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The map label for this gene is emrA [H]

Identifier: 157825454

GI number: 157825454

Start: 332191

End: 333243

Strand: Direct

Name: emrA [H]

Synonym: A1C_01775

Alternate gene names: 157825454

Gene position: 332191-333243 (Clockwise)

Preceding gene: 157825453

Following gene: 157825455

Centisome position: 26.98

GC content: 32.38

Gene sequence:

>1053_bases
ATGCCGAGTATATTACAACAAGCCATCGACAAATATACACGTCATCCATTTACTAAATATGTAACTATTATAGCCTTAAT
AATATTTATTTATTTGGGATATAGAATTTATGTTTGGGCAAATACACAATCCACGGATAATGCCTACATAGATGCAGATA
TTTCAAATGTTAGTGCTGAAGTTAGCGGTGTTGTCACAAAGTTATTTGTTACCGATAATACTAAAGTTAATAAAGGTGAT
CTGATAGCTGAAATTGACGATAGAGATTATAAGGCAAAGCTTGCAGCACTTGAAGCATCTATTGAAGCTTGCATAAAAAA
TATAGAAATTATAGAGCAAAAAACCTCAATAGGGCAGATTAGACTAGAACAAGCGGCTGAAAAATTAAAGCTTACTAAAA
TAAGCTTTGATATTGTGTCAACAGATTTTACTAGAGTGCAGGAATTAAATAAGGCAAAATTTGCTAGTTCTAAAACATTA
AATGATTCTAAAAACGCATATCAAAAAGCCAAAACGGATTATAAACAAGCACAGTTAGATTTAGATATATCTAAGCAACA
TTTACAACTTCTTGAGCTTGAAAAAGCAGTAGAACAGGAAAAACTTAAAGAGCTAACGGAAAACAAAAAAGTAACGTTAA
GGAGCTTACAAAATACTAAACTTATTGCTATGGTACCCGGTATATTTGGTAATAGTAGTTTAGAAGTCGGAAATTACATA
GTACCGGGTAGGGTGTTGTTTTCTATAGTTCAAGATGATACTATGTACATTCAGGCTAATTTTAAAGAAACACAAATTAA
GAAATTTAAGTCCGGCATGAAAGTCAAAATTGAATTTGATGCTTTGCCTAAAAAAATAATTGACGGGAAAATTCGTAATA
TTGCTCCTGCTACCGGCTCTAAATTTAGTTTAATCCCACCCGATAATGCTACAGGTAATTTTACTAAAATCGTACAACGT
GTACCTGTTTTAATAGATTTTGAATCCCCAAATGCTAATCTAGTCCCTGGCATGTCAGCAATGGTATCAATCAGAACCGA
TCAAAAGACATAA

Upstream 100 bases:

>100_bases
TATATCCATGGTATTCACTGCCGTTAATTGCAGTTATATATATTCTTTCTATACCAATTTGTTATTTTTTTAAACATAGA
GGGTATTGGTGAAGTTAATT

Downstream 100 bases:

>100_bases
TTTTCGTCAAAAAATAGCAATAATTATTCTATTAAAAGTACATATTCTAGTATTATTTACTTATTACTTAAAAAGCTATA
GAATATCAGTAATACCAAAA

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MPSILQQAIDKYTRHPFTKYVTIIALIIFIYLGYRIYVWANTQSTDNAYIDADISNVSAEVSGVVTKLFVTDNTKVNKGD
LIAEIDDRDYKAKLAALEASIEACIKNIEIIEQKTSIGQIRLEQAAEKLKLTKISFDIVSTDFTRVQELNKAKFASSKTL
NDSKNAYQKAKTDYKQAQLDLDISKQHLQLLELEKAVEQEKLKELTENKKVTLRSLQNTKLIAMVPGIFGNSSLEVGNYI
VPGRVLFSIVQDDTMYIQANFKETQIKKFKSGMKVKIEFDALPKKIIDGKIRNIAPATGSKFSLIPPDNATGNFTKIVQR
VPVLIDFESPNANLVPGMSAMVSIRTDQKT

Sequences:

>Translated_350_residues
MPSILQQAIDKYTRHPFTKYVTIIALIIFIYLGYRIYVWANTQSTDNAYIDADISNVSAEVSGVVTKLFVTDNTKVNKGD
LIAEIDDRDYKAKLAALEASIEACIKNIEIIEQKTSIGQIRLEQAAEKLKLTKISFDIVSTDFTRVQELNKAKFASSKTL
NDSKNAYQKAKTDYKQAQLDLDISKQHLQLLELEKAVEQEKLKELTENKKVTLRSLQNTKLIAMVPGIFGNSSLEVGNYI
VPGRVLFSIVQDDTMYIQANFKETQIKKFKSGMKVKIEFDALPKKIIDGKIRNIAPATGSKFSLIPPDNATGNFTKIVQR
VPVLIDFESPNANLVPGMSAMVSIRTDQKT
>Mature_349_residues
PSILQQAIDKYTRHPFTKYVTIIALIIFIYLGYRIYVWANTQSTDNAYIDADISNVSAEVSGVVTKLFVTDNTKVNKGDL
IAEIDDRDYKAKLAALEASIEACIKNIEIIEQKTSIGQIRLEQAAEKLKLTKISFDIVSTDFTRVQELNKAKFASSKTLN
DSKNAYQKAKTDYKQAQLDLDISKQHLQLLELEKAVEQEKLKELTENKKVTLRSLQNTKLIAMVPGIFGNSSLEVGNYIV
PGRVLFSIVQDDTMYIQANFKETQIKKFKSGMKVKIEFDALPKKIIDGKIRNIAPATGSKFSLIPPDNATGNFTKIVQRV
PVLIDFESPNANLVPGMSAMVSIRTDQKT

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=336, Percent_Identity=28.8690476190476, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788711, Length=315, Percent_Identity=28.8888888888889, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790519, Length=319, Percent_Identity=26.3322884012539, Blast_Score=101, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39223; Mature: 39092

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSILQQAIDKYTRHPFTKYVTIIALIIFIYLGYRIYVWANTQSTDNAYIDADISNVSAE
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECHHHHHHH
VSGVVTKLFVTDNTKVNKGDLIAEIDDRDYKAKLAALEASIEACIKNIEIIEQKTSIGQI
HHHEEEEEEEECCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RLEQAAEKLKLTKISFDIVSTDFTRVQELNKAKFASSKTLNDSKNAYQKAKTDYKQAQLD
HHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
LDISKQHLQLLELEKAVEQEKLKELTENKKVTLRSLQNTKLIAMVPGIFGNSSLEVGNYI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEECCCEE
VPGRVLFSIVQDDTMYIQANFKETQIKKFKSGMKVKIEFDALPKKIIDGKIRNIAPATGS
CCHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCCHHHHCCCHHCCCCCCCC
KFSLIPPDNATGNFTKIVQRVPVLIDFESPNANLVPGMSAMVSIRTDQKT
EEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
PSILQQAIDKYTRHPFTKYVTIIALIIFIYLGYRIYVWANTQSTDNAYIDADISNVSAE
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECHHHHHHH
VSGVVTKLFVTDNTKVNKGDLIAEIDDRDYKAKLAALEASIEACIKNIEIIEQKTSIGQI
HHHEEEEEEEECCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
RLEQAAEKLKLTKISFDIVSTDFTRVQELNKAKFASSKTLNDSKNAYQKAKTDYKQAQLD
HHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
LDISKQHLQLLELEKAVEQEKLKELTENKKVTLRSLQNTKLIAMVPGIFGNSSLEVGNYI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCEECCCEE
VPGRVLFSIVQDDTMYIQANFKETQIKKFKSGMKVKIEFDALPKKIIDGKIRNIAPATGS
CCHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEEECCCCHHHHCCCHHCCCCCCCC
KFSLIPPDNATGNFTKIVQRVPVLIDFESPNANLVPGMSAMVSIRTDQKT
EEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]