Click here to switch to the map view.

The map label for this gene is era [H]

Identifier: 157825293

GI number: 157825293

Start: 164122

End: 165003

Strand: Direct

Name: era [H]

Synonym: A1C_00875

Alternate gene names: 157825293

Gene position: 164122-165003 (Clockwise)

Preceding gene: 157825292

Following gene: 157825294

Centisome position: 13.33

GC content: 33.22

Gene sequence:

>882_bases
ATGTATAATCAGAGAACAATTTCAGTTTGTATCATTGGACGACCAAATAGCGGGAAGTCGACTTTGCTAAATAGAATAAT
CGGTGAGAAACTTTCAATTGTTACGCCAAAAGTTCAAACGACTAGGTCAATTATTACCGGTATTATTACCTTAAAAGATA
CGCAGGTAATTTTATACGATACGCCAGGTATATTTGAGCCGAAAGGGAGCTTAGAGAAAGCAATGGTAAGATGTGCATGG
TCTAGTTTGCATAGTGCGGATTTAGTAATGTTAATTATCGATAGTTTAAAACCGTTTGATGATGTAACACACGATATTTT
AGATAAGCTTCGCTCACTTAATATTGTTCCGATATTTTTATTGAATAAAATAGATATCGAATCAAAATATCTAGATGACA
TTAAAGCTTTTTTAATAGGAAATCATCCTGATAGTTTGTTTTTTCCTATATCTGCTTTATCGGGCAAAAATATTAATGGA
TTACTTGAATATATAACAGGTAAGGCACAAATTGCTCCTTGGCTTTATGCAGAAGATGACATCACGGATTTACCGATGCG
TTTTATTGCGGCAGAAATCACAAGAGAGCAATTATTTTTTAATTTGCAGCAAGAGCTACCTTATAAATTAACCGTACAAA
CCGAAAAGTGGGAAGATCTTAAAGACAAATCCGTAAAGATTAATCAAGTTATAATAGTATCAAGAGCGAGTTATAAAACT
ATAATACTCGGTAAAAACGGATCGAAAATTAGAGAGATAGGGTCAAAATCTCGAATGCAAATGGAGCGGTTTTTTGGCTT
TCCTGTTCATTTATTTTTATTTGTTAAGGTGCATGAACTGTGGGAAAATCACCCAGATTTTTATCAGTATATGAAGATAT
GA

Upstream 100 bases:

>100_bases
GTTCTTGTAAAAGTAAAAGATTATGAACAAACAGGTACAGGACACTCTATAAAAGAAGCCGAAAAAAACGCAGCACGAGA
CTTATTGCACAGGCTTCAAG

Downstream 100 bases:

>100_bases
AGCTGTCACCCCGTGGCTTGACTACGGGGTCCAGTATTTTTATAATTATTTTATGGACCCCGTAGTCAAGCCACGGGGTG
ACACGGGATATATAATCATG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MYNQRTISVCIIGRPNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKAMVRCAW
SSLHSADLVMLIIDSLKPFDDVTHDILDKLRSLNIVPIFLLNKIDIESKYLDDIKAFLIGNHPDSLFFPISALSGKNING
LLEYITGKAQIAPWLYAEDDITDLPMRFIAAEITREQLFFNLQQELPYKLTVQTEKWEDLKDKSVKINQVIIVSRASYKT
IILGKNGSKIREIGSKSRMQMERFFGFPVHLFLFVKVHELWENHPDFYQYMKI

Sequences:

>Translated_293_residues
MYNQRTISVCIIGRPNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKAMVRCAW
SSLHSADLVMLIIDSLKPFDDVTHDILDKLRSLNIVPIFLLNKIDIESKYLDDIKAFLIGNHPDSLFFPISALSGKNING
LLEYITGKAQIAPWLYAEDDITDLPMRFIAAEITREQLFFNLQQELPYKLTVQTEKWEDLKDKSVKINQVIIVSRASYKT
IILGKNGSKIREIGSKSRMQMERFFGFPVHLFLFVKVHELWENHPDFYQYMKI
>Mature_293_residues
MYNQRTISVCIIGRPNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYDTPGIFEPKGSLEKAMVRCAW
SSLHSADLVMLIIDSLKPFDDVTHDILDKLRSLNIVPIFLLNKIDIESKYLDDIKAFLIGNHPDSLFFPISALSGKNING
LLEYITGKAQIAPWLYAEDDITDLPMRFIAAEITREQLFFNLQQELPYKLTVQTEKWEDLKDKSVKINQVIIVSRASYKT
IILGKNGSKIREIGSKSRMQMERFFGFPVHLFLFVKVHELWENHPDFYQYMKI

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RPE1 insert domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=327, Percent_Identity=30.2752293577982, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI1788919, Length=280, Percent_Identity=37.1428571428571, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI2367268, Length=89, Percent_Identity=34.8314606741573, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507259, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646434, Length=305, Percent_Identity=27.2131147540984, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005728
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33596; Mature: 33596

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNQRTISVCIIGRPNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYD
CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHEEEEEECCEEEEEC
TPGIFEPKGSLEKAMVRCAWSSLHSADLVMLIIDSLKPFDDVTHDILDKLRSLNIVPIFL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEE
LNKIDIESKYLDDIKAFLIGNHPDSLFFPISALSGKNINGLLEYITGKAQIAPWLYAEDD
EEECCCCHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCCEECCEEEECCC
ITDLPMRFIAAEITREQLFFNLQQELPYKLTVQTEKWEDLKDKSVKINQVIIVSRASYKT
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECCEEE
IILGKNGSKIREIGSKSRMQMERFFGFPVHLFLFVKVHELWENHPDFYQYMKI
EEEECCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MYNQRTISVCIIGRPNSGKSTLLNRIIGEKLSIVTPKVQTTRSIITGIITLKDTQVILYD
CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHEEEEEECCEEEEEC
TPGIFEPKGSLEKAMVRCAWSSLHSADLVMLIIDSLKPFDDVTHDILDKLRSLNIVPIFL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEE
LNKIDIESKYLDDIKAFLIGNHPDSLFFPISALSGKNINGLLEYITGKAQIAPWLYAEDD
EEECCCCHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCCEECCEEEECCC
ITDLPMRFIAAEITREQLFFNLQQELPYKLTVQTEKWEDLKDKSVKINQVIIVSRASYKT
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEEEEEECCEEE
IILGKNGSKIREIGSKSRMQMERFFGFPVHLFLFVKVHELWENHPDFYQYMKI
EEEECCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]