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The map label for this gene is nuoF

Identifier: 157825290

GI number: 157825290

Start: 161250

End: 162521

Strand: Direct

Name: nuoF

Synonym: A1C_00860

Alternate gene names: 157825290

Gene position: 161250-162521 (Clockwise)

Preceding gene: 157825289

Following gene: 157825291

Centisome position: 13.1

GC content: 41.27

Gene sequence:

>1272_bases
ATGCTAAAAGAAGAAGACAAAATTTTTACTAACCTACATGGGGGGCAAATCCATGATTTGAAATCTAGCAAGAAGCGAGG
CGATTGGGATAATACTAAAGCTTTACTTGATAAAGGTAGAGACTTTATCATTGAAGAGATCAAGAAATCAGGGCTTAGAG
GGCGGGGCGGTGCCGGATTTTCTACCGGTATGAAATGGTCGTTTATGCCCAAAAATTCAGAGAAGCCTTGCTATTTAGTA
GTAAATGCCGACGAGTCTGAGCCTGGTACTTGTAAGGATCGTGATATATTAAGGTTTGAGCCGCACAAATTAATAGAAGG
TTGCTTGCTTGCAAGCTTTGCTATAGGAGCGAATAATTGCTATATCTATATTAGAGGTGAGTTTTATAATGAAGCTTCTA
ATATTCAGCGTGCCTTAGATGAGGCTTATAAAGACAGGTTAATAGGAAAGAATGCTTGCGGTTCAGGGTTTGATTGTAAT
ATTTATTTACACCGTGGGGCAGGGGCTTATATTTGCGGTGAGGAAACGGCATTACTTGAAAGCTTAGAGGGTAAAAAAGG
CATGCCTCGTTTAAAGCCGCCTTTTCCTGCCGGATTTGGTCTATATGGCTGCCCGACTACTATAAATAATGTTGAGTCTA
TCGCAGTAGTGCCGACCATTTTAAGACGAAGAGCTAGTTGGTTTGCTTCTATCGGTAAGCCTAACAATACCGGTACTAAG
ATTTTCTGCATATCTGGGCATGTTAATAAGCCTTGCAATGTTGAAGAGGCAATGGGAATTTCGTTAAAAGAATTGATTGA
GAAATATGCAGGTGGTGTTCGAGGCGGTTGGGATAATCTTAAAGCCATAATTCCAGGCGGTTCTTCCGTGCCTTTACTTC
CTAAGTCATTATGTGAAGTGGATATGGATTTTGATAGTTTAAGAACCGTAGGTTCCGGCCTTGGTACAGGTGGTATTATA
GTTATGGATAAATCTACCGACATTATTTATGCAATAGCACGCCTTAGTAAATTTTACATGCATGAATCATGCGGGCAATG
TACTCCTTGCCGTGAAGGTACGGGCTGGATGTGGCGAGTTATGATACGTCTAGTTAAAGGTAATGCCAAAAAATCCGAGA
TCGACGAACTTCTTAATGTTACGAAAGAAATAGAGGGGCATACTATTTGTGCCTTAGGTGATGCGGCAGCTTGGCCAATC
CAAGGGCTGATACGCCATTTTAGAAGCGAGATTGAGGATAGGATAAAGAGTTATAGCGTGGCAATCTCATGA

Upstream 100 bases:

>100_bases
CTGGATTGCCACTAAGCCTATGGCTGCTCGCAATGATAATTTTCGAACCACGCTTGTCTTGCCTCACAATGACGTTTTTA
AGCCATAACGAGAATAGTTT

Downstream 100 bases:

>100_bases
AGTAATAAACTCCTGAGATTGCTTCGTCAATTACTTTGTAATGTCCTCGCAATGACGGAAGCCATACAACAAGGCTTACA
GTCGTTCACAATGACGATTG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLKEEDKIFTNLHGGQIHDLKSSKKRGDWDNTKALLDKGRDFIIEEIKKSGLRGRGGAGFSTGMKWSFMPKNSEKPCYLV
VNADESEPGTCKDRDILRFEPHKLIEGCLLASFAIGANNCYIYIRGEFYNEASNIQRALDEAYKDRLIGKNACGSGFDCN
IYLHRGAGAYICGEETALLESLEGKKGMPRLKPPFPAGFGLYGCPTTINNVESIAVVPTILRRRASWFASIGKPNNTGTK
IFCISGHVNKPCNVEEAMGISLKELIEKYAGGVRGGWDNLKAIIPGGSSVPLLPKSLCEVDMDFDSLRTVGSGLGTGGII
VMDKSTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRVMIRLVKGNAKKSEIDELLNVTKEIEGHTICALGDAAAWPI
QGLIRHFRSEIEDRIKSYSVAIS

Sequences:

>Translated_423_residues
MLKEEDKIFTNLHGGQIHDLKSSKKRGDWDNTKALLDKGRDFIIEEIKKSGLRGRGGAGFSTGMKWSFMPKNSEKPCYLV
VNADESEPGTCKDRDILRFEPHKLIEGCLLASFAIGANNCYIYIRGEFYNEASNIQRALDEAYKDRLIGKNACGSGFDCN
IYLHRGAGAYICGEETALLESLEGKKGMPRLKPPFPAGFGLYGCPTTINNVESIAVVPTILRRRASWFASIGKPNNTGTK
IFCISGHVNKPCNVEEAMGISLKELIEKYAGGVRGGWDNLKAIIPGGSSVPLLPKSLCEVDMDFDSLRTVGSGLGTGGII
VMDKSTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRVMIRLVKGNAKKSEIDELLNVTKEIEGHTICALGDAAAWPI
QGLIRHFRSEIEDRIKSYSVAIS
>Mature_423_residues
MLKEEDKIFTNLHGGQIHDLKSSKKRGDWDNTKALLDKGRDFIIEEIKKSGLRGRGGAGFSTGMKWSFMPKNSEKPCYLV
VNADESEPGTCKDRDILRFEPHKLIEGCLLASFAIGANNCYIYIRGEFYNEASNIQRALDEAYKDRLIGKNACGSGFDCN
IYLHRGAGAYICGEETALLESLEGKKGMPRLKPPFPAGFGLYGCPTTINNVESIAVVPTILRRRASWFASIGKPNNTGTK
IFCISGHVNKPCNVEEAMGISLKELIEKYAGGVRGGWDNLKAIIPGGSSVPLLPKSLCEVDMDFDSLRTVGSGLGTGGII
VMDKSTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRVMIRLVKGNAKKSEIDELLNVTKEIEGHTICALGDAAAWPI
QGLIRHFRSEIEDRIKSYSVAIS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=67.3031026252983, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=67.3031026252983, Blast_Score=592, Evalue=1e-169,
Organism=Escherichia coli, GI1788620, Length=387, Percent_Identity=43.6692506459948, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=419, Percent_Identity=64.200477326969, Blast_Score=569, Evalue=1e-163,
Organism=Drosophila melanogaster, GI19920794, Length=424, Percent_Identity=66.0377358490566, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI45550452, Length=417, Percent_Identity=63.3093525179856, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24653819, Length=422, Percent_Identity=47.8672985781991, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24653817, Length=422, Percent_Identity=44.5497630331754, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOF_RICAH (A8GM77)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493010.1
- ProteinModelPortal:   A8GM77
- SMR:   A8GM77
- STRING:   A8GM77
- GeneID:   5645094
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_00860
- NMPDR:   fig|293614.3.peg.160
- eggNOG:   COG1894
- HOGENOM:   HBG669338
- OMA:   HFYMHES
- ProtClustDB:   PRK13596
- BioCyc:   RAKA293614:A1C_00860-MONOMER
- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554
- SMART:   SM00928
- TIGRFAMs:   TIGR01959

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB

EC number: =1.6.99.5

Molecular weight: Translated: 46537; Mature: 46537

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00644 COMPLEX1_51K_1; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEEDKIFTNLHGGQIHDLKSSKKRGDWDNTKALLDKGRDFIIEEIKKSGLRGRGGAGF
CCCCCCCHHHCCCCCEEECCHHHCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
STGMKWSFMPKNSEKPCYLVVNADESEPGTCKDRDILRFEPHKLIEGCLLASFAIGANNC
CCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCE
YIYIRGEFYNEASNIQRALDEAYKDRLIGKNACGSGFDCNIYLHRGAGAYICGEETALLE
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPAGFGLYGCPTTINNVESIAVVPTILRRRASWFASIGKPNNTGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IFCISGHVNKPCNVEEAMGISLKELIEKYAGGVRGGWDNLKAIIPGGSSVPLLPKSLCEV
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHC
DMDFDSLRTVGSGLGTGGIIVMDKSTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRV
CCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
MIRLVKGNAKKSEIDELLNVTKEIEGHTICALGDAAAWPIQGLIRHFRSEIEDRIKSYSV
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCE
AIS
ECC
>Mature Secondary Structure
MLKEEDKIFTNLHGGQIHDLKSSKKRGDWDNTKALLDKGRDFIIEEIKKSGLRGRGGAGF
CCCCCCCHHHCCCCCEEECCHHHCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
STGMKWSFMPKNSEKPCYLVVNADESEPGTCKDRDILRFEPHKLIEGCLLASFAIGANNC
CCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCE
YIYIRGEFYNEASNIQRALDEAYKDRLIGKNACGSGFDCNIYLHRGAGAYICGEETALLE
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRLKPPFPAGFGLYGCPTTINNVESIAVVPTILRRRASWFASIGKPNNTGTK
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IFCISGHVNKPCNVEEAMGISLKELIEKYAGGVRGGWDNLKAIIPGGSSVPLLPKSLCEV
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHC
DMDFDSLRTVGSGLGTGGIIVMDKSTDIIYAIARLSKFYMHESCGQCTPCREGTGWMWRV
CCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
MIRLVKGNAKKSEIDELLNVTKEIEGHTICALGDAAAWPIQGLIRHFRSEIEDRIKSYSV
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCE
AIS
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA