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The map label for this gene is rnc

Identifier: 157825292

GI number: 157825292

Start: 163446

End: 164129

Strand: Direct

Name: rnc

Synonym: A1C_00870

Alternate gene names: 157825292

Gene position: 163446-164129 (Clockwise)

Preceding gene: 157825291

Following gene: 157825293

Centisome position: 13.28

GC content: 34.06

Gene sequence:

>684_bases
ATGCAATCATTTGAGACGTTAGAAAAGCTGCTTGGCTATAGTTTCAAAAATCAAGAGCTTTTAATAGAGGCGTTGAGTCA
CCCGTCTTTAAGACAACATCATGAGTATAAGTATGATAAAGATTATGAACGATTAGAGTTCCTAGGTGATGCTGTATTAA
ATTTAGTAGTCACCGAAATTTTATTTAGAAATTTTGCAAGTTATAATGAGGGGAATTTAGCTAAAATTAGATCATATTTA
GTTTGCAAAGAAACAATATGTGTGGTTGGGACCAAACTCACTTTAAAAGATTATATAATTATGACTTATGGTGAAGAAGT
AGCAGGAGGGCGTGATAATCCTAATAATATAGAAAATGCTATGGAAGCTTTGATTGCAGCTATATATCTTGATAGCAATA
TTGAAACAACCCGTAATATTATTGGGAAATTATGGGAAGAATTTATAAAAATTCAGAATTTAACGGATTATGACCCCAAA
ACTGCTTTACAAGAATGGGCTCAAGCGAGTAGCCATCACCTACCTATATACCGTCTGATAAAAAGAGAAGGAGCTGCCCA
TTCATCGACTTTTACGGTTCTTGTAAAAGTAAAAGATTATGAACAAACAGGTACAGGACACTCTATAAAAGAAGCCGAAA
AAAACGCAGCACGAGACTTATTGCACAGGCTTCAAGATGTATAA

Upstream 100 bases:

>100_bases
ATGATATAGGAGTTATGAATCTAGTACTAAGGTTAAAACCATGGATTGAATCTGTTAGGTTAAATCGAATTTTCAGAAAT
CTTTATAACACGGATGAGTA

Downstream 100 bases:

>100_bases
TCAGAGAACAATTTCAGTTTGTATCATTGGACGACCAAATAGCGGGAAGTCGACTTTGCTAAATAGAATAATCGGTGAGA
AACTTTCAATTGTTACGCCA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MQSFETLEKLLGYSFKNQELLIEALSHPSLRQHHEYKYDKDYERLEFLGDAVLNLVVTEILFRNFASYNEGNLAKIRSYL
VCKETICVVGTKLTLKDYIIMTYGEEVAGGRDNPNNIENAMEALIAAIYLDSNIETTRNIIGKLWEEFIKIQNLTDYDPK
TALQEWAQASSHHLPIYRLIKREGAAHSSTFTVLVKVKDYEQTGTGHSIKEAEKNAARDLLHRLQDV

Sequences:

>Translated_227_residues
MQSFETLEKLLGYSFKNQELLIEALSHPSLRQHHEYKYDKDYERLEFLGDAVLNLVVTEILFRNFASYNEGNLAKIRSYL
VCKETICVVGTKLTLKDYIIMTYGEEVAGGRDNPNNIENAMEALIAAIYLDSNIETTRNIIGKLWEEFIKIQNLTDYDPK
TALQEWAQASSHHLPIYRLIKREGAAHSSTFTVLVKVKDYEQTGTGHSIKEAEKNAARDLLHRLQDV
>Mature_227_residues
MQSFETLEKLLGYSFKNQELLIEALSHPSLRQHHEYKYDKDYERLEFLGDAVLNLVVTEILFRNFASYNEGNLAKIRSYL
VCKETICVVGTKLTLKDYIIMTYGEEVAGGRDNPNNIENAMEALIAAIYLDSNIETTRNIIGKLWEEFIKIQNLTDYDPK
TALQEWAQASSHHLPIYRLIKREGAAHSSTFTVLVKVKDYEQTGTGHSIKEAEKNAARDLLHRLQDV

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=191, Percent_Identity=31.413612565445, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI155030234, Length=191, Percent_Identity=31.413612565445, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1788920, Length=223, Percent_Identity=33.6322869955157, Blast_Score=117, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17506883, Length=207, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=204, Percent_Identity=30.3921568627451, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137682, Length=238, Percent_Identity=27.3109243697479, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026807, Length=94, Percent_Identity=36.1702127659575, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_RICAH (A8GM79)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493012.1
- ProteinModelPortal:   A8GM79
- SMR:   A8GM79
- STRING:   A8GM79
- GeneID:   5645325
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_00870
- NMPDR:   fig|293614.3.peg.162
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   RAKA293614:A1C_00870-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26058; Mature: 26058

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSFETLEKLLGYSFKNQELLIEALSHPSLRQHHEYKYDKDYERLEFLGDAVLNLVVTEI
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LFRNFASYNEGNLAKIRSYLVCKETICVVGTKLTLKDYIIMTYGEEVAGGRDNPNNIENA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEECHHHCCCCCCCHHHHHH
MEALIAAIYLDSNIETTRNIIGKLWEEFIKIQNLTDYDPKTALQEWAQASSHHLPIYRLI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
KREGAAHSSTFTVLVKVKDYEQTGTGHSIKEAEKNAARDLLHRLQDV
HHCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQSFETLEKLLGYSFKNQELLIEALSHPSLRQHHEYKYDKDYERLEFLGDAVLNLVVTEI
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LFRNFASYNEGNLAKIRSYLVCKETICVVGTKLTLKDYIIMTYGEEVAGGRDNPNNIENA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEECHHHCCCCCCCHHHHHH
MEALIAAIYLDSNIETTRNIIGKLWEEFIKIQNLTDYDPKTALQEWAQASSHHLPIYRLI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
KREGAAHSSTFTVLVKVKDYEQTGTGHSIKEAEKNAARDLLHRLQDV
HHCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA