Definition Rickettsia akari str. Hartford, complete genome.
Accession NC_009881
Length 1,231,060

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The map label for this gene is lepB

Identifier: 157825291

GI number: 157825291

Start: 162646

End: 163446

Strand: Direct

Name: lepB

Synonym: A1C_00865

Alternate gene names: 157825291

Gene position: 162646-163446 (Clockwise)

Preceding gene: 157825290

Following gene: 157825292

Centisome position: 13.21

GC content: 31.46

Gene sequence:

>801_bases
ATGCAAACAGATAATACAAAATCCAACACTAATAAAACAGCTAAGCAAGAGTGGTGGTCTTGTGCTTTTGTAATATGTAT
CGCTTTACTTATTAGAATACTTATTATGGAGCCATTTACCGTTCCGACCGGTTCTATGAAAGCAACCATACTTGAGAATG
ACTATATCTTTTCTACGAAATATAGTTATGGTTATAGTAATTATTCTTTATCTTTTTTTGATTTTATTCCTCTTTTTAAA
GGGCGAATATTTGCTCGCGAACCGGAGCGTGGCGATATTGTAGTTTTTCGTCCGCCTAACGATATGAATGTTAGATATAT
AAAGCGTTTAATAGGGCTACCAGGCGATAAAATTCAATTGATTGATGATGTAATATATATTAACGATAAAAAAATAGAAC
GCACTGAAGTTGGAACTTATACAAGCGAAGATGGAATAAAATATTTGAAGTTTAAAGAAACCTTGCCAAACGGTAGAACA
TATTTTTCTTATAAGCTTGCTCCTATTTTTAGCGTTATATATAACGATAGATACGGTAACACGGATGTTTTTTATGTACC
TGAAGGGAAATATTTCTTTTTAGGGGATAATAGAGATCAGTCAAATGATAGTAGAGTAAATCTTGGATTTGTACCATTTG
AAAATTTTATTGCTAAAGCACAATTTATTTGGTTCTCAACAAAAATAAATTGGTGGGATAATGATATAGGAGTTATGAAT
CTAGTACTAAGGTTAAAACCATGGATTGAATCTGTTAGGTTAAATCGAATTTTCAGAAATCTTTATAACACGGATGAGTA
A

Upstream 100 bases:

>100_bases
CGTCAATTACTTTGTAATGTCCTCGCAATGACGGAAGCCATACAACAAGGCTTACAGTCGTTCACAATGACGATTGCAAT
TTAAAAATAATTAAGAGATT

Downstream 100 bases:

>100_bases
TGCAATCATTTGAGACGTTAGAAAAGCTGCTTGGCTATAGTTTCAAAAATCAAGAGCTTTTAATAGAGGCGTTGAGTCAC
CCGTCTTTAAGACAACATCA

Product: Signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MQTDNTKSNTNKTAKQEWWSCAFVICIALLIRILIMEPFTVPTGSMKATILENDYIFSTKYSYGYSNYSLSFFDFIPLFK
GRIFAREPERGDIVVFRPPNDMNVRYIKRLIGLPGDKIQLIDDVIYINDKKIERTEVGTYTSEDGIKYLKFKETLPNGRT
YFSYKLAPIFSVIYNDRYGNTDVFYVPEGKYFFLGDNRDQSNDSRVNLGFVPFENFIAKAQFIWFSTKINWWDNDIGVMN
LVLRLKPWIESVRLNRIFRNLYNTDE

Sequences:

>Translated_266_residues
MQTDNTKSNTNKTAKQEWWSCAFVICIALLIRILIMEPFTVPTGSMKATILENDYIFSTKYSYGYSNYSLSFFDFIPLFK
GRIFAREPERGDIVVFRPPNDMNVRYIKRLIGLPGDKIQLIDDVIYINDKKIERTEVGTYTSEDGIKYLKFKETLPNGRT
YFSYKLAPIFSVIYNDRYGNTDVFYVPEGKYFFLGDNRDQSNDSRVNLGFVPFENFIAKAQFIWFSTKINWWDNDIGVMN
LVLRLKPWIESVRLNRIFRNLYNTDE
>Mature_266_residues
MQTDNTKSNTNKTAKQEWWSCAFVICIALLIRILIMEPFTVPTGSMKATILENDYIFSTKYSYGYSNYSLSFFDFIPLFK
GRIFAREPERGDIVVFRPPNDMNVRYIKRLIGLPGDKIQLIDDVIYINDKKIERTEVGTYTSEDGIKYLKFKETLPNGRT
YFSYKLAPIFSVIYNDRYGNTDVFYVPEGKYFFLGDNRDQSNDSRVNLGFVPFENFIAKAQFIWFSTKINWWDNDIGVMN
LVLRLKPWIESVRLNRIFRNLYNTDE

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family

Homologues:

Organism=Escherichia coli, GI1788921, Length=299, Percent_Identity=31.1036789297659, Blast_Score=114, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEP_RICAH (A8GM78)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493011.1
- ProteinModelPortal:   A8GM78
- SMR:   A8GM78
- STRING:   A8GM78
- GeneID:   5645095
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_00865
- NMPDR:   fig|293614.3.peg.161
- eggNOG:   COG0681
- HOGENOM:   HBG596607
- OMA:   KPWIESV
- ProtClustDB:   CLSK870751
- BioCyc:   RAKA293614:A1C_00865-MONOMER
- GO:   GO:0006508
- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- Gene3D:   G3DSA:2.10.109.10
- PRINTS:   PR00727
- TIGRFAMs:   TIGR02227

Pfam domain/function: PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.89

Molecular weight: Translated: 31328; Mature: 31328

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00760 SPASE_I_2; PS00761 SPASE_I_3

Important sites: ACT_SITE 45-45 ACT_SITE 108-108

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MQTDNTKSNTNKTAKQEWWSCAFVICIALLIRILIMEPFTVPTGSMKATILENDYIFSTK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEE
YSYGYSNYSLSFFDFIPLFKGRIFAREPERGDIVVFRPPNDMNVRYIKRLIGLPGDKIQL
ECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEE
IDDVIYINDKKIERTEVGTYTSEDGIKYLKFKETLPNGRTYFSYKLAPIFSVIYNDRYGN
EEEEEEECCCEEEEEECCCEECCCCEEEEEEECCCCCCCEEEEEEHHHHHHHHHCCCCCC
TDVFYVPEGKYFFLGDNRDQSNDSRVNLGFVPFENFIAKAQFIWFSTKINWWDNDIGVMN
CEEEEEECCCEEEEECCCCCCCCCEEEEEEECHHHHHHEEEEEEEEEEEEEECCCHHHHH
LVLRLKPWIESVRLNRIFRNLYNTDE
HHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MQTDNTKSNTNKTAKQEWWSCAFVICIALLIRILIMEPFTVPTGSMKATILENDYIFSTK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEE
YSYGYSNYSLSFFDFIPLFKGRIFAREPERGDIVVFRPPNDMNVRYIKRLIGLPGDKIQL
ECCCCCCCCCHHHHHHHHHCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEE
IDDVIYINDKKIERTEVGTYTSEDGIKYLKFKETLPNGRTYFSYKLAPIFSVIYNDRYGN
EEEEEEECCCEEEEEECCCEECCCCEEEEEEECCCCCCCEEEEEEHHHHHHHHHCCCCCC
TDVFYVPEGKYFFLGDNRDQSNDSRVNLGFVPFENFIAKAQFIWFSTKINWWDNDIGVMN
CEEEEEECCCEEEEECCCCCCCCCEEEEEEECHHHHHHEEEEEEEEEEEEEECCCHHHHH
LVLRLKPWIESVRLNRIFRNLYNTDE
HHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA