAVIASIICIGTLNAWVLTSGQIALGLAEDG
LLPKFFAKKNSNNAPTYGIILSCLGIVPLLAFTSNDNFAEQITQIIDFSVIAFLFVYLICSLASFKVIRSSKEKFSSYYL
LIALISIIFCAWVIYATPVKTLIIACSFTISGIPLYYGWYRGRNRTKL

Sequences:

>Translated_448_residues
MLKIIISAILKLFTLNQIIMSQKLGFWAVFALVTGSQIGTSVFILPLSLAPFGIYSVWGWVLSLFGAMSIALVFSFLCAQ
FPKTGGPHVYVRESFGDTIAFFTGFTYWVISFVSTSIVVISAIGYLTPFFQSQTILDLILQIILLTAIAILNLKGPEVAG
KAEFYLTLLKFVPLLVVGLAALSHFNIDNIVIAKEVENLSIPTIIGRVALLTFWGFIGVECATTTAGAVKDPATTIPKAI
IVGTFCVSGLYIINSIGIMGLIPASELINSKAPYADAAALLFGGKWSSVIAVIASIICIGTLNAWVLTSGQIALGLAEDG
LLPKFFAKKNSNNAPTYGIILSCLGIVPLLAFTSNDNFAEQITQIIDFSVIAFLFVYLICSLASFKVIRSSKEKFSSYYL
LIALISIIFCAWVIYATPVKTLIIACSFTISGIPLYYGWYRGRNRTKL
>Mature_448_residues
MLKIIISAILKLFTLNQIIMSQKLGFWAVFALVTGSQIGTSVFILPLSLAPFGIYSVWGWVLSLFGAMSIALVFSFLCAQ
FPKTGGPHVYVRESFGDTIAFFTGFTYWVISFVSTSIVVISAIGYLTPFFQSQTILDLILQIILLTAIAILNLKGPEVAG
KAEFYLTLLKFVPLLVVGLAALSHFNIDNIVIAKEVENLSIPTIIGRVALLTFWGFIGVECATTTAGAVKDPATTIPKAI
IVGTFCVSGLYIINSIGIMGLIPASELINSKAPYADAAALLFGGKWSSVIAVIASIICIGTLNAWVLTSGQIALGLAEDG
LLPKFFAKKNSNNAPTYGIILSCLGIVPLLAFTSNDNFAEQITQIIDFSVIAFLFVYLICSLASFKVIRSSKEKFSSYYL
LIALISIIFCAWVIYATPVKTLIIACSFTISGIPLYYGWYRGRNRTKL

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71999149, Length=350, Percent_Identity=23.7142857142857, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI2367353, Length=405, Percent_Identity=27.9012345679012, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786908, Length=427, Percent_Identity=25.2927400468384, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790575, Length=395, Percent_Identity=25.8227848101266, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787890, Length=374, Percent_Identity=25.1336898395722, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082250, Length=458, Percent_Identity=25.764192139738, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790653, Length=382, Percent_Identity=26.4397905759162, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87081915, Length=399, Percent_Identity=24.0601503759398, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790584, Length=376, Percent_Identity=21.5425531914894, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566699, Length=281, Percent_Identity=26.3345195729537, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71995382, Length=371, Percent_Identity=24.7978436657682, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=371, Percent_Identity=24.7978436657682, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21357367, Length=464, Percent_Identity=25, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45550968, Length=471, Percent_Identity=22.2929936305732, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921172, Length=471, Percent_Identity=22.2929936305732, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221331183, Length=456, Percent_Identity=25.219298245614, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647653, Length=456, Percent_Identity=25.219298245614, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664379, Length=456, Percent_Identity=25.219298245614, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48491; Mature: 48491

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIIISAILKLFTLNQIIMSQKLGFWAVFALVTGSQIGTSVFILPLSLAPFGIYSVWGW
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEHHCCCHHHHHHHHH
VLSLFGAMSIALVFSFLCAQFPKTGGPHVYVRESFGDTIAFFTGFTYWVISFVSTSIVVI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SAIGYLTPFFQSQTILDLILQIILLTAIAILNLKGPEVAGKAEFYLTLLKFVPLLVVGLA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALSHFNIDNIVIAKEVENLSIPTIIGRVALLTFWGFIGVECATTTAGAVKDPATTIPKAI
HHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IVGTFCVSGLYIINSIGIMGLIPASELINSKAPYADAAALLFGGKWSSVIAVIASIICIG
HHHHHHHHHHHHHHHCCHHEECCHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
TLNAWVLTSGQIALGLAEDGLLPKFFAKKNSNNAPTYGIILSCLGIVPLLAFTSNDNFAE
CCCHHEEECCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
QITQIIDFSVIAFLFVYLICSLASFKVIRSSKEKFSSYYLLIALISIIFCAWVIYATPVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIIACSFTISGIPLYYGWYRGRNRTKL
HHHHHHHHHCCCCHHEEHEECCCCCCCC
>Mature Secondary Structure
MLKIIISAILKLFTLNQIIMSQKLGFWAVFALVTGSQIGTSVFILPLSLAPFGIYSVWGW
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEHHCCCHHHHHHHHH
VLSLFGAMSIALVFSFLCAQFPKTGGPHVYVRESFGDTIAFFTGFTYWVISFVSTSIVVI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SAIGYLTPFFQSQTILDLILQIILLTAIAILNLKGPEVAGKAEFYLTLLKFVPLLVVGLA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALSHFNIDNIVIAKEVENLSIPTIIGRVALLTFWGFIGVECATTTAGAVKDPATTIPKAI
HHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IVGTFCVSGLYIINSIGIMGLIPASELINSKAPYADAAALLFGGKWSSVIAVIASIICIG
HHHHHHHHHHHHHHHCCHHEECCHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
TLNAWVLTSGQIALGLAEDGLLPKFFAKKNSNNAPTYGIILSCLGIVPLLAFTSNDNFAE
CCCHHEEECCCEEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
QITQIIDFSVIAFLFVYLICSLASFKVIRSSKEKFSSYYLLIALISIIFCAWVIYATPVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIIACSFTISGIPLYYGWYRGRNRTKL
HHHHHHHHHCCCCHHEEHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]