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The map label for this gene is murC [H]

Identifier: 157825459

GI number: 157825459

Start: 335513

End: 336949

Strand: Direct

Name: murC [H]

Synonym: A1C_01800

Alternate gene names: 157825459

Gene position: 335513-336949 (Clockwise)

Preceding gene: 157825458

Following gene: 157825460

Centisome position: 27.25

GC content: 33.54

Gene sequence:

>1437_bases
ATGCTGTTACTTGAATTAAAAAAAACTAATCAAACTTTAGAAACTATACATTTTCTAGGTATCGGCGGCGTTGGAATGAG
TGGTATTGCCGAGATATTACATAATCTAGGTTATAAAGTACAAGGTTCCGATTTAGTAGAAAATTATAATACTAAAAGAC
TTGAGTCATACGGTATTAAAATATTTTTAGGACATGCTAAGCAGCACATTACCAATGTTTCGTATGTTGTTATTTCATCG
GCAATTAATTCAAATAATCCTGAAATCAAAGAGGCATTAGAGCGTAAAATTCCGATTATTAGGCGTGCGGAAATGCTCGC
GGAACTTATGAGGTTAAAATGTTCTGTAGCAGTGTCTGGATCGCACGGCAAAACAACTACTACTTCTTTAATGGCTTGTT
TATTTGAGGCAGCCGGTTTATGTCCTACAGTTATTAACGGCGGGATTATAAATAATAAATCGACTAATGCATATCTTGGT
TCAAGTAATTATTTAATTGCGGAGGCCGATGAATCGGATGCGACGTTTATTCATATTCCATCAACTATTGCGATAATAAC
TAACATTGACCCTGAACATTTAGATTATTATAAAGATTTTGAAACATTAATTGGTGCATTTAAAAGCTTTATTACTAATT
TGCCGTTTTACGGTTTTGCCGTTTGTTGTATCGATCATACAATAGTTCGTAAGTTAGTAGATGATATTACTGAAAGGAAG
ATTGTTACTTATGGAATCGATTCAGAAGATGCCCATATTATAGCGTTTAATATTAACACTGATATTGCTTCCTCTACTTT
TGACGTAAAAATTAATATACCAAATGTACTAGGTACAACGATTATTGAAAAAATTACCATTCCAACGCCCGGAAGACATA
ATATTTTAAATAGTCTTGCTGCAATTGCCGTTGGGATAGAATTAGATTTCGGTATTAAAGCTATTAAAAACGGTTTTAAT
AATTTTAAAGGAGTGAAAAGGAGATTTACTAAAGTAGCTGAATATAATAATGCGGTGGTTATCGATGATTACGCTCATCA
TCCTGAGGAAATCAAAGCGACGCTTGCTACGGCTCGAAATATAGCCGATAAGCAAAACGGTAAAGTTATTGCTATTTTTC
AGCCTCATAGATATTCAAGGATGCAGCATTTATTTGATGATTTTATGCGTTGTTTTAATGATGCAGATATGATTTATATT
ACCGATATATATGCTGCAGGAGAAGAGCCTATAGAAGGGGTTACAGGTCAAAATTTAGTTGATAAGATTACTAAAAATAA
GCATCATGACCAAGCAAATTTTTTAGCTGAATTAGAGGATGTAGTTGGCGTTATTATAGATAATGCAGCTTCCGGTGATA
TGATAATTATTATGGGAGCAGGTAATATTTCAAGTTTTGCTAATGAATTAGATGAGAGATTGTCATCCCGCACTTGA

Upstream 100 bases:

>100_bases
TGTCATTCCCACCTACGCTGGCATGACATACGAAGTATAATACTTGACAATCTACATAAAAACCTCTATGCAGAACTCAA
CTTTCAATAATTAAACTTAG

Downstream 100 bases:

>100_bases
TATCCATGAAACAACGTCATAGAAGAAAAAAGATGAAAGTAAAAATATGTTAATTTTACCGACAGTAAAGGGCGAGTATC
AAAAAGATTATAATTTAAAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MLLLELKKTNQTLETIHFLGIGGVGMSGIAEILHNLGYKVQGSDLVENYNTKRLESYGIKIFLGHAKQHITNVSYVVISS
AINSNNPEIKEALERKIPIIRRAEMLAELMRLKCSVAVSGSHGKTTTTSLMACLFEAAGLCPTVINGGIINNKSTNAYLG
SSNYLIAEADESDATFIHIPSTIAIITNIDPEHLDYYKDFETLIGAFKSFITNLPFYGFAVCCIDHTIVRKLVDDITERK
IVTYGIDSEDAHIIAFNINTDIASSTFDVKINIPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGIKAIKNGFN
NFKGVKRRFTKVAEYNNAVVIDDYAHHPEEIKATLATARNIADKQNGKVIAIFQPHRYSRMQHLFDDFMRCFNDADMIYI
TDIYAAGEEPIEGVTGQNLVDKITKNKHHDQANFLAELEDVVGVIIDNAASGDMIIIMGAGNISSFANELDERLSSRT

Sequences:

>Translated_478_residues
MLLLELKKTNQTLETIHFLGIGGVGMSGIAEILHNLGYKVQGSDLVENYNTKRLESYGIKIFLGHAKQHITNVSYVVISS
AINSNNPEIKEALERKIPIIRRAEMLAELMRLKCSVAVSGSHGKTTTTSLMACLFEAAGLCPTVINGGIINNKSTNAYLG
SSNYLIAEADESDATFIHIPSTIAIITNIDPEHLDYYKDFETLIGAFKSFITNLPFYGFAVCCIDHTIVRKLVDDITERK
IVTYGIDSEDAHIIAFNINTDIASSTFDVKINIPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGIKAIKNGFN
NFKGVKRRFTKVAEYNNAVVIDDYAHHPEEIKATLATARNIADKQNGKVIAIFQPHRYSRMQHLFDDFMRCFNDADMIYI
TDIYAAGEEPIEGVTGQNLVDKITKNKHHDQANFLAELEDVVGVIIDNAASGDMIIIMGAGNISSFANELDERLSSRT
>Mature_478_residues
MLLLELKKTNQTLETIHFLGIGGVGMSGIAEILHNLGYKVQGSDLVENYNTKRLESYGIKIFLGHAKQHITNVSYVVISS
AINSNNPEIKEALERKIPIIRRAEMLAELMRLKCSVAVSGSHGKTTTTSLMACLFEAAGLCPTVINGGIINNKSTNAYLG
SSNYLIAEADESDATFIHIPSTIAIITNIDPEHLDYYKDFETLIGAFKSFITNLPFYGFAVCCIDHTIVRKLVDDITERK
IVTYGIDSEDAHIIAFNINTDIASSTFDVKINIPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGIKAIKNGFN
NFKGVKRRFTKVAEYNNAVVIDDYAHHPEEIKATLATARNIADKQNGKVIAIFQPHRYSRMQHLFDDFMRCFNDADMIYI
TDIYAAGEEPIEGVTGQNLVDKITKNKHHDQANFLAELEDVVGVIIDNAASGDMIIIMGAGNISSFANELDERLSSRT

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=474, Percent_Identity=40.084388185654, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=26.0416666666667, Blast_Score=161, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52688; Mature: 52688

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLELKKTNQTLETIHFLGIGGVGMSGIAEILHNLGYKVQGSDLVENYNTKRLESYGIK
CEEEEEECCCCHHHHHHEEEECCCCHHHHHHHHHHCCCEECCCHHHHCCCHHHHHHCCEE
IFLGHAKQHITNVSYVVISSAINSNNPEIKEALERKIPIIRRAEMLAELMRLKCSVAVSG
EEEECHHHHHCCHHEEEEEHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEC
SHGKTTTTSLMACLFEAAGLCPTVINGGIINNKSTNAYLGSSNYLIAEADESDATFIHIP
CCCCHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCEEECCCCEEEEECCCCCCEEEECC
STIAIITNIDPEHLDYYKDFETLIGAFKSFITNLPFYGFAVCCIDHTIVRKLVDDITERK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCE
IVTYGIDSEDAHIIAFNINTDIASSTFDVKINIPNVLGTTIIEKITIPTPGRHNILNSLA
EEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCCHHHHHHHHH
AIAVGIELDFGIKAIKNGFNNFKGVKRRFTKVAEYNNAVVIDDYAHHPEEIKATLATARN
HHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
IADKQNGKVIAIFQPHRYSRMQHLFDDFMRCFNDADMIYITDIYAAGEEPIEGVTGQNLV
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHH
DKITKNKHHDQANFLAELEDVVGVIIDNAASGDMIIIMGAGNISSFANELDERLSSRT
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLLLELKKTNQTLETIHFLGIGGVGMSGIAEILHNLGYKVQGSDLVENYNTKRLESYGIK
CEEEEEECCCCHHHHHHEEEECCCCHHHHHHHHHHCCCEECCCHHHHCCCHHHHHHCCEE
IFLGHAKQHITNVSYVVISSAINSNNPEIKEALERKIPIIRRAEMLAELMRLKCSVAVSG
EEEECHHHHHCCHHEEEEEHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEC
SHGKTTTTSLMACLFEAAGLCPTVINGGIINNKSTNAYLGSSNYLIAEADESDATFIHIP
CCCCHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCEEECCCCEEEEECCCCCCEEEECC
STIAIITNIDPEHLDYYKDFETLIGAFKSFITNLPFYGFAVCCIDHTIVRKLVDDITERK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCE
IVTYGIDSEDAHIIAFNINTDIASSTFDVKINIPNVLGTTIIEKITIPTPGRHNILNSLA
EEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCCHHHHHHHHH
AIAVGIELDFGIKAIKNGFNNFKGVKRRFTKVAEYNNAVVIDDYAHHPEEIKATLATARN
HHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
IADKQNGKVIAIFQPHRYSRMQHLFDDFMRCFNDADMIYITDIYAAGEEPIEGVTGQNLV
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHHH
DKITKNKHHDQANFLAELEDVVGVIIDNAASGDMIIIMGAGNISSFANELDERLSSRT
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA