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The map label for this gene is tlcA [H]

Identifier: 157825209

GI number: 157825209

Start: 69227

End: 70723

Strand: Direct

Name: tlcA [H]

Synonym: A1C_00440

Alternate gene names: 157825209

Gene position: 69227-70723 (Clockwise)

Preceding gene: 157825207

Following gene: 157825210

Centisome position: 5.62

GC content: 32.26

Gene sequence:

>1497_bases
ATGAGTACTCCTAAAAGTGACAATTGTCTCTCGGAACTAAGAAAGGTAATTTGGCCTATAGAACGATATGAAAATAAGAA
GTTTCTTCCTATGGCGTTTATGATGTTCTGTATTTTATTAAACTACTCAACGCTTCGTTCAATTAAAGATGGGTTTGTAG
TAACGGATATAGGGGCGGAAGCAATAAGTTTCTTAAAAACATATATAGTACTACCTTCTGCCGTAGTCGCTATGGTAATT
TATGTTAAGCTCTGCGATATTTTAAAGCAAGAAAACGTATTTTATGTTATTGCTTCATTTTTCTTAGGGTATTTTGCGTT
ATTTGCTTTTGTGCTTTACCCTTATCCTGATTTAGTTCATCCTGATCCTGAAACCATAGAATCTTTAAGTTTAGCTTACC
CTAATTTTAAATGGTTTATAAGAATAGTTGGTCAATGGAGTTTTGCATCTTTTTATACTATGGCAGAGCTTTGGGGAACA
ATGATGCTTAGTTTATTATTTTGGCAGTTTGCTAACCAAATTACCAAAACCGATGAAGCTAAACGTTTTTACTCAATGTT
TGGTTTACTTGCTAATTTAGCATTGCCTGTAACATCAGTGATTATTGGATATTTCTTGCATGAAAAGACTCAAATAGTTG
CAGAACATCTAAAATTTGTGCCTTTATTTGTTATAATGATGACAAGTAGCTTGTTGGTAATATTAACATATAGATGGATG
AATAAAAATGTTCTAACCGATCCTGGACTTTATGATCCGGCATTAGTAAAAGAAAAGAAAGCTAAAGCTAAAATGTCATT
AATAGACAGTTTTAAAATGATCTTCACCTCTAAGTATGTAGGTTATATTGCGTTGTTACTTATTGCTTACGGTGTTTCAG
TAAATTTAGTTGAAGGTGTTTGGAAATCCAAAGTAAAAGAATTGTATCCGACGAAAGAGGCGTATACTATATATATGGGT
AAGTTCCAATTTTATCAAGGTTGGGTTGCAATTGCTTTCATGCTTATAGGTAGTAATATTTTAAGAAAAGTATCATGGCT
AACTGCAGCTATGATAACTCCATTAATGATGTTAATTACCGGTGCAGCATTTTTTACATTTATCTTTTTTGATAGTGTTA
TTGCTATGCATTTAACAGGTATTCTTGCTTCAGGTCCTTTAGCACTTGCTGTTATGATTGGTATGATTCAAAATGTTTTA
AGTAAAGGTGTAAAATATTCCTTATTTGATGCCACTAAAAACATGGCATATATCCCGCTTGATAAGGATTTACGAGTAAA
AGGGCAAGCTGCTGTTGAAGTTATCGGAGGAAGATTCGGTAAATCAGGCGGTGCTATTATTCAATCTACATTCTTTATTT
TATTTCCTGCATTTGGTTTTGTAGAGGCGACTCCTTATTTTGCTTCTATATTCTTTGTAATAGTAATATTATGGATATAT
GCTGTTAAAGGTTTAAATAAAGAGTATCAAGTTTTGGTAAATAAAACTGAAAAATAG

Upstream 100 bases:

>100_bases
TTTTATTTAATTTACTTTGAGAAAAAATCAATAAGGTTTGACTTCTCTAACATATTCTAGTATAGTGCTTATTTTCAAAA
TAAATAGAAAAATTTAATTT

Downstream 100 bases:

>100_bases
AATGTGTTAAAATTTAATATTATAACAAAAGTAAGCTGCTCGACTCTGAAACTTGCTTTTTTTATAGTCGTGGAGTTTAT
AATATGACAGATACAAAACC

Product: ADP,ATP carrier protein

Products: NA

Alternate protein names: ADP/ATP translocase 1 [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSTPKSDNCLSELRKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAEAISFLKTYIVLPSAVVAMVI
YVKLCDILKQENVFYVIASFFLGYFALFAFVLYPYPDLVHPDPETIESLSLAYPNFKWFIRIVGQWSFASFYTMAELWGT
MMLSLLFWQFANQITKTDEAKRFYSMFGLLANLALPVTSVIIGYFLHEKTQIVAEHLKFVPLFVIMMTSSLLVILTYRWM
NKNVLTDPGLYDPALVKEKKAKAKMSLIDSFKMIFTSKYVGYIALLLIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMG
KFQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMLITGAAFFTFIFFDSVIAMHLTGILASGPLALAVMIGMIQNVL
SKGVKYSLFDATKNMAYIPLDKDLRVKGQAAVEVIGGRFGKSGGAIIQSTFFILFPAFGFVEATPYFASIFFVIVILWIY
AVKGLNKEYQVLVNKTEK

Sequences:

>Translated_498_residues
MSTPKSDNCLSELRKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAEAISFLKTYIVLPSAVVAMVI
YVKLCDILKQENVFYVIASFFLGYFALFAFVLYPYPDLVHPDPETIESLSLAYPNFKWFIRIVGQWSFASFYTMAELWGT
MMLSLLFWQFANQITKTDEAKRFYSMFGLLANLALPVTSVIIGYFLHEKTQIVAEHLKFVPLFVIMMTSSLLVILTYRWM
NKNVLTDPGLYDPALVKEKKAKAKMSLIDSFKMIFTSKYVGYIALLLIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMG
KFQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMLITGAAFFTFIFFDSVIAMHLTGILASGPLALAVMIGMIQNVL
SKGVKYSLFDATKNMAYIPLDKDLRVKGQAAVEVIGGRFGKSGGAIIQSTFFILFPAFGFVEATPYFASIFFVIVILWIY
AVKGLNKEYQVLVNKTEK
>Mature_497_residues
STPKSDNCLSELRKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAEAISFLKTYIVLPSAVVAMVIY
VKLCDILKQENVFYVIASFFLGYFALFAFVLYPYPDLVHPDPETIESLSLAYPNFKWFIRIVGQWSFASFYTMAELWGTM
MLSLLFWQFANQITKTDEAKRFYSMFGLLANLALPVTSVIIGYFLHEKTQIVAEHLKFVPLFVIMMTSSLLVILTYRWMN
KNVLTDPGLYDPALVKEKKAKAKMSLIDSFKMIFTSKYVGYIALLLIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMGK
FQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMLITGAAFFTFIFFDSVIAMHLTGILASGPLALAVMIGMIQNVLS
KGVKYSLFDATKNMAYIPLDKDLRVKGQAAVEVIGGRFGKSGGAIIQSTFFILFPAFGFVEATPYFASIFFVIVILWIYA
VKGLNKEYQVLVNKTEK

Specific function: Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism [H]

COG id: COG3202

COG function: function code C; ATP/ADP translocase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ADP/ATP translocase tlc family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004667 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 56508; Mature: 56377

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCHHHHHHHCCCCC
>Mature Secondary Structure 
STPKSDNCLSELRKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAE
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHH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HHHCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2555259; 9823893; 1904433; 2165754; 9917392 [H]