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The map label for this gene is murB

Identifier: 157825460

GI number: 157825460

Start: 336996

End: 337883

Strand: Direct

Name: murB

Synonym: A1C_01805

Alternate gene names: 157825460

Gene position: 336996-337883 (Clockwise)

Preceding gene: 157825459

Following gene: 157825461

Centisome position: 27.37

GC content: 33.56

Gene sequence:

>888_bases
ATGTTAATTTTACCGACAGTAAAGGGCGAGTATCAAAAAGATTATAATTTAAAACATCTGACATGGTTTAAAGTAGGCGG
TGATGCTGAAATTTTCTTTAAACCTTTAGATAGCGAAGATTTAGCAAGTTTCTTAATACAAAATAGACAAAAATTACCTA
TAACTACTTTTGGTGCAGGCTCAAATATTATTATAAGAGACGGCGGCATAGAAGGGGTCGTTATAAAACTTGGTCAGAAT
TTTAGTAATATTGAGTTTATAGATAATCATTTAATAGTAGGTAGCAGCTGTCTTAATTATAATTTAGCAAAATTCTGTCA
AGCAAATGATATTTCCGGTTTTGAGTTTTTAGTAGGTATTCCTGGTACTATCGGTGGTGGTGTTGCTATGAATGCCGGAG
CTTACGGTTCTGAATTTAAAGATATTATAGTTAGAATAGAAGCTATTGACTTTGCAGGAAATTTTCGAACATTTACTAAT
GCAGAAAGCGGTTTTAAATATCGTGGCAATAATTTACCGAAGGATTTAATTATTCTCAAAGCCGTTTTTAAAGTAAATAA
AGGAGATAGTGAGAATATATTATTACGGATGAATGAAATAAATAACACAAGATCATTGACGCAGCCTATTAAAGAGCGTA
CGGGCGGTAGTACTTTTGCAAATCCTGAAGGGCTTAAATCTTGGGAACTTATTGACAAAGCAGGGCTTAGGGGCTATAGA
ATAGGCGGGGCTTCGATGTCAGAACTTCACTGTAATTTTATGATAAATAATGGTGATGCTACCTCTAAGGATTTAGAAGA
TTTAGGTGATTTTGTTCGGCAGAAAGTATTTGAAGATAGTGGCGTTGAATTAAAGTGGGAAATTAAGATAATAGGGAAGT
ATGTTTAA

Upstream 100 bases:

>100_bases
AATATTTCAAGTTTTGCTAATGAATTAGATGAGAGATTGTCATCCCGCACTTGATATCCATGAAACAACGTCATAGAAGA
AAAAAGATGAAAGTAAAAAT

Downstream 100 bases:

>100_bases
AAACCGTCATTGCGAGCAGTCGTAGACTGCGTGGCAATCCAGTAAAACATGCTAATCTATCGCATGTTTTACTGGATTGC
TTCGTTAAAACTTATAGTTT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLILPTVKGEYQKDYNLKHLTWFKVGGDAEIFFKPLDSEDLASFLIQNRQKLPITTFGAGSNIIIRDGGIEGVVIKLGQN
FSNIEFIDNHLIVGSSCLNYNLAKFCQANDISGFEFLVGIPGTIGGGVAMNAGAYGSEFKDIIVRIEAIDFAGNFRTFTN
AESGFKYRGNNLPKDLIILKAVFKVNKGDSENILLRMNEINNTRSLTQPIKERTGGSTFANPEGLKSWELIDKAGLRGYR
IGGASMSELHCNFMINNGDATSKDLEDLGDFVRQKVFEDSGVELKWEIKIIGKYV

Sequences:

>Translated_295_residues
MLILPTVKGEYQKDYNLKHLTWFKVGGDAEIFFKPLDSEDLASFLIQNRQKLPITTFGAGSNIIIRDGGIEGVVIKLGQN
FSNIEFIDNHLIVGSSCLNYNLAKFCQANDISGFEFLVGIPGTIGGGVAMNAGAYGSEFKDIIVRIEAIDFAGNFRTFTN
AESGFKYRGNNLPKDLIILKAVFKVNKGDSENILLRMNEINNTRSLTQPIKERTGGSTFANPEGLKSWELIDKAGLRGYR
IGGASMSELHCNFMINNGDATSKDLEDLGDFVRQKVFEDSGVELKWEIKIIGKYV
>Mature_295_residues
MLILPTVKGEYQKDYNLKHLTWFKVGGDAEIFFKPLDSEDLASFLIQNRQKLPITTFGAGSNIIIRDGGIEGVVIKLGQN
FSNIEFIDNHLIVGSSCLNYNLAKFCQANDISGFEFLVGIPGTIGGGVAMNAGAYGSEFKDIIVRIEAIDFAGNFRTFTN
AESGFKYRGNNLPKDLIILKAVFKVNKGDSENILLRMNEINNTRSLTQPIKERTGGSTFANPEGLKSWELIDKAGLRGYR
IGGASMSELHCNFMINNGDATSKDLEDLGDFVRQKVFEDSGVELKWEIKIIGKYV

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_RICAH (A8GMP7)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493180.1
- ProteinModelPortal:   A8GMP7
- SMR:   A8GMP7
- STRING:   A8GMP7
- GeneID:   5645118
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_01805
- NMPDR:   fig|293614.3.peg.338
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   RAKA293614:A1C_01805-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32627; Mature: 32627

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 168-168 ACT_SITE 217-217 ACT_SITE 287-287

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILPTVKGEYQKDYNLKHLTWFKVGGDAEIFFKPLDSEDLASFLIQNRQKLPITTFGAG
CEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCEEEECCC
SNIIIRDGGIEGVVIKLGQNFSNIEFIDNHLIVGSSCLNYNLAKFCQANDISGFEFLVGI
CEEEEECCCCCEEEEEECCCCCCEEEECCEEEECCHHHCCCHHHHHCCCCCCCEEEEEEC
PGTIGGGVAMNAGAYGSEFKDIIVRIEAIDFAGNFRTFTNAESGFKYRGNNLPKDLIILK
CCCCCCCEEECCCCCCCHHHEEEEEEEEEEECCCCCEECCCCCCCEECCCCCCHHHHHHH
AVFKVNKGDSENILLRMNEINNTRSLTQPIKERTGGSTFANPEGLKSWELIDKAGLRGYR
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEE
IGGASMSELHCNFMINNGDATSKDLEDLGDFVRQKVFEDSGVELKWEIKIIGKYV
ECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECC
>Mature Secondary Structure
MLILPTVKGEYQKDYNLKHLTWFKVGGDAEIFFKPLDSEDLASFLIQNRQKLPITTFGAG
CEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCEEEECCC
SNIIIRDGGIEGVVIKLGQNFSNIEFIDNHLIVGSSCLNYNLAKFCQANDISGFEFLVGI
CEEEEECCCCCEEEEEECCCCCCEEEECCEEEECCHHHCCCHHHHHCCCCCCCEEEEEEC
PGTIGGGVAMNAGAYGSEFKDIIVRIEAIDFAGNFRTFTNAESGFKYRGNNLPKDLIILK
CCCCCCCEEECCCCCCCHHHEEEEEEEEEEECCCCCEECCCCCCCEECCCCCCHHHHHHH
AVFKVNKGDSENILLRMNEINNTRSLTQPIKERTGGSTFANPEGLKSWELIDKAGLRGYR
HHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEE
IGGASMSELHCNFMINNGDATSKDLEDLGDFVRQKVFEDSGVELKWEIKIIGKYV
ECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA